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Article: Distribution of lymph node metastases in esophageal carcinoma [TIGER study]: study protocol of a multinational observational study

TitleDistribution of lymph node metastases in esophageal carcinoma [TIGER study]: study protocol of a multinational observational study
Authors
KeywordsEsophageal cancer
Lymph node metastases
Lymphadenectomy
Esophagectomy
Issue Date2019
PublisherBioMed Central Ltd. The Journal's web site is located at http://www.biomedcentral.com/bmccancer/
Citation
BMC Cancer, 2019, v. 19 n. 1, p. article no. 662 How to Cite?
AbstractBackground An important parameter for survival in patients with esophageal carcinoma is lymph node status. The distribution of lymph node metastases depends on tumor characteristics such as tumor location, histology, invasion depth, and on neoadjuvant treatment. The exact distribution is unknown. Neoadjuvant treatment and surgical strategy depends on the distribution pattern of nodal metastases but consensus on the extent of lymphadenectomy has not been reached. The aim of this study is to determine the distribution of lymph node metastases in patients with resectable esophageal or gastro-esophageal junction carcinoma in whom a transthoracic esophagectomy with a 2- or 3-field lymphadenectomy is performed. This can be the foundation for a uniform worldwide staging system and establishment of the optimal surgical strategy for esophageal cancer patients. Methods: The TIGER study is an international observational cohort study with 50 participating centers. Patients with a resectable esophageal or gastro-esophageal junction carcinoma in whom a transthoracic esophagectomy with a 2- or 3-field lymphadenectomy is performed in participating centers will be included. All lymph node stations will be excised and separately individually analyzed by pathological examination. The aim is to include 5000 patients. The primary endpoint is the distribution of lymph node metastases in esophageal and esophago-gastric junction carcinoma specimens following transthoracic esophagectomy with at least 2-field lymphadenectomy in relation to tumor histology, tumor location, invasion depth, number of lymph nodes and lymph node metastases, pre-operative diagnostics, neo-adjuvant therapy and (disease free) survival. Discussion: The TIGER study will provide a roadmap of the location of lymph node metastases in relation to tumor histology, tumor location, invasion depth, number of lymph nodes and lymph node metastases, pre-operative diagnostics, neo-adjuvant therapy and survival. Patient-tailored treatment can be developed based on these results, such as the optimal radiation field and extent of lymphadenectomy based on the primary tumor characteristics. Trial registration: NCT03222895, date of registration: July 19th, 2017.
Persistent Identifierhttp://hdl.handle.net/10722/281907
ISSN
2018 Impact Factor: 2.933
2015 SCImago Journal Rankings: 1.627
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorHagens, ERC-
dc.contributor.authorvan Berge Henegouwen, MI-
dc.contributor.authorvan Sandick, JW-
dc.contributor.authorCuesta, MA-
dc.contributor.authorvan der Peet, DL-
dc.contributor.authorHeisterkamp, J-
dc.contributor.authorNieuwenhuilzen, GAP-
dc.contributor.authorRoman, C-
dc.contributor.authorScheepers, JJG-
dc.contributor.authorSosef, MN-
dc.contributor.authorvan Hillegersberg, R-
dc.contributor.authorLagarde, SM-
dc.contributor.authorNilsson, M-
dc.contributor.authorRasanen, J-
dc.contributor.authorNafteux, P-
dc.contributor.authorPattyn, P-
dc.contributor.authorHolscher, AH-
dc.contributor.authorSchroder, W-
dc.contributor.authorSchneider, PM-
dc.contributor.authorMariette, C-
dc.contributor.authorCastoro, C-
dc.contributor.authorBonavina, L-
dc.contributor.authorRosati, R-
dc.contributor.authorde Manzoni, G-
dc.contributor.authorMattioli, S-
dc.contributor.authorGarcia, JR-
dc.contributor.authorPera, M-
dc.contributor.authorGriffin, M-
dc.contributor.authorWilkerson, P-
dc.contributor.authorChaudry, MA-
dc.contributor.authorSgromo, B-
dc.contributor.authorTucker, O-
dc.contributor.authorCheong, E-
dc.contributor.authorMoorthy, K-
dc.contributor.authorWalsh, TN-
dc.contributor.authorReynolds, J-
dc.contributor.authorTachimori, Y-
dc.contributor.authorInoue, H-
dc.contributor.authorMatsubara, H-
