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Article: B-Value Optimization in the Estimation of Intravoxel Incoherent Motion Parameters in Patients with Cervical Cancer

TitleB-Value Optimization in the Estimation of Intravoxel Incoherent Motion Parameters in Patients with Cervical Cancer
Authors
KeywordsCervical cancer
Magnetic resonance imaging
Diffusion-weighted imaging
Intravoxel incoherent motion
b-values
Issue Date2020
PublisherKorean Society of Radiology. The Journal's web site is located at http://www.kjronline.org/
Citation
Korean Journal of Radiology, 2020, v. 21 n. 2, p. 218-227 How to Cite?
AbstractObjective: This study aimed to find the optimal number of b-values for intravoxel incoherent motion (IVIM) imaging analysis, using simulated and in vivo data from cervical cancer patients. Materials and Methods: Simulated data were generated using literature pooled means, which served as reference values for simulations. In vivo data from 100 treatment-naïve cervical cancer patients with IVIM imaging (13 b-values, scan time, 436 seconds) were retrospectively reviewed. A stepwise b-value fitting algorithm calculated optimal thresholds. Feed forward selection determined the optimal subsampled b-value distribution for biexponential IVIM fitting, and simplified IVIM modeling using monoexponential fitting was attempted. IVIM parameters computed using all b-values served as reference values for in vivo data. Results: In simulations, parameters were accurately estimated with six b-values, or three b-values for simplified IVIM, respectively. In vivo data showed that the optimal threshold was 40 s/mm2 for patients with squamous cell carcinoma and a subsampled acquisition of six b-values (scan time, 198 seconds) estimated parameters were not significantly different from reference parameters (individual parameter error rates of less than 5%). In patients with adenocarcinoma, the optimal threshold was 100 s/mm2, but an optimal subsample could not be identified. Irrespective of the histological subtype, only three b-values were needed for simplified IVIM, but these parameters did not retain their discriminative ability. Conclusion: Subsampling of six b-values halved the IVIM scan time without significant losses in accuracy and discriminative ability. Simplified IVIM is possible with only three b-values, at the risk of losing diagnostic information.
Persistent Identifierhttp://hdl.handle.net/10722/285469
ISSN
2023 Impact Factor: 4.4
2023 SCImago Journal Rankings: 1.235
PubMed Central ID
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorPERUCHO, JAU-
dc.contributor.authorChang, HCC-
dc.contributor.authorVardhanabhuti, V-
dc.contributor.authorWANG, M-
dc.contributor.authorBecker, AS-
dc.contributor.authorWurnig, MC-
dc.contributor.authorLee, EYP-
dc.date.accessioned2020-08-18T03:53:43Z-
dc.date.available2020-08-18T03:53:43Z-
dc.date.issued2020-
dc.identifier.citationKorean Journal of Radiology, 2020, v. 21 n. 2, p. 218-227-
dc.identifier.issn1229-6929-
dc.identifier.urihttp://hdl.handle.net/10722/285469-
dc.description.abstractObjective: This study aimed to find the optimal number of b-values for intravoxel incoherent motion (IVIM) imaging analysis, using simulated and in vivo data from cervical cancer patients. Materials and Methods: Simulated data were generated using literature pooled means, which served as reference values for simulations. In vivo data from 100 treatment-naïve cervical cancer patients with IVIM imaging (13 b-values, scan time, 436 seconds) were retrospectively reviewed. A stepwise b-value fitting algorithm calculated optimal thresholds. Feed forward selection determined the optimal subsampled b-value distribution for biexponential IVIM fitting, and simplified IVIM modeling using monoexponential fitting was attempted. IVIM parameters computed using all b-values served as reference values for in vivo data. Results: In simulations, parameters were accurately estimated with six b-values, or three b-values for simplified IVIM, respectively. In vivo data showed that the optimal threshold was 40 s/mm2 for patients with squamous cell carcinoma and a subsampled acquisition of six b-values (scan time, 198 seconds) estimated parameters were not significantly different from reference parameters (individual parameter error rates of less than 5%). In patients with adenocarcinoma, the optimal threshold was 100 s/mm2, but an optimal subsample could not be identified. Irrespective of the histological subtype, only three b-values were needed for simplified IVIM, but these parameters did not retain their discriminative ability. Conclusion: Subsampling of six b-values halved the IVIM scan time without significant losses in accuracy and discriminative ability. Simplified IVIM is possible with only three b-values, at the risk of losing diagnostic information.-
dc.languageeng-
dc.publisherKorean Society of Radiology. The Journal's web site is located at http://www.kjronline.org/-
dc.relation.ispartofKorean Journal of Radiology-
dc.rightsThis work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.-
dc.subjectCervical cancer-
dc.subjectMagnetic resonance imaging-
dc.subjectDiffusion-weighted imaging-
dc.subjectIntravoxel incoherent motion-
dc.subjectb-values-
dc.titleB-Value Optimization in the Estimation of Intravoxel Incoherent Motion Parameters in Patients with Cervical Cancer-
dc.typeArticle-
dc.identifier.emailChang, HCC: hcchang@hku.hk-
dc.identifier.emailVardhanabhuti, V: varv@hku.hk-
dc.identifier.emailLee, EYP: eyplee77@hku.hk-
dc.identifier.authorityChang, HCC=rp02024-
dc.identifier.authorityVardhanabhuti, V=rp01900-
dc.identifier.authorityLee, EYP=rp01456-
dc.description.naturepublished_or_final_version-
dc.identifier.doi10.3348/kjr.2019.0232-
dc.identifier.pmid31997597-
dc.identifier.pmcidPMC6992446-
dc.identifier.scopuseid_2-s2.0-85078690799-
dc.identifier.hkuros312772-
dc.identifier.volume21-
dc.identifier.issue2-
dc.identifier.spage218-
dc.identifier.epage227-
dc.identifier.isiWOS:000523561000011-
dc.publisher.placeRepublic of Korea-
dc.identifier.issnl1229-6929-

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