File Download

There are no files associated with this item.

  Links for fulltext
     (May Require Subscription)

Article: Electroacupuncture trigeminal nerve stimulation plus body acupuncture for chemotherapy-induced cognitive impairment in breast cancer patients: An assessor-participant blinded, randomized controlled trial

TitleElectroacupuncture trigeminal nerve stimulation plus body acupuncture for chemotherapy-induced cognitive impairment in breast cancer patients: An assessor-participant blinded, randomized controlled trial
Authors
KeywordsTrigeminal nerve stimulation
Acupuncture
Chemotherapy
Mild cognitive impairment
Chemobrain
Issue Date2020
PublisherAcademic Press. The Journal's web site is located at http://www.elsevier.com/locate/ybrbi
Citation
Brain, Behavior, and Immunity, 2020, v. 88, p. 88-96 How to Cite?
AbstractChemotherapy causes various side effects, including cognitive impairment, known as ‘chemobrain’. In this study, we determined whether a novel acupuncture mode called electroacupuncture trigeminal nerve stimulation plus body acupuncture (EA/TNS + BA) could produce better outcomes than minimum acupuncture stimulation (MAS) as controls in treating chemobrain and other symptoms in breast cancer patients. In this assessor- and participant-blinded, randomized controlled trial, 93 breast cancer patients under or post chemotherapy were randomly assigned to EA/TNS + BA (n = 46) and MAS (n = 47) for 2 sessions per week over 8 weeks. The Montreal Cognitive Assessment (MoCA) served as the primary outcome. Digit span test was the secondary outcomes for attentional function and working memory. The quality of life and multiple functional assessments were also evaluated. EA/TNS + BA treated group had much better performance than MAS-treated group on reverse digit span test at Week 2 and Week 8, with medium effect sizes of 0.53 and 0.48, respectively, although no significant differences were observed in MoCA score and prevalence of chemobrain between the two groups. EA/TNS + BA also markedly reduced incidences of diarrhoea, poor appetite, headache, anxiety, and irritation, and improved social/family and emotional wellbeing compared to MAS. These results suggest that EA/TNS + BA may have particular benefits in reducing chemotherapy-induced working memory impairment and the incidence of certain digestive, neurological, and distress-related symptoms. It could serve as an effective intervention for breast cancer patients under and post chemotherapy (trial registration: https://www.clinicaltrials.gov: NCT02457039).
Persistent Identifierhttp://hdl.handle.net/10722/294010
ISSN
2020 Impact Factor: 7.217
2015 SCImago Journal Rankings: 2.884
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorZhang, ZJ-
dc.contributor.authorMan, SC-
dc.contributor.authorYam, LL-
dc.contributor.authorYiu, CY-
dc.contributor.authorLeung, RCY-
dc.contributor.authorQIN, ZS-
dc.contributor.authorChan, KW-
dc.contributor.authorLee, VHF-
dc.contributor.authorKwong, A-
dc.contributor.authorYeung, WF-
dc.contributor.authorSo, WKW-
dc.contributor.authorHo, LM-
dc.contributor.authorDong, YY-
dc.date.accessioned2020-11-23T08:25:04Z-
dc.date.available2020-11-23T08:25:04Z-
dc.date.issued2020-
dc.identifier.citationBrain, Behavior, and Immunity, 2020, v. 88, p. 88-96-
dc.identifier.issn0889-1591-
dc.identifier.urihttp://hdl.handle.net/10722/294010-
dc.description.abstractChemotherapy causes various side effects, including cognitive impairment, known as ‘chemobrain’. In this study, we determined whether a novel acupuncture mode called electroacupuncture trigeminal nerve stimulation plus body acupuncture (EA/TNS + BA) could produce better outcomes than minimum acupuncture stimulation (MAS) as controls in treating chemobrain and other symptoms in breast cancer patients. In this assessor- and participant-blinded, randomized controlled trial, 93 breast cancer patients under or post chemotherapy were randomly assigned to EA/TNS + BA (n = 46) and MAS (n = 47) for 2 sessions per week over 8 weeks. The Montreal Cognitive Assessment (MoCA) served as the primary outcome. Digit span test was the secondary outcomes for attentional function and working memory. The quality of life and multiple functional assessments were also evaluated. EA/TNS + BA treated group had much better performance than MAS-treated group on reverse digit span test at Week 2 and Week 8, with medium effect sizes of 0.53 and 0.48, respectively, although no significant differences were observed in MoCA score and prevalence of chemobrain between the two groups. EA/TNS + BA also markedly reduced incidences of diarrhoea, poor appetite, headache, anxiety, and irritation, and improved social/family and emotional wellbeing compared to MAS. These results suggest that EA/TNS + BA may have particular benefits in reducing chemotherapy-induced working memory impairment and the incidence of certain digestive, neurological, and distress-related symptoms. It could serve as an effective intervention for breast cancer patients under and post chemotherapy (trial registration: https://www.clinicaltrials.gov: NCT02457039).-
dc.languageeng-
dc.publisherAcademic Press. The Journal's web site is located at http://www.elsevier.com/locate/ybrbi-
dc.relation.ispartofBrain, Behavior, and Immunity-
dc.subjectTrigeminal nerve stimulation-
dc.subjectAcupuncture-
dc.subjectChemotherapy-
dc.subjectMild cognitive impairment-
dc.subjectChemobrain-
dc.titleElectroacupuncture trigeminal nerve stimulation plus body acupuncture for chemotherapy-induced cognitive impairment in breast cancer patients: An assessor-participant blinded, randomized controlled trial-
dc.typeArticle-
dc.identifier.emailZhang, ZJ: zhangzj@hkucc.hku.hk-
dc.identifier.emailMan, SC: marksman@hku.hk-
dc.identifier.emailYam, LL: luluyam@hku.hk-
dc.identifier.emailChan, KW: kwsherry@hku.hk-
dc.identifier.emailLee, VHF: vhflee@hku.hk-
dc.identifier.emailKwong, A: avakwong@hku.hk-
dc.identifier.emailHo, LM: lmho@hku.hk-
dc.identifier.authorityZhang, ZJ=rp01297-
dc.identifier.authorityChan, KW=rp00539-
dc.identifier.authorityLee, VHF=rp00264-
dc.identifier.authorityKwong, A=rp01734-
dc.identifier.authorityHo, LM=rp00360-
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1016/j.bbi.2020.04.035-
dc.identifier.pmid32305573-
dc.identifier.scopuseid_2-s2.0-85083528411-
dc.identifier.hkuros319621-
dc.identifier.volume88-
dc.identifier.spage88-
dc.identifier.epage96-
dc.identifier.isiWOS:000555709500020-
dc.publisher.placeUnited States-
dc.identifier.issnl0889-1591-

Export via OAI-PMH Interface in XML Formats


OR


Export to Other Non-XML Formats