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Article: Shape dependent cytotoxicity of PLGA-PEG nanoparticles on human cells

TitleShape dependent cytotoxicity of PLGA-PEG nanoparticles on human cells
Authors
Issue Date2017
Citation
Scientific Reports, 2017, v. 7, n. 1, article no. 7315 (2017) How to Cite?
Abstract© 2017 The Author(s). We investigated the influence of nanoparticles' shape on the physiological responses of cells, when they were fed with spherical and needle-shaped PLGA-PEG nanoparticles (the volume of the nanoparticles had been chosen as the fixed parameter). We found that both types of NPs entered cells via endocytosis and upon internalization they stayed in membrane bounded vesicles. Needle-shaped, but not the spherical-shaped NPs were found to induce significant cytotoxicity in the cell lines tested. Our study evidenced that the cytotoxicity of needle-shaped NPs was induced through the lysosome disruption. Lysosome damage activated the signaling pathways for cell apoptosis, and eventually caused DNA fragmentation and cell death. The present work showed that physiological response of the cells can be very different when the shape of the fed nanoparticles changed from spherical to needle-like. The finding suggests that the toxicity of nanomaterials also depends on their shape.
Persistent Identifierhttp://hdl.handle.net/10722/265713
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorZhang, Bokai-
dc.contributor.authorSai Lung, Ping-
dc.contributor.authorZhao, Saisai-
dc.contributor.authorChu, Zhiqin-
dc.contributor.authorChrzanowski, Wojciech-
dc.contributor.authorLi, Quan-
dc.date.accessioned2018-12-03T01:21:28Z-
dc.date.available2018-12-03T01:21:28Z-
dc.date.issued2017-
dc.identifier.citationScientific Reports, 2017, v. 7, n. 1, article no. 7315 (2017)-
dc.identifier.urihttp://hdl.handle.net/10722/265713-
dc.description.abstract© 2017 The Author(s). We investigated the influence of nanoparticles' shape on the physiological responses of cells, when they were fed with spherical and needle-shaped PLGA-PEG nanoparticles (the volume of the nanoparticles had been chosen as the fixed parameter). We found that both types of NPs entered cells via endocytosis and upon internalization they stayed in membrane bounded vesicles. Needle-shaped, but not the spherical-shaped NPs were found to induce significant cytotoxicity in the cell lines tested. Our study evidenced that the cytotoxicity of needle-shaped NPs was induced through the lysosome disruption. Lysosome damage activated the signaling pathways for cell apoptosis, and eventually caused DNA fragmentation and cell death. The present work showed that physiological response of the cells can be very different when the shape of the fed nanoparticles changed from spherical to needle-like. The finding suggests that the toxicity of nanomaterials also depends on their shape.-
dc.languageeng-
dc.relation.ispartofScientific Reports-
dc.rightsThis work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.-
dc.titleShape dependent cytotoxicity of PLGA-PEG nanoparticles on human cells-
dc.typeArticle-
dc.description.naturepublished_or_final_version-
dc.identifier.doi10.1038/s41598-017-07588-9-
dc.identifier.scopuseid_2-s2.0-85026839854-
dc.identifier.volume7-
dc.identifier.issue1-
dc.identifier.spagearticle no. 7315 (2017)-
dc.identifier.epagearticle no. 7315 (2017)-
dc.identifier.eissn2045-2322-
dc.identifier.isiWOS:000406980800054-
dc.identifier.issnl2045-2322-

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