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- Publisher Website: 10.1186/s12903-020-1038-4
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Article: Remineralising effect of 45S5 bioactive glass on artificial caries in dentine
Title | Remineralising effect of 45S5 bioactive glass on artificial caries in dentine |
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Authors | |
Keywords | Artificial caries Dentine Remineralisation Bioactive glass CPP-ACP |
Issue Date | 2020 |
Publisher | BioMed Central Ltd. The Journal's web site is located at http://www.biomedcentral.com/bmcoralhealth/ |
Citation | BMC Oral Health, 2020, v. 20 n. 1, p. article no. 49 How to Cite? |
Abstract | Background:
This study investigated the remineralisation effect of bioactive glass on artificial dentine caries.
Methods:
Dentine disks with artificial caries were treated with bioactive glass (group BAG), casein phosphopeptide–amorphous calcium phosphate (CPP-ACP) (group CPP-ACP), sodium fluoride glycerol (group F) or deionized water (group W). All disks were subjected to pH cycling for 28 days subsequently. The topography, microhardness and remineralisation depth of the dentine carious lesion were assessed by atomic force microscopy (AFM), microhardness testing and confocal laser scanning microscope (CLSM), respectively.
Results:
AFM images indicated mineral depositions on the surface of the carious lesion in group BAG. The changes of Vickers hardness number (ΔVHN, mean ± SD) after pH cycling were 9.67 ± 3.60, 6.06 ± 3.83, 5.00 ± 2.19 and − 1.90 ± 2.09 (p < 0.001) in group BAG, group CPP-ACP, group F and group W, respectively. The remineralisation depth (mean ± SD) of the carious lesion in group BAG, group CPP-ACP, group F and group W were 165 ± 11 μm, 111 ± 11 μm, 75 ± 6 μm and 0 μm (p < 0.001), respectively.
Conclusion:
Bioactive glass possessed a promising remineralisation effect on artificial dentine caries and could be a therapeutic choice for caries management. |
Persistent Identifier | http://hdl.handle.net/10722/288031 |
ISSN | 2021 Impact Factor: 3.747 2020 SCImago Journal Rankings: 0.868 |
PubMed Central ID | |
ISI Accession Number ID |
DC Field | Value | Language |
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dc.contributor.author | Wu, Q | - |
dc.contributor.author | Mei, ML | - |
dc.contributor.author | Wu, X | - |
dc.contributor.author | Shi, S | - |
dc.contributor.author | Xu, Y | - |
dc.contributor.author | Chu, CH | - |
dc.contributor.author | Chen, Y | - |
dc.date.accessioned | 2020-10-05T12:06:51Z | - |
dc.date.available | 2020-10-05T12:06:51Z | - |
dc.date.issued | 2020 | - |
dc.identifier.citation | BMC Oral Health, 2020, v. 20 n. 1, p. article no. 49 | - |
dc.identifier.issn | 1472-6831 | - |
dc.identifier.uri | http://hdl.handle.net/10722/288031 | - |
dc.description.abstract | Background: This study investigated the remineralisation effect of bioactive glass on artificial dentine caries. Methods: Dentine disks with artificial caries were treated with bioactive glass (group BAG), casein phosphopeptide–amorphous calcium phosphate (CPP-ACP) (group CPP-ACP), sodium fluoride glycerol (group F) or deionized water (group W). All disks were subjected to pH cycling for 28 days subsequently. The topography, microhardness and remineralisation depth of the dentine carious lesion were assessed by atomic force microscopy (AFM), microhardness testing and confocal laser scanning microscope (CLSM), respectively. Results: AFM images indicated mineral depositions on the surface of the carious lesion in group BAG. The changes of Vickers hardness number (ΔVHN, mean ± SD) after pH cycling were 9.67 ± 3.60, 6.06 ± 3.83, 5.00 ± 2.19 and − 1.90 ± 2.09 (p < 0.001) in group BAG, group CPP-ACP, group F and group W, respectively. The remineralisation depth (mean ± SD) of the carious lesion in group BAG, group CPP-ACP, group F and group W were 165 ± 11 μm, 111 ± 11 μm, 75 ± 6 μm and 0 μm (p < 0.001), respectively. Conclusion: Bioactive glass possessed a promising remineralisation effect on artificial dentine caries and could be a therapeutic choice for caries management. | - |
dc.language | eng | - |
dc.publisher | BioMed Central Ltd. The Journal's web site is located at http://www.biomedcentral.com/bmcoralhealth/ | - |
dc.relation.ispartof | BMC Oral Health | - |
dc.rights | BMC Oral Health. Copyright © BioMed Central Ltd. | - |
dc.rights | This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License. | - |
dc.subject | Artificial caries | - |
dc.subject | Dentine | - |
dc.subject | Remineralisation | - |
dc.subject | Bioactive glass | - |
dc.subject | CPP-ACP | - |
dc.title | Remineralising effect of 45S5 bioactive glass on artificial caries in dentine | - |
dc.type | Article | - |
dc.identifier.email | Chu, CH: chchu@hku.hk | - |
dc.identifier.authority | Chu, CH=rp00022 | - |
dc.description.nature | published_or_final_version | - |
dc.identifier.doi | 10.1186/s12903-020-1038-4 | - |
dc.identifier.pmid | 32046691 | - |
dc.identifier.pmcid | PMC7014937 | - |
dc.identifier.scopus | eid_2-s2.0-85079335787 | - |
dc.identifier.hkuros | 315782 | - |
dc.identifier.volume | 20 | - |
dc.identifier.issue | 1 | - |
dc.identifier.spage | article no. 49 | - |
dc.identifier.epage | article no. 49 | - |
dc.identifier.isi | WOS:000514406200001 | - |
dc.publisher.place | United Kingdom | - |
dc.identifier.issnl | 1472-6831 | - |