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- Publisher Website: 10.1158/0008-5472.CAN-19-1840
- Scopus: eid_2-s2.0-85079022145
- PMID: 31723001
- WOS: WOS:000514161100024
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Article: Association of genomic domains in BRCA1 and BRCA2 with prostate cancer risk and aggressiveness
Title | Association of genomic domains in BRCA1 and BRCA2 with prostate cancer risk and aggressiveness |
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Authors | |
Keywords | MESSENGER-RNA DECAY BREAST-CANCER GERMLINE MUTATIONS GENE OVARIAN |
Issue Date | 2020 |
Publisher | American Association for Cancer Research. The Journal's web site is located at http://cancerres.aacrjournals.org/ |
Citation | Cancer Research, 2020, v. 80 n. 3, p. 624-638 How to Cite? |
Abstract | Pathogenic sequence variants (PSV) in BRCA1 or BRCA2 (BRCA1/2) are associated with increased risk and severity of prostate cancer. We evaluated whether PSVs in BRCA1/2 were associated with risk of overall prostate cancer or high grade (Gleason 8þ) prostate cancer using an international sample of 65 BRCA1 and 171 BRCA2 male PSV carriers with prostate cancer, and 3,388 BRCA1 and 2,880 BRCA2 male PSV carriers without prostate cancer. PSVs in the 30 region of BRCA2 (c.7914þ) were significantly associated with elevated risk of prostate cancer compared with reference bin c.1001c.7913 [HR ¼ 1.78; 95% confidence interval (CI), 1.25–2.52; P ¼ 0.001], as well as elevated risk of Gleason 8þ prostate cancer (HR ¼ 3.11; 95% CI, 1.63–5.95; P ¼ 0.001). c.756-c.1000 was also associated with elevated prostate cancer risk (HR ¼ 2.83; 95% CI, 1.71–4.68; P ¼ 0.00004) and elevated risk of Gleason 8þ prostate cancer (HR ¼ 4.95; 95% CI, 2.12–11.54; P ¼ 0.0002). No genotype–phenotype associations were detected for PSVs in BRCA1. These results demonstrate that specific BRCA2 PSVs may be associated with elevated risk of developing aggressive prostate cancer. © 2020 American Association for Cancer Research. |
Persistent Identifier | http://hdl.handle.net/10722/281178 |
ISSN | 2023 Impact Factor: 12.5 2023 SCImago Journal Rankings: 3.468 |
ISI Accession Number ID |
DC Field | Value | Language |
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dc.contributor.author | Patel, VL | - |
dc.contributor.author | Busch, EL | - |
dc.contributor.author | Friebel, TM | - |
dc.contributor.author | Kwong, A | - |
dc.contributor.author | Shin, VY | - |
dc.date.accessioned | 2020-03-09T09:51:14Z | - |
dc.date.available | 2020-03-09T09:51:14Z | - |
dc.date.issued | 2020 | - |
dc.identifier.citation | Cancer Research, 2020, v. 80 n. 3, p. 624-638 | - |
dc.identifier.issn | 0008-5472 | - |
dc.identifier.uri | http://hdl.handle.net/10722/281178 | - |
dc.description.abstract | Pathogenic sequence variants (PSV) in BRCA1 or BRCA2 (BRCA1/2) are associated with increased risk and severity of prostate cancer. We evaluated whether PSVs in BRCA1/2 were associated with risk of overall prostate cancer or high grade (Gleason 8þ) prostate cancer using an international sample of 65 BRCA1 and 171 BRCA2 male PSV carriers with prostate cancer, and 3,388 BRCA1 and 2,880 BRCA2 male PSV carriers without prostate cancer. PSVs in the 30 region of BRCA2 (c.7914þ) were significantly associated with elevated risk of prostate cancer compared with reference bin c.1001c.7913 [HR ¼ 1.78; 95% confidence interval (CI), 1.25–2.52; P ¼ 0.001], as well as elevated risk of Gleason 8þ prostate cancer (HR ¼ 3.11; 95% CI, 1.63–5.95; P ¼ 0.001). c.756-c.1000 was also associated with elevated prostate cancer risk (HR ¼ 2.83; 95% CI, 1.71–4.68; P ¼ 0.00004) and elevated risk of Gleason 8þ prostate cancer (HR ¼ 4.95; 95% CI, 2.12–11.54; P ¼ 0.0002). No genotype–phenotype associations were detected for PSVs in BRCA1. These results demonstrate that specific BRCA2 PSVs may be associated with elevated risk of developing aggressive prostate cancer. © 2020 American Association for Cancer Research. | - |
dc.language | eng | - |
dc.publisher | American Association for Cancer Research. The Journal's web site is located at http://cancerres.aacrjournals.org/ | - |
dc.relation.ispartof | Cancer Research | - |
dc.subject | MESSENGER-RNA DECAY | - |
dc.subject | BREAST-CANCER | - |
dc.subject | GERMLINE MUTATIONS | - |
dc.subject | GENE | - |
dc.subject | OVARIAN | - |
dc.title | Association of genomic domains in BRCA1 and BRCA2 with prostate cancer risk and aggressiveness | - |
dc.type | Article | - |
dc.identifier.email | Kwong, A: avakwong@hku.hk | - |
dc.identifier.email | Shin, VY: vyshin@hku.hk | - |
dc.identifier.authority | Kwong, A=rp01734 | - |
dc.identifier.authority | Shin, VY=rp02000 | - |
dc.description.nature | link_to_subscribed_fulltext | - |
dc.identifier.doi | 10.1158/0008-5472.CAN-19-1840 | - |
dc.identifier.pmid | 31723001 | - |
dc.identifier.scopus | eid_2-s2.0-85079022145 | - |
dc.identifier.hkuros | 309357 | - |
dc.identifier.volume | 80 | - |
dc.identifier.issue | 3 | - |
dc.identifier.spage | 624 | - |
dc.identifier.epage | 638 | - |
dc.identifier.isi | WOS:000514161100024 | - |
dc.publisher.place | United States | - |
dc.identifier.issnl | 0008-5472 | - |