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Article: Metabolic active peritoneal sites affect tumor debulking in ovarian and peritoneal cancers
Title | Metabolic active peritoneal sites affect tumor debulking in ovarian and peritoneal cancers |
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Authors | |
Keywords | 18F-FDG PET/CT Ovarian and peritoneal cancers Tumor debulking Peritoneal carcinomatosis |
Issue Date | 2020 |
Publisher | BioMed Central Ltd. The Journal's web site is located at https://ovarianresearch.biomedcentral.com/ |
Citation | Journal of Ovarian Research, 2020, v. 13 n. 1, p. article no. 61 How to Cite? |
Abstract | Rationale and objectives:
To evaluate the impact of metabolic parameters in the peritoneal cavity on the likelihood of achieving complete tumor debulking in patients with ovarian and peritoneal cancers.
Materials and methods:
Forty-nine patients with ovarian and peritoneal cancers were included, who underwent pre-operative 18F-fluorodeoxyglucose Positron Emission Tomography/Computed Tomography (18F-FDG PET/CT). The immediate surgical outcome was dichotomized into complete and incomplete tumor debulking. 18F-FDG PET/CT was qualitatively and quantitatively assessed by scrutinizing 15 anatomical sites for the presence of peritoneal carcinomatosis (PC). Patient-based and site-based diagnostic characteristics were described. Metabolic parameters (SUVmax, metabolic tumor volume and total lesion glycolysis) and the number of 18F-FDG avid peritoneal sites were evaluated between the two groups. Receiver operating curve (ROC) analysis was performed to determine the optimal cut-off value in predicting incomplete tumor debulking.
Results:
Twenty-seven out of the 49 patients had PC and 11 had incomplete debulking. Patient-based and site-based accuracies for detection of PC were 87.8 and 97.6%, respectively. The number of 18F-FDG avid peritoneal sites was significantly different between complete and incomplete debulking groups (0.6 ± 0.8 versus 2.3 ± 1.7 sites respectively, p = 0.001), and the only independent significant risk factor among other metabolic parameters tested (odd ratio = 2.983, 95% CI 1.104–8.062) for incomplete tumor debulking with an optimal cut-off value of ≥4 (AUC = 0.816).
Conclusion:
The number of 18F-FDG avid peritoneal sites increased the risk of incomplete tumor debulking after surgery and potentially useful in assisting treatment stratification in patients with ovarian and peritoneal cancers. |
Persistent Identifier | http://hdl.handle.net/10722/285278 |
ISSN | 2021 Impact Factor: 5.506 2020 SCImago Journal Rankings: 1.154 |
PubMed Central ID | |
ISI Accession Number ID |
DC Field | Value | Language |
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dc.contributor.author | TSOI, TT | - |
dc.contributor.author | Chiu, WHK | - |
dc.contributor.author | Chu, MY | - |
dc.contributor.author | Ngan, HYS | - |
dc.contributor.author | Lee, EYP | - |
dc.date.accessioned | 2020-08-18T03:51:57Z | - |
dc.date.available | 2020-08-18T03:51:57Z | - |
dc.date.issued | 2020 | - |
dc.identifier.citation | Journal of Ovarian Research, 2020, v. 13 n. 1, p. article no. 61 | - |
dc.identifier.issn | 1757-2215 | - |
dc.identifier.uri | http://hdl.handle.net/10722/285278 | - |
dc.description.abstract | Rationale and objectives: To evaluate the impact of metabolic parameters in the peritoneal cavity on the likelihood of achieving complete tumor debulking in patients with ovarian and peritoneal cancers. Materials and methods: Forty-nine patients with ovarian and peritoneal cancers were included, who underwent pre-operative 18F-fluorodeoxyglucose Positron Emission Tomography/Computed Tomography (18F-FDG PET/CT). The immediate surgical outcome was dichotomized into complete and incomplete tumor debulking. 18F-FDG PET/CT was qualitatively and quantitatively assessed by scrutinizing 15 anatomical sites for the presence of peritoneal carcinomatosis (PC). Patient-based and site-based diagnostic characteristics were described. Metabolic parameters (SUVmax, metabolic tumor volume and total lesion glycolysis) and the number of 18F-FDG avid peritoneal sites were evaluated between the two groups. Receiver operating curve (ROC) analysis was performed to determine the optimal cut-off value in predicting incomplete tumor debulking. Results: Twenty-seven out of the 49 patients had PC and 11 had incomplete debulking. Patient-based and site-based accuracies for detection of PC were 87.8 and 97.6%, respectively. The number of 18F-FDG avid peritoneal sites was significantly different between complete and incomplete debulking groups (0.6 ± 0.8 versus 2.3 ± 1.7 sites respectively, p = 0.001), and the only independent significant risk factor among other metabolic parameters tested (odd ratio = 2.983, 95% CI 1.104–8.062) for incomplete tumor debulking with an optimal cut-off value of ≥4 (AUC = 0.816). Conclusion: The number of 18F-FDG avid peritoneal sites increased the risk of incomplete tumor debulking after surgery and potentially useful in assisting treatment stratification in patients with ovarian and peritoneal cancers. | - |
dc.language | eng | - |
dc.publisher | BioMed Central Ltd. The Journal's web site is located at https://ovarianresearch.biomedcentral.com/ | - |
dc.relation.ispartof | Journal of Ovarian Research | - |
dc.rights | Journal of Ovarian Research. Copyright © BioMed Central Ltd. | - |
dc.rights | This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License. | - |
dc.subject | 18F-FDG PET/CT | - |
dc.subject | Ovarian and peritoneal cancers | - |
dc.subject | Tumor debulking | - |
dc.subject | Peritoneal carcinomatosis | - |
dc.title | Metabolic active peritoneal sites affect tumor debulking in ovarian and peritoneal cancers | - |
dc.type | Article | - |
dc.identifier.email | Chiu, WHK: kwhchiu@hku.hk | - |
dc.identifier.email | Chu, MY: chumy@hku.hk | - |
dc.identifier.email | Ngan, HYS: hysngan@hkucc.hku.hk | - |
dc.identifier.email | Lee, EYP: eyplee77@hku.hk | - |
dc.identifier.authority | Chiu, WHK=rp02074 | - |
dc.identifier.authority | Ngan, HYS=rp00346 | - |
dc.identifier.authority | Lee, EYP=rp01456 | - |
dc.description.nature | published_or_final_version | - |
dc.identifier.doi | 10.1186/s13048-020-00662-3 | - |
dc.identifier.pmid | 32434520 | - |
dc.identifier.pmcid | PMC7238625 | - |
dc.identifier.scopus | eid_2-s2.0-85085154881 | - |
dc.identifier.hkuros | 312775 | - |
dc.identifier.volume | 13 | - |
dc.identifier.issue | 1 | - |
dc.identifier.spage | article no. 61 | - |
dc.identifier.epage | article no. 61 | - |
dc.identifier.isi | WOS:000536812400001 | - |
dc.publisher.place | United Kingdom | - |
dc.identifier.issnl | 1757-2215 | - |