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Article: Randomized clinical trial on sodium fluoride with tricalcium phosphate

TitleRandomized clinical trial on sodium fluoride with tricalcium phosphate
Authors
Keywordschild
dental care
dental caries
dentin
silver
Issue Date2020
PublisherSage Publications, Inc. The Journal's web site is located at http://jdr.sagepub.com/
Citation
Journal of Dental Research, 2020, v. 100 n. 1, p. 66-73 How to Cite?
AbstractThis 24-mo randomized controlled trial was based on a double-blind parallel design, and it compared the effectiveness of 2 fluoride application protocols in arresting dentine caries in primary teeth. Three-year-old children with active dentine caries were recruited and randomly allocated to 2 treatment groups. Children in group A received a semiannual application of a 25% silver nitrate (AgNO3) solution followed by a commercially available varnish with 5% sodium fluoride (NaF) on the carious tooth surfaces. Children in group B received a semiannual application of a 25% AgNO3 solution followed by another commercially available varnish with 5% NaF containing functionalized tricalcium phosphate (fTCP). Carious tooth surfaces that were hard when probing were classified as arrested. Intention-to-treat analysis and a hierarchical generalized linear model were undertaken. A total of 408 children with 1,831 tooth surfaces with active dentine caries were recruited at baseline, and 356 children (87%) with 1,607 tooth surfaces (88%) were assessed after 24 mo. At the 24-mo evaluation, the mean (SD) number of arrested carious tooth surfaces per child were 1.8 (2.2) and 2.6 (3.3) for group A (without fTCP) and group B (with fTCP), respectively (P = 0.003). The arrest rates at the tooth surface level were 42% for group A and 57% for group B (P < 0.001). Results of the hierarchical generalized linear model indicated that protocol B (with fTCP) had a higher predicted probability (PP = 0.656) in arresting dentine caries than protocol A (without fTCP; PP = 0.500) when the carious lesions were on buccal/lingual surfaces, were on anterior teeth, had dental plaque coverage, and were in children from low-income families (P = 0.046). In conclusion, protocol B, which applied a 25% AgNO3 solution followed by a commercially available 5% NaF varnish with fTCP semiannually, is more effective in arresting dentine caries in primary teeth as compared with protocol A, which applied a 25% AgNO3 solution followed by another commercially available 5% NaF varnish without fTCP semiannually (ClinicalTrials.gov NCT03423797).
Persistent Identifierhttp://hdl.handle.net/10722/288444
ISSN
2023 Impact Factor: 5.7
2023 SCImago Journal Rankings: 1.909
PubMed Central ID
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorChen, KJ-
dc.contributor.authorGao, S-
dc.contributor.authorDuangthip, D-
dc.contributor.authorLo, ECM-
dc.contributor.authorChu, CH-
dc.date.accessioned2020-10-05T12:13:01Z-
dc.date.available2020-10-05T12:13:01Z-
dc.date.issued2020-
dc.identifier.citationJournal of Dental Research, 2020, v. 100 n. 1, p. 66-73-
dc.identifier.issn0022-0345-
dc.identifier.urihttp://hdl.handle.net/10722/288444-
dc.description.abstractThis 24-mo randomized controlled trial was based on a double-blind parallel design, and it compared the effectiveness of 2 fluoride application protocols in arresting dentine caries in primary teeth. Three-year-old children with active dentine caries were recruited and randomly allocated to 2 treatment groups. Children in group A received a semiannual application of a 25% silver nitrate (AgNO3) solution followed by a commercially available varnish with 5% sodium fluoride (NaF) on the carious tooth surfaces. Children in group B received a semiannual application of a 25% AgNO3 solution followed by another commercially available varnish with 5% NaF containing functionalized tricalcium phosphate (fTCP). Carious tooth surfaces that were hard when probing were classified as arrested. Intention-to-treat analysis and a hierarchical generalized linear model were undertaken. A total of 408 children with 1,831 tooth surfaces with active dentine caries were recruited at baseline, and 356 children (87%) with 1,607 tooth surfaces (88%) were assessed after 24 mo. At the 24-mo evaluation, the mean (SD) number of arrested carious tooth surfaces per child were 1.8 (2.2) and 2.6 (3.3) for group A (without fTCP) and group B (with fTCP), respectively (P = 0.003). The arrest rates at the tooth surface level were 42% for group A and 57% for group B (P < 0.001). Results of the hierarchical generalized linear model indicated that protocol B (with fTCP) had a higher predicted probability (PP = 0.656) in arresting dentine caries than protocol A (without fTCP; PP = 0.500) when the carious lesions were on buccal/lingual surfaces, were on anterior teeth, had dental plaque coverage, and were in children from low-income families (P = 0.046). In conclusion, protocol B, which applied a 25% AgNO3 solution followed by a commercially available 5% NaF varnish with fTCP semiannually, is more effective in arresting dentine caries in primary teeth as compared with protocol A, which applied a 25% AgNO3 solution followed by another commercially available 5% NaF varnish without fTCP semiannually (ClinicalTrials.gov NCT03423797).-
dc.languageeng-
dc.publisherSage Publications, Inc. The Journal's web site is located at http://jdr.sagepub.com/-
dc.relation.ispartofJournal of Dental Research-
dc.rightsK.J. Chen, S.S. Gao, D. Duangthip, E.C.M. Lo, C.H. Chu, Randomized Clinical Trial on Sodium Fluoride with Tricalcium Phosphate, Journal of Dental Research, 2020, v. 100 n. 1, p. 66-73. Copyright © [2020] (Copyright International & American Associations for Dental Research). DOI: [10.1177/0022034520952031].-
dc.rightsThis work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.-
dc.subjectchild-
dc.subjectdental care-
dc.subjectdental caries-
dc.subjectdentin-
dc.subjectsilver-
dc.titleRandomized clinical trial on sodium fluoride with tricalcium phosphate-
dc.typeArticle-
dc.identifier.emailGao, S: sherryg@hku.hk-
dc.identifier.emailDuangthip, D: dduang@hku.hk-
dc.identifier.emailLo, ECM: edward-lo@hku.hk-
dc.identifier.emailChu, CH: chchu@hku.hk-
dc.identifier.authorityGao, S=rp02662-
dc.identifier.authorityDuangthip, D=rp02457-
dc.identifier.authorityLo, ECM=rp00015-
dc.identifier.authorityChu, CH=rp00022-
dc.description.naturepublished_or_final_version-
dc.identifier.doi10.1177/0022034520952031-
dc.identifier.pmid32866050-
dc.identifier.pmcidPMC7754823-
dc.identifier.scopuseid_2-s2.0-85090061131-
dc.identifier.hkuros315801-
dc.identifier.volume100-
dc.identifier.issue1-
dc.identifier.spage66-
dc.identifier.epage73-
dc.identifier.eissn1544-0591-
dc.identifier.isiWOS:000564857100001-
dc.publisher.placeUnited States-
dc.identifier.issnl0022-0345-

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