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- Publisher Website: 10.1210/clinem/dgaa555
- Scopus: eid_2-s2.0-85092332251
- PMID: 32810262
- WOS: WOS:000584547800019
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Article: Maternal Thyroid Dysfunction During Pregnancy and the Risk of Adverse Outcomes in the Offspring: A Systematic Review and Meta-Analysis
Title | Maternal Thyroid Dysfunction During Pregnancy and the Risk of Adverse Outcomes in the Offspring: A Systematic Review and Meta-Analysis |
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Authors | |
Keywords | gestation child development offspring pregnancy thyroid |
Issue Date | 2020 |
Publisher | Oxford University Press. The Journal's web site is located at https://academic.oup.com/jcem |
Citation | The Journal of Clinical Endocrinology & Metabolism, 2020, v. 105 n. 12, p. 3821-3841 How to Cite? |
Abstract | Context:
Previous studies suggested a potential link of maternal thyroid dysfunction with adverse neurocognitive outcomes and impaired development of internal organs in offspring.
Objective:
To review the association between maternal thyroid dysfunction and the risk of adverse outcomes in offspring.
Data Sources:
PubMed, EMBASE, and Cochrane Library.
Study Selections:
Eligible studies reported the association between maternal thyroid hormone function and the risk of adverse outcomes in their children.
Data Extraction:
Reviewers extracted data on study characteristics and results independently.
Data Synthesis:
Estimates were pooled and reported as odds ratio (OR) with 95% confidence interval (CI). I2 tests were applied to assess the heterogeneity across studies.
Results:
We identified 29 eligible articles and found an association between maternal hyperthyroidism and attention deficit hyperactivity disorder (ADHD) (OR: 1.18, 95% CI: 1.04-1.34, I2 = 0%) and epilepsy (OR: 1.19, 95% CI: 1.08-1.31, I2 = 0%) in offspring; as well as an association of maternal hypothyroidism with increased risk of ADHD (OR: 1.14, 95% CI: 1.03-1.26, I2 = 25%), autism spectrum disorder (OR: 1.41, 95% CI: 1.05-1.90, I2 = 63%), and epilepsy (OR: 1.21, 95% CI: 1.06-1.39, I2 = 0%) in offspring.
Conclusion:
Routine measurement and timely treatment on thyroid function should be considered for pregnant women. |
Persistent Identifier | http://hdl.handle.net/10722/289379 |
ISSN | 2023 Impact Factor: 5.0 2023 SCImago Journal Rankings: 1.899 |
ISI Accession Number ID |
DC Field | Value | Language |
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dc.contributor.author | Ge, GM | - |
dc.contributor.author | Leung, MTY | - |
dc.contributor.author | Man, KKC | - |
dc.contributor.author | Leung, WC | - |
dc.contributor.author | Ip, P | - |
dc.contributor.author | Li, GHY | - |
dc.contributor.author | Wong, ICK | - |
dc.contributor.author | Kung, AWC | - |
dc.contributor.author | Cheung, CL | - |
dc.date.accessioned | 2020-10-22T08:11:48Z | - |
dc.date.available | 2020-10-22T08:11:48Z | - |
dc.date.issued | 2020 | - |
dc.identifier.citation | The Journal of Clinical Endocrinology & Metabolism, 2020, v. 105 n. 12, p. 3821-3841 | - |
dc.identifier.issn | 0021-972X | - |
dc.identifier.uri | http://hdl.handle.net/10722/289379 | - |
dc.description.abstract | Context: Previous studies suggested a potential link of maternal thyroid dysfunction with adverse neurocognitive outcomes and impaired development of internal organs in offspring. Objective: To review the association between maternal thyroid dysfunction and the risk of adverse outcomes in offspring. Data Sources: PubMed, EMBASE, and Cochrane Library. Study Selections: Eligible studies reported the association between maternal thyroid hormone function and the risk of adverse outcomes in their children. Data Extraction: Reviewers extracted data on study characteristics and results independently. Data Synthesis: Estimates were pooled and reported as odds ratio (OR) with 95% confidence interval (CI). I2 tests were applied to assess the heterogeneity across studies. Results: We identified 29 eligible articles and found an association between maternal hyperthyroidism and attention deficit hyperactivity disorder (ADHD) (OR: 1.18, 95% CI: 1.04-1.34, I2 = 0%) and epilepsy (OR: 1.19, 95% CI: 1.08-1.31, I2 = 0%) in offspring; as well as an association of maternal hypothyroidism with increased risk of ADHD (OR: 1.14, 95% CI: 1.03-1.26, I2 = 25%), autism spectrum disorder (OR: 1.41, 95% CI: 1.05-1.90, I2 = 63%), and epilepsy (OR: 1.21, 95% CI: 1.06-1.39, I2 = 0%) in offspring. Conclusion: Routine measurement and timely treatment on thyroid function should be considered for pregnant women. | - |
dc.language | eng | - |
dc.publisher | Oxford University Press. The Journal's web site is located at https://academic.oup.com/jcem | - |
dc.relation.ispartof | The Journal of Clinical Endocrinology & Metabolism | - |
dc.rights | Pre-print: Journal Title] ©: [year] [owner as specified on the article] Published by Oxford University Press [on behalf of xxxxxx]. All rights reserved. Pre-print (Once an article is published, preprint notice should be amended to): This is an electronic version of an article published in [include the complete citation information for the final version of the Article as published in the print edition of the Journal.] Post-print: This is a pre-copy-editing, author-produced PDF of an article accepted for publication in [insert journal title] following peer review. The definitive publisher-authenticated version [insert complete citation information here] is available online at: xxxxxxx [insert URL that the author will receive upon publication here]. | - |
dc.subject | gestation | - |
dc.subject | child development | - |
dc.subject | offspring | - |
dc.subject | pregnancy | - |
dc.subject | thyroid | - |
dc.title | Maternal Thyroid Dysfunction During Pregnancy and the Risk of Adverse Outcomes in the Offspring: A Systematic Review and Meta-Analysis | - |
dc.type | Article | - |
dc.identifier.email | Leung, MTY: mleungty@hku.hk | - |
dc.identifier.email | Man, KKC: mkckth@hku.hk | - |
dc.identifier.email | Ip, P: patricip@hku.hk | - |
dc.identifier.email | Li, GHY: gloriali@hku.hk | - |
dc.identifier.email | Wong, ICK: wongick@hku.hk | - |
dc.identifier.email | Kung, AWC: awckung@hku.hk | - |
dc.identifier.email | Cheung, CL: lung1212@hku.hk | - |
dc.identifier.authority | Ip, P=rp01337 | - |
dc.identifier.authority | Wong, ICK=rp01480 | - |
dc.identifier.authority | Kung, AWC=rp00368 | - |
dc.identifier.authority | Cheung, CL=rp01749 | - |
dc.description.nature | link_to_subscribed_fulltext | - |
dc.identifier.doi | 10.1210/clinem/dgaa555 | - |
dc.identifier.pmid | 32810262 | - |
dc.identifier.scopus | eid_2-s2.0-85092332251 | - |
dc.identifier.hkuros | 316026 | - |
dc.identifier.volume | 105 | - |
dc.identifier.issue | 12 | - |
dc.identifier.spage | 3821 | - |
dc.identifier.epage | 3841 | - |
dc.identifier.isi | WOS:000584547800019 | - |
dc.publisher.place | United States | - |
dc.identifier.issnl | 0021-972X | - |