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Conference Paper: Postnatal refinement of circuit plasticity for spatial navigation
Title | Postnatal refinement of circuit plasticity for spatial navigation |
---|---|
Authors | |
Issue Date | 2019 |
Publisher | Springer. The Journal's web site is located at https://link.springer.com/journal/12576 |
Citation | Proceedings of the 9th Federation of the Asian and Oceanian Physiological Society Congress (FAOPS2019) in conjunction with the 96th Annual Meeting of The Physiological Society of Japan: Philosophy of Life: Function and Mechanisms, Kobe, Japan, 28-31 March 2019. In Journal of Physiological Sciences, 2019, v. 69 n. Suppl. 1, p. S16, abstract no. S7-3 How to Cite? |
Abstract | The formation and consolidation of neural networks for a specific function are dependent on
maturation of synaptic elements in the circuit. We hypothesize that synaptic efficacy of vestibular
neurons undergoes postnatal tuning to sharpen spatial coding for the presentation of relevant
behaviors. Whole-cell patch-clamp data from the vestibular nucleus (VN) of neonatal rodents
indicated that endocannabinoid, serotonin and orexin could tune the efficacy of GABA
transmission. The impact of such neuromodulators on postnatal emergence of vestibular-
dependent graviceptive reflex was revealed using specific agonist/antagonist delivered to the
neonatal VN; the deficits in spatial cognition so caused lasted well into adulthood. However,
similar perturbations in juvenile animals posed no effect. To study whether the observed effects
were due to perturbation of GABA circuits, we directly attenuated GABA transmission in the
neonatal VN and found similar behavioral deficits. Optogenetic activation of inhibitory VN
interneurons in these animals revealed permanent reorganization of inhibitory input to projection
neurons. We reason that this underlies derangement of spatial maps in the forebrain of the
experimental animals with spatial cognition deficits. Altogether, we show that neuro modulators
tune GABA transmission and are instrumental in developmental consolidation of the vestibular
circuitry for spatial recognition. |
Description | Symposium7 (S7) From synaptic and network plasticity to behavior - no. S7-3 |
Persistent Identifier | http://hdl.handle.net/10722/272767 |
ISSN | 2023 Impact Factor: 2.6 2023 SCImago Journal Rankings: 0.709 |
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Chan, YS | - |
dc.contributor.author | Wu, LK | - |
dc.contributor.author | Shi, W | - |
dc.contributor.author | Jiang, Q | - |
dc.contributor.author | Ma, CW | - |
dc.contributor.author | Shum, DKY | - |
dc.date.accessioned | 2019-08-06T09:16:11Z | - |
dc.date.available | 2019-08-06T09:16:11Z | - |
dc.date.issued | 2019 | - |
dc.identifier.citation | Proceedings of the 9th Federation of the Asian and Oceanian Physiological Society Congress (FAOPS2019) in conjunction with the 96th Annual Meeting of The Physiological Society of Japan: Philosophy of Life: Function and Mechanisms, Kobe, Japan, 28-31 March 2019. In Journal of Physiological Sciences, 2019, v. 69 n. Suppl. 1, p. S16, abstract no. S7-3 | - |
dc.identifier.issn | 1880-6546 | - |
dc.identifier.uri | http://hdl.handle.net/10722/272767 | - |
dc.description | Symposium7 (S7) From synaptic and network plasticity to behavior - no. S7-3 | - |
dc.description.abstract | The formation and consolidation of neural networks for a specific function are dependent on maturation of synaptic elements in the circuit. We hypothesize that synaptic efficacy of vestibular neurons undergoes postnatal tuning to sharpen spatial coding for the presentation of relevant behaviors. Whole-cell patch-clamp data from the vestibular nucleus (VN) of neonatal rodents indicated that endocannabinoid, serotonin and orexin could tune the efficacy of GABA transmission. The impact of such neuromodulators on postnatal emergence of vestibular- dependent graviceptive reflex was revealed using specific agonist/antagonist delivered to the neonatal VN; the deficits in spatial cognition so caused lasted well into adulthood. However, similar perturbations in juvenile animals posed no effect. To study whether the observed effects were due to perturbation of GABA circuits, we directly attenuated GABA transmission in the neonatal VN and found similar behavioral deficits. Optogenetic activation of inhibitory VN interneurons in these animals revealed permanent reorganization of inhibitory input to projection neurons. We reason that this underlies derangement of spatial maps in the forebrain of the experimental animals with spatial cognition deficits. Altogether, we show that neuro modulators tune GABA transmission and are instrumental in developmental consolidation of the vestibular circuitry for spatial recognition. | - |
dc.language | eng | - |
dc.publisher | Springer. The Journal's web site is located at https://link.springer.com/journal/12576 | - |
dc.relation.ispartof | 9th Federation of the Asian and Oceanian Physiological Society Congress (FAOPS2019) | - |
dc.relation.ispartof | Journal of Physiological Sciences | - |
dc.title | Postnatal refinement of circuit plasticity for spatial navigation | - |
dc.type | Conference_Paper | - |
dc.identifier.email | Chan, YS: yschan@hku.hk | - |
dc.identifier.email | Wu, LK: lwu03@hku.hk | - |
dc.identifier.email | Ma, CW: cwma2010@hku.hk | - |
dc.identifier.email | Shum, DKY: shumdkhk@hkucc.hku.hk | - |
dc.identifier.authority | Chan, YS=rp00318 | - |
dc.identifier.authority | Shum, DKY=rp00321 | - |
dc.identifier.hkuros | 300597 | - |
dc.identifier.volume | 69 | - |
dc.identifier.issue | Suppl. 1 | - |
dc.identifier.spage | S16 | - |
dc.identifier.epage | S16 | - |
dc.publisher.place | Japan | - |
dc.identifier.issnl | 1880-6546 | - |