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- Publisher Website: 10.1007/s00381-019-04480-x
- Scopus: eid_2-s2.0-85078334209
- PMID: 31974662
- WOS: WOS:000514537800009
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Article: Outcome of Chinese children with craniopharyngioma: a 20-year population-based study by the Hong Kong pediatric hematology/oncology study group
Title | Outcome of Chinese children with craniopharyngioma: a 20-year population-based study by the Hong Kong pediatric hematology/oncology study group |
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Authors | |
Keywords | Craniopharyngioma Pediatric Chinese Radiotherapy Endocrinopathy |
Issue Date | 2020 |
Publisher | Springer Verlag. The Journal's web site is located at http://link.springer.de/link/service/journals/00381/index.htm |
Citation | Child's Nervous System, 2020, v. 36 n. 3, p. 497-505 How to Cite? |
Abstract | Purpose:
Craniopharyngioma is a rare low-grade neoplasm in children. Tumor progression occurs frequently, and survivors are at risk of long-term disease and treatment-related morbidities. We reviewed the population-based experience of managing pediatric craniopharyngioma in Hong Kong.
Methods:
The Hong Kong Pediatric Hematology/Oncology Study Group database was interrogated for patients with craniopharyngioma younger than 18 years between 1999 and 2018. Patient demographics, clinical characteristics, outcomes, and long-term morbidities were summarized.
Results:
Twenty-eight patients with craniopharyngioma were included (approximate incidence of 1.1 per 1,000,000 individuals). The treatment approaches were heterogeneous and included surgery only, surgery with adjuvant radiation, and surgery with intracystic interferon. With a median follow-up of 6.1 years, 12 (43%) patients experienced disease progression, and 3 patients died of progression, postoperative complication, and gastrointestinal bleeding. The 5-year progression-free survival (PFS) and overall survival (OS) rates were 56.8% (± 10.0%) and 92.0% (± 5.4%), respectively. The 10-year PFS and OS rates were 37.3% (± 11.4) and 92.0% (± 5.4%), respectively. Patients receiving treatment in a high-volume center had significantly better outcomes than did those treated at other centers (PFS, p = 0.007; OS, p = 0.029). Period of diagnosis, sex, age at diagnosis, greatest tumor dimension, extent of resection, and radiotherapy use did not significantly affect patient survival. Long-term visual impairment (60%) and endocrinopathies (92%) were common.
Conclusion:
Prognosis of pediatric craniopharyngioma in Hong Kong compares unfavorably with published reports. Centralization and standardization of treatment may prove valuable in mitigating patient outcomes. |
Persistent Identifier | http://hdl.handle.net/10722/282524 |
ISSN | 2023 Impact Factor: 1.3 2023 SCImago Journal Rankings: 0.518 |
ISI Accession Number ID |
DC Field | Value | Language |
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dc.contributor.author | Liu, AP-Y | - |
dc.contributor.author | Tung, JY-L | - |
dc.contributor.author | Ku, DT-L | - |
dc.contributor.author | Luk, C-W | - |
dc.contributor.author | Ling, AS-C | - |
dc.contributor.author | Kwong, DL-W | - |
dc.contributor.author | Cheng, KF-F | - |
dc.contributor.author | Ho, WW-S | - |
dc.contributor.author | Shing, MM-K | - |
dc.contributor.author | Chan, GC-F | - |
dc.date.accessioned | 2020-05-15T05:29:14Z | - |
dc.date.available | 2020-05-15T05:29:14Z | - |
dc.date.issued | 2020 | - |
dc.identifier.citation | Child's Nervous System, 2020, v. 36 n. 3, p. 497-505 | - |
dc.identifier.issn | 0256-7040 | - |
dc.identifier.uri | http://hdl.handle.net/10722/282524 | - |
dc.description.abstract | Purpose: Craniopharyngioma is a rare low-grade neoplasm in children. Tumor progression occurs frequently, and survivors are at risk of long-term disease and treatment-related morbidities. We reviewed the population-based experience of managing pediatric craniopharyngioma in Hong Kong. Methods: The Hong Kong Pediatric Hematology/Oncology Study Group database was interrogated for patients with craniopharyngioma younger than 18 years between 1999 and 2018. Patient demographics, clinical characteristics, outcomes, and long-term morbidities were summarized. Results: Twenty-eight patients with craniopharyngioma were included (approximate incidence of 1.1 per 1,000,000 individuals). The treatment approaches were heterogeneous and included surgery only, surgery with adjuvant radiation, and surgery with intracystic interferon. With a median follow-up of 6.1 years, 12 (43%) patients experienced disease progression, and 3 patients died of progression, postoperative complication, and gastrointestinal bleeding. The 5-year progression-free survival (PFS) and overall survival (OS) rates were 56.8% (± 10.0%) and 92.0% (± 5.4%), respectively. The 10-year PFS and OS rates were 37.3% (± 11.4) and 92.0% (± 5.4%), respectively. Patients receiving treatment in a high-volume center had significantly better outcomes than did those treated at other centers (PFS, p = 0.007; OS, p = 0.029). Period of diagnosis, sex, age at diagnosis, greatest tumor dimension, extent of resection, and radiotherapy use did not significantly affect patient survival. Long-term visual impairment (60%) and endocrinopathies (92%) were common. Conclusion: Prognosis of pediatric craniopharyngioma in Hong Kong compares unfavorably with published reports. Centralization and standardization of treatment may prove valuable in mitigating patient outcomes. | - |
dc.language | eng | - |
dc.publisher | Springer Verlag. The Journal's web site is located at http://link.springer.de/link/service/journals/00381/index.htm | - |
dc.relation.ispartof | Child's Nervous System | - |
dc.rights | This is a post-peer-review, pre-copyedit version of an article published in [insert journal title]. The final authenticated version is available online at: http://dx.doi.org/[insert DOI] | - |
dc.subject | Craniopharyngioma | - |
dc.subject | Pediatric | - |
dc.subject | Chinese | - |
dc.subject | Radiotherapy | - |
dc.subject | Endocrinopathy | - |
dc.title | Outcome of Chinese children with craniopharyngioma: a 20-year population-based study by the Hong Kong pediatric hematology/oncology study group | - |
dc.type | Article | - |
dc.identifier.email | Liu, AP-Y: apyliu@hku.hk | - |
dc.identifier.email | Tung, JY-L: tungylj@HKUCC-COM.hku.hk | - |
dc.identifier.email | Kwong, DL-W: dlwkwong@hku.hk | - |
dc.identifier.email | Cheng, KF-F: kfckevin@hku.hk | - |
dc.identifier.email | Ho, WW-S: howsw@hku.hk | - |
dc.identifier.email | Chan, GC-F: gcfchan@hku.hk | - |
dc.identifier.authority | Liu, AP-Y=rp01357 | - |
dc.identifier.authority | Kwong, DL-W=rp00414 | - |
dc.identifier.authority | Chan, GC-F=rp00431 | - |
dc.description.nature | link_to_subscribed_fulltext | - |
dc.identifier.doi | 10.1007/s00381-019-04480-x | - |
dc.identifier.pmid | 31974662 | - |
dc.identifier.scopus | eid_2-s2.0-85078334209 | - |
dc.identifier.hkuros | 309889 | - |
dc.identifier.volume | 36 | - |
dc.identifier.issue | 3 | - |
dc.identifier.spage | 497 | - |
dc.identifier.epage | 505 | - |
dc.identifier.isi | WOS:000514537800009 | - |
dc.publisher.place | Germany | - |
dc.identifier.issnl | 0256-7040 | - |