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Article: Non-transdermal microneedles for advanced drug delivery

TitleNon-transdermal microneedles for advanced drug delivery
Authors
KeywordsBiocompatibility
Implant
Biodegradability
Non-transdermal
Drug delivery
Microneedle
Issue Date2020
Citation
Advanced Drug Delivery Reviews, 2020, v. 165-166, p. 41-59 How to Cite?
AbstractMicroneedles (MNs) have been used to deliver drugs for over two decades. These platforms have been proven to increase transdermal drug delivery efficiency dramatically by penetrating restrictive tissue barriers in a minimally invasive manner. While much of the early development of MNs focused on transdermal drug delivery, this technology can be applied to a variety of other non-transdermal biomedical applications. Several variations, such as multi-layer or hollow MNs, have been developed to cater to the needs of specific applications. The heterogeneity in the design of MNs has demanded similar variety in their fabrication methods; the most common methods include micromolding and drawing lithography. Numerous materials have been explored for MN fabrication which range from biocompatible ceramics and metals to natural and synthetic biodegradable polymers. Recent advances in MN engineering have diversified MNs to include unique shapes, materials, and mechanical properties that can be tailored for organ-specific applications. In this review, we discuss the design and creation of modern MNs that aim to surpass the biological barriers of non-transdermal drug delivery in ocular, vascular, oral, and mucosal tissue.
Persistent Identifierhttp://hdl.handle.net/10722/295417
ISSN
2020 Impact Factor: 15.47
2015 SCImago Journal Rankings: 5.200
PubMed Central ID
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorLee, Kang Ju-
dc.contributor.authorGoudie, Marcus J.-
dc.contributor.authorTebon, Peyton-
dc.contributor.authorSun, Wujin-
dc.contributor.authorLuo, Zhimin-
dc.contributor.authorLee, Junmin-
dc.contributor.authorZhang, Shiming-
dc.contributor.authorFetah, Kirsten-
dc.contributor.authorKim, Han Jun-
dc.contributor.authorXue, Yumeng-
dc.contributor.authorDarabi, Mohammad Ali-
dc.contributor.authorAhadian, Samad-
dc.contributor.authorSarikhani, Einollah-
dc.contributor.authorRyu, Won Hyoung-
dc.contributor.authorGu, Zhen-
dc.contributor.authorWeiss, Paul S.-
dc.contributor.authorDokmeci, Mehmet R.-
dc.contributor.authorAshammakhi, Nureddin-
dc.contributor.authorKhademhosseini, Ali-
dc.date.accessioned2021-01-18T15:46:49Z-
dc.date.available2021-01-18T15:46:49Z-
dc.date.issued2020-
dc.identifier.citationAdvanced Drug Delivery Reviews, 2020, v. 165-166, p. 41-59-
dc.identifier.issn0169-409X-
dc.identifier.urihttp://hdl.handle.net/10722/295417-
dc.description.abstractMicroneedles (MNs) have been used to deliver drugs for over two decades. These platforms have been proven to increase transdermal drug delivery efficiency dramatically by penetrating restrictive tissue barriers in a minimally invasive manner. While much of the early development of MNs focused on transdermal drug delivery, this technology can be applied to a variety of other non-transdermal biomedical applications. Several variations, such as multi-layer or hollow MNs, have been developed to cater to the needs of specific applications. The heterogeneity in the design of MNs has demanded similar variety in their fabrication methods; the most common methods include micromolding and drawing lithography. Numerous materials have been explored for MN fabrication which range from biocompatible ceramics and metals to natural and synthetic biodegradable polymers. Recent advances in MN engineering have diversified MNs to include unique shapes, materials, and mechanical properties that can be tailored for organ-specific applications. In this review, we discuss the design and creation of modern MNs that aim to surpass the biological barriers of non-transdermal drug delivery in ocular, vascular, oral, and mucosal tissue.-
dc.languageeng-
dc.relation.ispartofAdvanced Drug Delivery Reviews-
dc.subjectBiocompatibility-
dc.subjectImplant-
dc.subjectBiodegradability-
dc.subjectNon-transdermal-
dc.subjectDrug delivery-
dc.subjectMicroneedle-
dc.titleNon-transdermal microneedles for advanced drug delivery-
dc.typeArticle-
dc.description.naturelink_to_OA_fulltext-
dc.identifier.doi10.1016/j.addr.2019.11.010-
dc.identifier.pmid31837356-
dc.identifier.pmcidPMC7295684-
dc.identifier.scopuseid_2-s2.0-85076840361-
dc.identifier.volume165-166-
dc.identifier.spage41-
dc.identifier.epage59-
dc.identifier.eissn1872-8294-
dc.identifier.isiWOS:000600556600004-
dc.identifier.issnl0169-409X-

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