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Article: Co-existing malignant lesions in atypical ductal hyperplasia – Pathology, probability, predictors and prognosis
Title | Co-existing malignant lesions in atypical ductal hyperplasia – Pathology, probability, predictors and prognosis |
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Authors | |
Keywords | Breast neoplasms Carcinoma Intraductal Noninfiltrating Risk factors |
Issue Date | 2020 |
Publisher | Elsevier: Creative Commons Attribution Non-Commercial No-Derivatives License. The Journal's web site is located at http://www.elsevier.com/wps/find/journaldescription.cws_home/708511/description#description |
Citation | Asian Journal of Surgery, 2020, v. 43, p. 240-243 How to Cite? |
Abstract | BACKGROUND: Atypical ductal hyperplasia (ADH) is known to be associated with underlying malignant breast conditions. Previous studies have shown that up to 40% of ADH found in core needle biopsy of the breasts had undiagnosed malignant lesions after excision. METHODS: This is a retrospective study on a prospectively maintained database. From 1st January 2005 to 31st December 2014, a total of 262 excision or mastectomy specimens were identified to contain ADH. Clinical, radiological and pathological data were retrieved and analyzed. Correlating factors for the presence of co-existing pre-malignant or malignant conditions were analyzed. Overall survival in patients with or without co-existing malignant breast lesions were evaluated. RESULTS: 95 (36.3%) had co-existing malignant breast lesions within the same specimen. The median age at diagnosis was 49 (Range 17-85). Suspicious breast imaging features (BIRADS 4 or above) and lesions larger than 10 mm on breast imaging were independent risk factor for co-existing malignant pathology (p < 0.001 and 0.005 respectively). After median follow-up interval of 60 months (6-120 months), the overall survival was comparable between the groups of patients having ADH with or without co-existing malignant pathologies (98.2% and 97.9% respectively). CONCLUSION: Co-existing malignant lesions were present in up to 36.3% of the pathology specimens containing ADH, in which its presence could be predicted by pre-operative breast imaging. |
Persistent Identifier | http://hdl.handle.net/10722/271311 |
ISSN | 2023 Impact Factor: 3.5 2023 SCImago Journal Rankings: 0.538 |
ISI Accession Number ID |
DC Field | Value | Language |
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dc.contributor.author | Co, M | - |
dc.contributor.author | Shek, T | - |
dc.contributor.author | Kwong, A | - |
dc.date.accessioned | 2019-06-24T01:07:25Z | - |
dc.date.available | 2019-06-24T01:07:25Z | - |
dc.date.issued | 2020 | - |
dc.identifier.citation | Asian Journal of Surgery, 2020, v. 43, p. 240-243 | - |
dc.identifier.issn | 1015-9584 | - |
dc.identifier.uri | http://hdl.handle.net/10722/271311 | - |
dc.description.abstract | BACKGROUND: Atypical ductal hyperplasia (ADH) is known to be associated with underlying malignant breast conditions. Previous studies have shown that up to 40% of ADH found in core needle biopsy of the breasts had undiagnosed malignant lesions after excision. METHODS: This is a retrospective study on a prospectively maintained database. From 1st January 2005 to 31st December 2014, a total of 262 excision or mastectomy specimens were identified to contain ADH. Clinical, radiological and pathological data were retrieved and analyzed. Correlating factors for the presence of co-existing pre-malignant or malignant conditions were analyzed. Overall survival in patients with or without co-existing malignant breast lesions were evaluated. RESULTS: 95 (36.3%) had co-existing malignant breast lesions within the same specimen. The median age at diagnosis was 49 (Range 17-85). Suspicious breast imaging features (BIRADS 4 or above) and lesions larger than 10 mm on breast imaging were independent risk factor for co-existing malignant pathology (p < 0.001 and 0.005 respectively). After median follow-up interval of 60 months (6-120 months), the overall survival was comparable between the groups of patients having ADH with or without co-existing malignant pathologies (98.2% and 97.9% respectively). CONCLUSION: Co-existing malignant lesions were present in up to 36.3% of the pathology specimens containing ADH, in which its presence could be predicted by pre-operative breast imaging. | - |
dc.language | eng | - |
dc.publisher | Elsevier: Creative Commons Attribution Non-Commercial No-Derivatives License. The Journal's web site is located at http://www.elsevier.com/wps/find/journaldescription.cws_home/708511/description#description | - |
dc.relation.ispartof | Asian Journal of Surgery | - |
dc.rights | This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License. | - |
dc.subject | Breast neoplasms | - |
dc.subject | Carcinoma | - |
dc.subject | Intraductal | - |
dc.subject | Noninfiltrating | - |
dc.subject | Risk factors | - |
dc.title | Co-existing malignant lesions in atypical ductal hyperplasia – Pathology, probability, predictors and prognosis | - |
dc.type | Article | - |
dc.identifier.email | Co, M: mcth@hku.hk | - |
dc.identifier.email | Kwong, A: avakwong@hku.hk | - |
dc.identifier.authority | Co, M=rp02101 | - |
dc.identifier.authority | Kwong, A=rp01734 | - |
dc.description.nature | published_or_final_version | - |
dc.identifier.doi | 10.1016/j.asjsur.2019.04.015 | - |
dc.identifier.scopus | eid_2-s2.0-85065903918 | - |
dc.identifier.hkuros | 298165 | - |
dc.identifier.hkuros | 309922 | - |
dc.identifier.volume | 43 | - |
dc.identifier.spage | 240 | - |
dc.identifier.epage | 243 | - |
dc.identifier.isi | WOS:000509483400032 | - |
dc.publisher.place | Hong Kong | - |
dc.identifier.issnl | 1015-9584 | - |