dc.contributor.authorKosugi, SI-
dc.contributor.authorKuppusamy, MK-
dc.contributor.authorChen, H-
dc.contributor.authorLaw, SYK-
dc.contributor.authorPramesh, CS-
dc.contributor.authorPuntambekar, SP-
dc.contributor.authorMurthy, S-
dc.contributor.authorLinden, P-
dc.contributor.authorHofstetter, WL-
dc.contributor.authorShen, KR-
dc.contributor.authorDarling, GE-
dc.contributor.authorSabino, FD-
dc.contributor.authorGrimminger, PP-
dc.contributor.authorMeijer, SL-
dc.contributor.authorBergman, JJGHM-
dc.contributor.authorHulshof, MCCM-
dc.contributor.authorvan Laarhoven, HWM-
dc.contributor.authorMearadji, B-
dc.contributor.authorBennink, RJ-
dc.contributor.authorAnnema, JT-
dc.contributor.authorDijkgraaf, MGW-
dc.contributor.authorGisbertz, SS-
dc.date.accessioned2020-04-03T07:23:28Z-
dc.date.available2020-04-03T07:23:28Z-
dc.date.issued2019-
dc.identifier.citationBMC Cancer, 2019, v. 19 n. 1, p. article no. 662-
dc.identifier.issn1471-2407-
dc.identifier.urihttp://hdl.handle.net/10722/281907-
dc.description.abstractBackground An important parameter for survival in patients with esophageal carcinoma is lymph node status. The distribution of lymph node metastases depends on tumor characteristics such as tumor location, histology, invasion depth, and on neoadjuvant treatment. The exact distribution is unknown. Neoadjuvant treatment and surgical strategy depends on the distribution pattern of nodal metastases but consensus on the extent of lymphadenectomy has not been reached. The aim of this study is to determine the distribution of lymph node metastases in patients with resectable esophageal or gastro-esophageal junction carcinoma in whom a transthoracic esophagectomy with a 2- or 3-field lymphadenectomy is performed. This can be the foundation for a uniform worldwide staging system and establishment of the optimal surgical strategy for esophageal cancer patients. Methods: The TIGER study is an international observational cohort study with 50 participating centers. Patients with a resectable esophageal or gastro-esophageal junction carcinoma in whom a transthoracic esophagectomy with a 2- or 3-field lymphadenectomy is performed in participating centers will be included. All lymph node stations will be excised and separately individually analyzed by pathological examination. The aim is to include 5000 patients. The primary endpoint is the distribution of lymph node metastases in esophageal and esophago-gastric junction carcinoma specimens following transthoracic esophagectomy with at least 2-field lymphadenectomy in relation to tumor histology, tumor location, invasion depth, number of lymph nodes and lymph node metastases, pre-operative diagnostics, neo-adjuvant therapy and (disease free) survival. Discussion: The TIGER study will provide a roadmap of the location of lymph node metastases in relation to tumor histology, tumor location, invasion depth, number of lymph nodes and lymph node metastases, pre-operative diagnostics, neo-adjuvant therapy and survival. Patient-tailored treatment can be developed based on these results, such as the optimal radiation field and extent of lymphadenectomy based on the primary tumor characteristics. Trial registration: NCT03222895, date of registration: July 19th, 2017.-
dc.languageeng-
dc.publisherBioMed Central Ltd. The Journal's web site is located at http://www.biomedcentral.com/bmccancer/-
dc.relation.ispartofBMC Cancer-
dc.rightsBMC Cancer. Copyright © BioMed Central Ltd.-
dc.rightsThis work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.-
dc.subjectEsophageal cancer-
dc.subjectLymph node metastases-
dc.subjectLymphadenectomy-
dc.subjectEsophagectomy-
dc.titleDistribution of lymph node metastases in esophageal carcinoma [TIGER study]: study protocol of a multinational observational study-
dc.typeArticle-
dc.identifier.emailLaw, SYK: slaw@hku.hk-
dc.identifier.authorityLaw, SYK=rp00437-
dc.description.naturepublished_or_final_version-
dc.identifier.doi10.1186/s12885-019-5761-7-
dc.identifier.pmid31272485-
dc.identifier.scopuseid_2-s2.0-85068550057-
dc.identifier.hkuros309691-
dc.identifier.volume19-
dc.identifier.issue1-
dc.identifier.spagearticle no. 662-
dc.identifier.epagearticle no. 662-
dc.identifier.isiWOS:000474544500006-
dc.publisher.placeUnited Kingdom-
dc.identifier.issnl1471-2407-

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