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Article: Anchored but not internalized: Shape dependent endocytosis of nanodiamond

TitleAnchored but not internalized: Shape dependent endocytosis of nanodiamond
Authors
Issue Date2017
Citation
Scientific Reports, 2017, v. 7, article no. 46462 (2017) How to Cite?
Abstract© 2017 The Author(s). Nanoparticle-cell interactions begin with the cellular uptake of the nanoparticles, a process that eventually determines their cellular fate. In the present work, we show that the morphological features of nanodiamonds (NDs) affect both the anchoring and internalization stages of their endocytosis. While a prickly ND (with sharp edges/corners) has no trouble of anchoring onto the plasma membrane, it suffers from difficult internalization afterwards. In comparison, the internalization of a round ND (obtained by selective etching of the prickly ND) is not limited by its lower anchoring amount and presents a much higher endocytosis amount. Molecular dynamics simulation and continuum modelling results suggest that the observed difference in the anchoring of round and prickly NDs likely results from the reduced contact surface area with the cell membrane of the former, while the energy penalty associated with membrane curvature generation, which is lower for a round ND, may explain its higher probability of the subsequent internalization.
Persistent Identifierhttp://hdl.handle.net/10722/265701
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorZhang, Bokai-
dc.contributor.authorFeng, Xi-
dc.contributor.authorYin, Hang-
dc.contributor.authorGe, Zhenpeng-
dc.contributor.authorWang, Yanhuan-
dc.contributor.authorChu, Zhiqin-
dc.contributor.authorRaabova, Helena-
dc.contributor.authorVavra, Jan-
dc.contributor.authorCigler, Petr-
dc.contributor.authorLiu, Renbao-
dc.contributor.authorWang, Yi-
dc.contributor.authorLi, Quan-
dc.date.accessioned2018-12-03T01:21:26Z-
dc.date.available2018-12-03T01:21:26Z-
dc.date.issued2017-
dc.identifier.citationScientific Reports, 2017, v. 7, article no. 46462 (2017)-
dc.identifier.urihttp://hdl.handle.net/10722/265701-
dc.description.abstract© 2017 The Author(s). Nanoparticle-cell interactions begin with the cellular uptake of the nanoparticles, a process that eventually determines their cellular fate. In the present work, we show that the morphological features of nanodiamonds (NDs) affect both the anchoring and internalization stages of their endocytosis. While a prickly ND (with sharp edges/corners) has no trouble of anchoring onto the plasma membrane, it suffers from difficult internalization afterwards. In comparison, the internalization of a round ND (obtained by selective etching of the prickly ND) is not limited by its lower anchoring amount and presents a much higher endocytosis amount. Molecular dynamics simulation and continuum modelling results suggest that the observed difference in the anchoring of round and prickly NDs likely results from the reduced contact surface area with the cell membrane of the former, while the energy penalty associated with membrane curvature generation, which is lower for a round ND, may explain its higher probability of the subsequent internalization.-
dc.languageeng-
dc.relation.ispartofScientific Reports-
dc.rightsThis work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.-
dc.titleAnchored but not internalized: Shape dependent endocytosis of nanodiamond-
dc.typeArticle-
dc.description.naturepublished_or_final_version-
dc.identifier.doi10.1038/srep46462-
dc.identifier.scopuseid_2-s2.0-85017420978-
dc.identifier.volume7-
dc.identifier.spagearticle no. 46462 (2017)-
dc.identifier.epagearticle no. 46462 (2017)-
dc.identifier.eissn2045-2322-
dc.identifier.isiWOS:000399030800001-
dc.identifier.issnl2045-2322-

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