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Article: Metabolic active peritoneal sites affect tumor debulking in ovarian and peritoneal cancers

TitleMetabolic active peritoneal sites affect tumor debulking in ovarian and peritoneal cancers
Authors
Keywords18F-FDG PET/CT
Ovarian and peritoneal cancers
Tumor debulking
Peritoneal carcinomatosis
Issue Date2020
PublisherBioMed Central Ltd. The Journal's web site is located at https://ovarianresearch.biomedcentral.com/
Citation
Journal of Ovarian Research, 2020, v. 13 n. 1, p. article no. 61 How to Cite?
AbstractRationale and objectives: To evaluate the impact of metabolic parameters in the peritoneal cavity on the likelihood of achieving complete tumor debulking in patients with ovarian and peritoneal cancers. Materials and methods: Forty-nine patients with ovarian and peritoneal cancers were included, who underwent pre-operative 18F-fluorodeoxyglucose Positron Emission Tomography/Computed Tomography (18F-FDG PET/CT). The immediate surgical outcome was dichotomized into complete and incomplete tumor debulking. 18F-FDG PET/CT was qualitatively and quantitatively assessed by scrutinizing 15 anatomical sites for the presence of peritoneal carcinomatosis (PC). Patient-based and site-based diagnostic characteristics were described. Metabolic parameters (SUVmax, metabolic tumor volume and total lesion glycolysis) and the number of 18F-FDG avid peritoneal sites were evaluated between the two groups. Receiver operating curve (ROC) analysis was performed to determine the optimal cut-off value in predicting incomplete tumor debulking. Results: Twenty-seven out of the 49 patients had PC and 11 had incomplete debulking. Patient-based and site-based accuracies for detection of PC were 87.8 and 97.6%, respectively. The number of 18F-FDG avid peritoneal sites was significantly different between complete and incomplete debulking groups (0.6 ± 0.8 versus 2.3 ± 1.7 sites respectively, p = 0.001), and the only independent significant risk factor among other metabolic parameters tested (odd ratio = 2.983, 95% CI 1.104–8.062) for incomplete tumor debulking with an optimal cut-off value of ≥4 (AUC = 0.816). Conclusion: The number of 18F-FDG avid peritoneal sites increased the risk of incomplete tumor debulking after surgery and potentially useful in assisting treatment stratification in patients with ovarian and peritoneal cancers.
Persistent Identifierhttp://hdl.handle.net/10722/285278
ISSN
2018 Impact Factor: 2.469
2015 SCImago Journal Rankings: 1.085
PubMed Central ID
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorTSOI, TT-
dc.contributor.authorChiu, WHK-
dc.contributor.authorChu, MY-
dc.contributor.authorNgan, HYS-
dc.contributor.authorLee, EYP-
dc.date.accessioned2020-08-18T03:51:57Z-
dc.date.available2020-08-18T03:51:57Z-
dc.date.issued2020-
dc.identifier.citationJournal of Ovarian Research, 2020, v. 13 n. 1, p. article no. 61-
dc.identifier.issn1757-2215-
dc.identifier.urihttp://hdl.handle.net/10722/285278-
dc.description.abstractRationale and objectives: To evaluate the impact of metabolic parameters in the peritoneal cavity on the likelihood of achieving complete tumor debulking in patients with ovarian and peritoneal cancers. Materials and methods: Forty-nine patients with ovarian and peritoneal cancers were included, who underwent pre-operative 18F-fluorodeoxyglucose Positron Emission Tomography/Computed Tomography (18F-FDG PET/CT). The immediate surgical outcome was dichotomized into complete and incomplete tumor debulking. 18F-FDG PET/CT was qualitatively and quantitatively assessed by scrutinizing 15 anatomical sites for the presence of peritoneal carcinomatosis (PC). Patient-based and site-based diagnostic characteristics were described. Metabolic parameters (SUVmax, metabolic tumor volume and total lesion glycolysis) and the number of 18F-FDG avid peritoneal sites were evaluated between the two groups. Receiver operating curve (ROC) analysis was performed to determine the optimal cut-off value in predicting incomplete tumor debulking. Results: Twenty-seven out of the 49 patients had PC and 11 had incomplete debulking. Patient-based and site-based accuracies for detection of PC were 87.8 and 97.6%, respectively. The number of 18F-FDG avid peritoneal sites was significantly different between complete and incomplete debulking groups (0.6 ± 0.8 versus 2.3 ± 1.7 sites respectively, p = 0.001), and the only independent significant risk factor among other metabolic parameters tested (odd ratio = 2.983, 95% CI 1.104–8.062) for incomplete tumor debulking with an optimal cut-off value of ≥4 (AUC = 0.816). Conclusion: The number of 18F-FDG avid peritoneal sites increased the risk of incomplete tumor debulking after surgery and potentially useful in assisting treatment stratification in patients with ovarian and peritoneal cancers.-
dc.languageeng-
dc.publisherBioMed Central Ltd. The Journal's web site is located at https://ovarianresearch.biomedcentral.com/-
dc.relation.ispartofJournal of Ovarian Research-
dc.rightsJournal of Ovarian Research. Copyright © BioMed Central Ltd.-
dc.rightsThis work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.-
dc.subject18F-FDG PET/CT-
dc.subjectOvarian and peritoneal cancers-
dc.subjectTumor debulking-
dc.subjectPeritoneal carcinomatosis-
dc.titleMetabolic active peritoneal sites affect tumor debulking in ovarian and peritoneal cancers-
dc.typeArticle-
dc.identifier.emailChiu, WHK: kwhchiu@hku.hk-
dc.identifier.emailChu, MY: chumy@hku.hk-
dc.identifier.emailNgan, HYS: hysngan@hkucc.hku.hk-
dc.identifier.emailLee, EYP: eyplee77@hku.hk-
dc.identifier.authorityChiu, WHK=rp02074-
dc.identifier.authorityNgan, HYS=rp00346-
dc.identifier.authorityLee, EYP=rp01456-
dc.description.naturepublished_or_final_version-
dc.identifier.doi10.1186/s13048-020-00662-3-
dc.identifier.pmid32434520-
dc.identifier.pmcidPMC7238625-
dc.identifier.scopuseid_2-s2.0-85085154881-
dc.identifier.hkuros312775-
dc.identifier.volume13-
dc.identifier.issue1-
dc.identifier.spagearticle no. 61-
dc.identifier.epagearticle no. 61-
dc.identifier.isiWOS:000536812400001-
dc.publisher.placeUnited Kingdom-
dc.identifier.issnl1757-2215-

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