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Article: Screening for founder and recurrent BRCA mutations in Hong Kong and US Chinese populations

TitleScreening for founder and recurrent BRCA mutations in Hong Kong and US Chinese populations
Authors
Issue Date2018
PublisherHong Kong Academy of Medicine Press. The Journal's web site is located at http://www.hkmj.org/
Citation
Hong Kong Medical Journal, 2018, v. 24 n. 3, suppl. 3, p. 4-6 How to Cite?
Abstract1. A total of 637 blood samples (441 breast, 155 ovarian, and 41 prostate cancers) were obtained in a local Chinese population. 2. The overall prevalence of BRCA mutation was 8.05% and the pickup rate of the recurrent panel was 3.52%. Nearly half of the mutations were covered by this panel. 3. We identified three BRCA mutations that were seen only in patients with ovarian cancer. 4. Of 79 Chinese breast cancer samples collected from overseas, two recurrent mutations were identified. 5. We compared 84 known mutation cases from overseas (comprising 62 different types of mutations) with our recurrent spectrum. Of which, 15 have been identified in Hong Kong and seven of them were covered in the recurrent panel.
Persistent Identifierhttp://hdl.handle.net/10722/294707
ISSN
2020 Impact Factor: 2.227
2020 SCImago Journal Rankings: 0.357

 

DC FieldValueLanguage
dc.contributor.authorKwong, A-
dc.contributor.authorShin, VY-
dc.contributor.authorMa, ESK-
dc.contributor.authorChan, CTL-
dc.contributor.authorFord, JM-
dc.contributor.authorKurian, AW-
dc.contributor.authorTai, E-
dc.date.accessioned2020-12-08T07:40:43Z-
dc.date.available2020-12-08T07:40:43Z-
dc.date.issued2018-
dc.identifier.citationHong Kong Medical Journal, 2018, v. 24 n. 3, suppl. 3, p. 4-6-
dc.identifier.issn1024-2708-
dc.identifier.urihttp://hdl.handle.net/10722/294707-
dc.description.abstract1. A total of 637 blood samples (441 breast, 155 ovarian, and 41 prostate cancers) were obtained in a local Chinese population. 2. The overall prevalence of BRCA mutation was 8.05% and the pickup rate of the recurrent panel was 3.52%. Nearly half of the mutations were covered by this panel. 3. We identified three BRCA mutations that were seen only in patients with ovarian cancer. 4. Of 79 Chinese breast cancer samples collected from overseas, two recurrent mutations were identified. 5. We compared 84 known mutation cases from overseas (comprising 62 different types of mutations) with our recurrent spectrum. Of which, 15 have been identified in Hong Kong and seven of them were covered in the recurrent panel.-
dc.languageeng-
dc.publisherHong Kong Academy of Medicine Press. The Journal's web site is located at http://www.hkmj.org/-
dc.relation.ispartofHong Kong Medical Journal-
dc.titleScreening for founder and recurrent BRCA mutations in Hong Kong and US Chinese populations-
dc.typeArticle-
dc.identifier.emailKwong, A: avakwong@hku.hk-
dc.identifier.emailShin, VY: vyshin@hku.hk-
dc.identifier.authorityKwong, A=rp01734-
dc.identifier.authorityShin, VY=rp02000-
dc.description.naturelink_to_OA_fulltext-
dc.identifier.pmid29937436-
dc.identifier.scopuseid_2-s2.0-85058545041-
dc.identifier.hkuros320402-
dc.identifier.volume24-
dc.identifier.issue3, suppl. 3-
dc.identifier.spage4-
dc.identifier.epage6-
dc.publisher.placeHong Kong-

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