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- Publisher Website: 10.1016/j.acra.2019.09.019
- Scopus: eid_2-s2.0-85074067486
- PMID: 31629627
- WOS: WOS:000542679300010
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Article: The Value of Contrast-Enhanced CT in the Detection of Residual Disease After Neo-Adjuvant Chemotherapy in Ovarian Cancer
Title | The Value of Contrast-Enhanced CT in the Detection of Residual Disease After Neo-Adjuvant Chemotherapy in Ovarian Cancer |
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Authors | |
Keywords | Contrast-enhanced CT Interval debulking surgery Neo-adjuvant chemotherapy Ovarian cancer |
Issue Date | 2020 |
Publisher | Elsevier BV. The Journal's web site is located at http://www.elsevier.com/locate/arad |
Citation | Academic Radiology, 2020, v. 27 n. 7, p. 951-957 How to Cite? |
Abstract | Rationale and Objectives:
To evaluate the diagnostic performance of contrast-enhanced computed tomography (CT) in predicting residual disease following neo-adjuvant chemotherapy (NACT) in stage III/IV ovarian cancer.
Materials and Methods:
This was a retrospective observational cohort study including consecutive patients with primary stage III/IV ovarian cancer who received NACT before interval debulking surgery. CT findings before interval debulking surgerywere correlated with histological/surgical findings. Diagnostic characteristics were calculated on patient-based and lesion-based analyses. False negative results on peritoneal carcinomatosis detection were correlated with lesion size and site.
Results:
On patient-based analysis, CT (n = 58) had a sensitivity, specificity, positive predictive value, negative predictive value and accuracy of 92.16%, 57.14%, 94.00%, 50.00%, and 87.93%. On lesion-based analysis, the sensitivity, specificity, positive predictive value, negative predictive value, and accuracy were 63.01%, 73.47%, 82.51%, 50.00%, and 66.51%. False negative results were associated with lesion size (p < 0.001). The diagnostic performance of CT on the detection of peritoneal carcinomatosis was low at the subdiaphragmatic spaces, bowel serosa and mesentery (p < 0.001).
Conclusion:
CT had low negative predictive value in determining residual disease following NACT on both patient-based and lesion-based analyses, especially for non-measurable lesions and at the subdiaphragmatic spaces, bowel serosa and mesentery. |
Persistent Identifier | http://hdl.handle.net/10722/284049 |
ISSN | 2023 Impact Factor: 3.8 2023 SCImago Journal Rankings: 1.062 |
ISI Accession Number ID |
DC Field | Value | Language |
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dc.contributor.author | AN, H | - |
dc.contributor.author | Chiu, KWH | - |
dc.contributor.author | Tse, KY | - |
dc.contributor.author | Ngan, HYS | - |
dc.contributor.author | Khong, PL | - |
dc.contributor.author | Lee, EYP | - |
dc.date.accessioned | 2020-07-20T05:55:41Z | - |
dc.date.available | 2020-07-20T05:55:41Z | - |
dc.date.issued | 2020 | - |
dc.identifier.citation | Academic Radiology, 2020, v. 27 n. 7, p. 951-957 | - |
dc.identifier.issn | 1076-6332 | - |
dc.identifier.uri | http://hdl.handle.net/10722/284049 | - |
dc.description.abstract | Rationale and Objectives: To evaluate the diagnostic performance of contrast-enhanced computed tomography (CT) in predicting residual disease following neo-adjuvant chemotherapy (NACT) in stage III/IV ovarian cancer. Materials and Methods: This was a retrospective observational cohort study including consecutive patients with primary stage III/IV ovarian cancer who received NACT before interval debulking surgery. CT findings before interval debulking surgerywere correlated with histological/surgical findings. Diagnostic characteristics were calculated on patient-based and lesion-based analyses. False negative results on peritoneal carcinomatosis detection were correlated with lesion size and site. Results: On patient-based analysis, CT (n = 58) had a sensitivity, specificity, positive predictive value, negative predictive value and accuracy of 92.16%, 57.14%, 94.00%, 50.00%, and 87.93%. On lesion-based analysis, the sensitivity, specificity, positive predictive value, negative predictive value, and accuracy were 63.01%, 73.47%, 82.51%, 50.00%, and 66.51%. False negative results were associated with lesion size (p < 0.001). The diagnostic performance of CT on the detection of peritoneal carcinomatosis was low at the subdiaphragmatic spaces, bowel serosa and mesentery (p < 0.001). Conclusion: CT had low negative predictive value in determining residual disease following NACT on both patient-based and lesion-based analyses, especially for non-measurable lesions and at the subdiaphragmatic spaces, bowel serosa and mesentery. | - |
dc.language | eng | - |
dc.publisher | Elsevier BV. The Journal's web site is located at http://www.elsevier.com/locate/arad | - |
dc.relation.ispartof | Academic Radiology | - |
dc.subject | Contrast-enhanced CT | - |
dc.subject | Interval debulking surgery | - |
dc.subject | Neo-adjuvant chemotherapy | - |
dc.subject | Ovarian cancer | - |
dc.title | The Value of Contrast-Enhanced CT in the Detection of Residual Disease After Neo-Adjuvant Chemotherapy in Ovarian Cancer | - |
dc.type | Article | - |
dc.identifier.email | Chiu, KWH: kwhchiu@hku.hk | - |
dc.identifier.email | Tse, KY: tseky@hku.hk | - |
dc.identifier.email | Ngan, HYS: hysngan@hkucc.hku.hk | - |
dc.identifier.email | Khong, PL: plkhong@hku.hk | - |
dc.identifier.email | Lee, EYP: eyplee77@hku.hk | - |
dc.identifier.authority | Chiu, KWH=rp02074 | - |
dc.identifier.authority | Tse, KY=rp02391 | - |
dc.identifier.authority | Ngan, HYS=rp00346 | - |
dc.identifier.authority | Khong, PL=rp00467 | - |
dc.identifier.authority | Lee, EYP=rp01456 | - |
dc.description.nature | link_to_subscribed_fulltext | - |
dc.identifier.doi | 10.1016/j.acra.2019.09.019 | - |
dc.identifier.pmid | 31629627 | - |
dc.identifier.scopus | eid_2-s2.0-85074067486 | - |
dc.identifier.hkuros | 311318 | - |
dc.identifier.volume | 27 | - |
dc.identifier.issue | 7 | - |
dc.identifier.spage | 951 | - |
dc.identifier.epage | 957 | - |
dc.identifier.isi | WOS:000542679300010 | - |
dc.publisher.place | Netherlands | - |
dc.identifier.issnl | 1076-6332 | - |