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Conference Paper: Prediction of treatment response following transarterial chemoembolization in patients with HCC using dualtracer positron emission tomography

TitlePrediction of treatment response following transarterial chemoembolization in patients with HCC using dualtracer positron emission tomography
Authors
Issue Date2019
PublisherSpringerOpen. The Journal's web site is located at http://www.springer.com/medicine/radiology/journal/13244
Citation
30th European Society of Gastrointestinal and Abdominal Radiology Annual Meeting (ESGAR 2019), Rome, Italy, 5-8 June 2019. In Insights into Imaging, 2019, v. 10 n. Suppl. 2, p. 20, article no. SS 5.6 How to Cite?
AbstractPurpose: While dual-tracer positron emission tomography (DT-PET) with 18F-FDG and 11C-acetate is highly sensitive in detecting HCC, its ability to prognosticate outcomes has not been previously explored. This study aims to evaluate whether DT-PET can predict treatment response in patients with HCC undergoing transarterial chemoembolization (TACE). Material and methods: Patients with HCC who had undergone DT-PET prior to TACE were retrospectively identified. Patient demographics, radiotracer uptake patterns, treatment response as per modified Response Evaluation Criteria In Solid Tumours (mRECIST), progression-free (PFS) and overall (OS) survival were analysed. Results: Between 2015 and 2018, 28 patients (M:F 22:6, median age 64) with 38 target lesions were included. Ten patients had multifocal while 18 had a solitary HCC (median size 19mm). 18F-FDG and 11C-acetate avidities were seen in 37% and 79% of HCC, respectively. Patients who responded to treatment had significantly longer OS (median 47.3 vs 20.9 months, p=0.022) while FDG uptake was associated with shorter PFS (median 2.7 vs 20.8 months, p=0.013) and OS (median 22.3 vs 44.7 months, p=0.008). Baseline raised AFP and multifocal disease were also associated with poorer OS. Lesion-based analysis showed acetate uptake (defined as tumour-to-liver ratio <2 for low or >2 for high) was predictive of treatment response (78% vs 47%, p=0.045). Conclusion: Our study shows that HCC with high acetate uptake is associated with less favourable response to TACE on a per lesion basis while FDG uptake in HCC is associated with shorter PFS and OS. DT-PET can potentially be a novel prognostic biomarker in the era of precision medicine.
DescriptionPresentation Number - SS 5.6
V. 10, suppl. 2 has special title: ESGAR 2019 Book of Abstracts
Persistent Identifierhttp://hdl.handle.net/10722/275243
ISSN
2023 Impact Factor: 4.1
2023 SCImago Journal Rankings: 1.240

 

DC FieldValueLanguage
dc.contributor.authorChiu, WHK-
dc.contributor.authorYuan, H-
dc.contributor.authorVan Lunenburg, JTJ-
dc.contributor.authorVardhanabhuti, V-
dc.contributor.authorTse, D-
dc.contributor.authorLee, EYP-
dc.date.accessioned2019-09-10T02:38:34Z-
dc.date.available2019-09-10T02:38:34Z-
dc.date.issued2019-
dc.identifier.citation30th European Society of Gastrointestinal and Abdominal Radiology Annual Meeting (ESGAR 2019), Rome, Italy, 5-8 June 2019. In Insights into Imaging, 2019, v. 10 n. Suppl. 2, p. 20, article no. SS 5.6-
dc.identifier.issn1869-4101-
dc.identifier.urihttp://hdl.handle.net/10722/275243-
dc.descriptionPresentation Number - SS 5.6-
dc.descriptionV. 10, suppl. 2 has special title: ESGAR 2019 Book of Abstracts-
dc.description.abstractPurpose: While dual-tracer positron emission tomography (DT-PET) with 18F-FDG and 11C-acetate is highly sensitive in detecting HCC, its ability to prognosticate outcomes has not been previously explored. This study aims to evaluate whether DT-PET can predict treatment response in patients with HCC undergoing transarterial chemoembolization (TACE). Material and methods: Patients with HCC who had undergone DT-PET prior to TACE were retrospectively identified. Patient demographics, radiotracer uptake patterns, treatment response as per modified Response Evaluation Criteria In Solid Tumours (mRECIST), progression-free (PFS) and overall (OS) survival were analysed. Results: Between 2015 and 2018, 28 patients (M:F 22:6, median age 64) with 38 target lesions were included. Ten patients had multifocal while 18 had a solitary HCC (median size 19mm). 18F-FDG and 11C-acetate avidities were seen in 37% and 79% of HCC, respectively. Patients who responded to treatment had significantly longer OS (median 47.3 vs 20.9 months, p=0.022) while FDG uptake was associated with shorter PFS (median 2.7 vs 20.8 months, p=0.013) and OS (median 22.3 vs 44.7 months, p=0.008). Baseline raised AFP and multifocal disease were also associated with poorer OS. Lesion-based analysis showed acetate uptake (defined as tumour-to-liver ratio <2 for low or >2 for high) was predictive of treatment response (78% vs 47%, p=0.045). Conclusion: Our study shows that HCC with high acetate uptake is associated with less favourable response to TACE on a per lesion basis while FDG uptake in HCC is associated with shorter PFS and OS. DT-PET can potentially be a novel prognostic biomarker in the era of precision medicine.-
dc.languageeng-
dc.publisherSpringerOpen. The Journal's web site is located at http://www.springer.com/medicine/radiology/journal/13244-
dc.relation.ispartofInsights into Imaging-
dc.relation.ispartofEuropean Society of Gastrointestinal and Abdominal Radiology (ESGAR) Annual Meeting, 2019-
dc.titlePrediction of treatment response following transarterial chemoembolization in patients with HCC using dualtracer positron emission tomography-
dc.typeConference_Paper-
dc.identifier.emailChiu, WHK: kwhchiu@hku.hk-
dc.identifier.emailYuan, H: oliveryh@HKUCC-COM.hku.hk-
dc.identifier.emailVardhanabhuti, V: varv@hku.hk-
dc.identifier.emailLee, EYP: eyplee77@hku.hk-
dc.identifier.authorityChiu, WHK=rp02074-
dc.identifier.authorityVardhanabhuti, V=rp01900-
dc.identifier.authorityLee, EYP=rp01456-
dc.identifier.hkuros303947-
dc.identifier.volume10-
dc.identifier.issueSuppl. 2-
dc.identifier.spage20, article no. SS 5.6-
dc.identifier.epage20, article no. SS 5.6-
dc.publisher.placeGermany-
dc.identifier.issnl1869-4101-

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