File Download
Links for fulltext
(May Require Subscription)
- Publisher Website: 10.1073/pnas.1812453116
- Scopus: eid_2-s2.0-85065730565
- PMID: 31028140
- WOS: WOS:000467804000066
- Find via
Supplementary
- Citations:
- Appears in Collections:
Article: Optogenetic fMRI interrogation of brain-wide central vestibular pathways
Title | Optogenetic fMRI interrogation of brain-wide central vestibular pathways |
---|---|
Authors | |
Keywords | fMRI vestibular system optogenetic medial vestibular nucleus vestibular functions |
Issue Date | 2019 |
Publisher | National Academy of Sciences. The Journal's web site is located at http://www.pnas.org |
Citation | Proceedings of the National Academy of Sciences, 2019, v. 116 n. 20, p. 10122-10129 How to Cite? |
Abstract | Blood oxygen level-dependent functional MRI (fMRI) constitutes a powerful neuroimaging technology to map brain-wide functions in response to specific sensory or cognitive tasks. However, fMRI mapping of the vestibular system, which is pivotal for our sense of balance, poses significant challenges. Physical constraints limit a subject’s ability to perform motion- and balance-related tasks inside the scanner, and current stimulation techniques within the scanner are nonspecific to delineate complex vestibular nucleus (VN) pathways. Using fMRI, we examined brain-wide neural activity patterns elicited by optogenetically stimulating excitatory neurons of a major vestibular nucleus, the ipsilateral medial VN (MVN). We demonstrated robust optogenetically evoked fMRI activations bilaterally at sensorimotor cortices and their associated thalamic nuclei (auditory, visual, somatosensory, and motor), high-order cortices (cingulate, retrosplenial, temporal association, and parietal), and hippocampal formations (dentate gyrus, entorhinal cortex, and subiculum). We then examined the modulatory effects of the vestibular system on sensory processing using auditory and visual stimulation in combination with optogenetic excitation of the MVN. We found enhanced responses to sound in the auditory cortex, thalamus, and inferior colliculus ipsilateral to the stimulated MVN. In the visual pathway, we observed enhanced responses to visual stimuli in the ipsilateral visual cortex, thalamus, and contralateral superior colliculus. Taken together, our imaging findings reveal multiple brain-wide central vestibular pathways. We demonstrate large-scale modulatory effects of the vestibular system on sensory processing. |
Persistent Identifier | http://hdl.handle.net/10722/279034 |
ISSN | 2023 Impact Factor: 9.4 2023 SCImago Journal Rankings: 3.737 |
PubMed Central ID | |
ISI Accession Number ID |
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Leong, ATL | - |
dc.contributor.author | Gu, Y | - |
dc.contributor.author | Chan, YS | - |
dc.contributor.author | Zheng, H | - |
dc.contributor.author | DONG, CM | - |
dc.contributor.author | Chan, RW | - |
dc.contributor.author | WANG, X | - |
dc.contributor.author | Liu, Y | - |
dc.contributor.author | Tan, LH | - |
dc.contributor.author | Wu, EX | - |
dc.date.accessioned | 2019-10-21T02:18:25Z | - |
dc.date.available | 2019-10-21T02:18:25Z | - |
dc.date.issued | 2019 | - |
dc.identifier.citation | Proceedings of the National Academy of Sciences, 2019, v. 116 n. 20, p. 10122-10129 | - |
dc.identifier.issn | 0027-8424 | - |
dc.identifier.uri | http://hdl.handle.net/10722/279034 | - |
dc.description.abstract | Blood oxygen level-dependent functional MRI (fMRI) constitutes a powerful neuroimaging technology to map brain-wide functions in response to specific sensory or cognitive tasks. However, fMRI mapping of the vestibular system, which is pivotal for our sense of balance, poses significant challenges. Physical constraints limit a subject’s ability to perform motion- and balance-related tasks inside the scanner, and current stimulation techniques within the scanner are nonspecific to delineate complex vestibular nucleus (VN) pathways. Using fMRI, we examined brain-wide neural activity patterns elicited by optogenetically stimulating excitatory neurons of a major vestibular nucleus, the ipsilateral medial VN (MVN). We demonstrated robust optogenetically evoked fMRI activations bilaterally at sensorimotor cortices and their associated thalamic nuclei (auditory, visual, somatosensory, and motor), high-order cortices (cingulate, retrosplenial, temporal association, and parietal), and hippocampal formations (dentate gyrus, entorhinal cortex, and subiculum). We then examined the modulatory effects of the vestibular system on sensory processing using auditory and visual stimulation in combination with optogenetic excitation of the MVN. We found enhanced responses to sound in the auditory cortex, thalamus, and inferior colliculus ipsilateral to the stimulated MVN. In the visual pathway, we observed enhanced responses to visual stimuli in the ipsilateral visual cortex, thalamus, and contralateral superior colliculus. Taken together, our imaging findings reveal multiple brain-wide central vestibular pathways. We demonstrate large-scale modulatory effects of the vestibular system on sensory processing. | - |
dc.language | eng | - |
dc.publisher | National Academy of Sciences. The Journal's web site is located at http://www.pnas.org | - |
dc.relation.ispartof | Proceedings of the National Academy of Sciences | - |
dc.rights | Proceedings of the National Academy of Sciences. Copyright © National Academy of Sciences. | - |
dc.subject | fMRI | - |
dc.subject | vestibular system | - |
dc.subject | optogenetic | - |
dc.subject | medial vestibular nucleus | - |
dc.subject | vestibular functions | - |
dc.title | Optogenetic fMRI interrogation of brain-wide central vestibular pathways | - |
dc.type | Article | - |
dc.identifier.email | Leong, ATL: tlleong@hku.hk | - |
dc.identifier.email | Chan, YS: yschan@hku.hk | - |
dc.identifier.email | Liu, Y: loyalliu@hku.hk | - |
dc.identifier.email | Wu, EX: ewu@eee.hku.hk | - |
dc.identifier.authority | Leong, ATL=rp02483 | - |
dc.identifier.authority | Chan, YS=rp00318 | - |
dc.identifier.authority | Wu, EX=rp00193 | - |
dc.description.nature | link_to_OA_fulltext | - |
dc.identifier.doi | 10.1073/pnas.1812453116 | - |
dc.identifier.pmid | 31028140 | - |
dc.identifier.pmcid | PMC6525493 | - |
dc.identifier.scopus | eid_2-s2.0-85065730565 | - |
dc.identifier.hkuros | 307645 | - |
dc.identifier.volume | 116 | - |
dc.identifier.issue | 20 | - |
dc.identifier.spage | 10122 | - |
dc.identifier.epage | 10129 | - |
dc.identifier.isi | WOS:000467804000066 | - |
dc.publisher.place | United States | - |
dc.identifier.issnl | 0027-8424 | - |