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Article: Gelatin Methacryloyl Microneedle Patches for Minimally Invasive Extraction of Skin Interstitial Fluid

TitleGelatin Methacryloyl Microneedle Patches for Minimally Invasive Extraction of Skin Interstitial Fluid
Authors
Keywordsskin interstitial fluid
gelatin methacryloyl
microneedle patches
transdermal extraction
minimally invasive diagnostics
Issue Date2020
Citation
Small, 2020, v. 16, n. 16, article no. 1905910 How to Cite?
Abstract© 2020 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim The extraction of interstitial fluid (ISF) from skin using microneedles (MNs) has attracted growing interest in recent years due to its potential for minimally invasive diagnostics and biosensors. ISF collection by absorption into a hydrogel MN patch is a promising way that requires the materials to have outstanding swelling ability. Here, a gelatin methacryloyl (GelMA) patch is developed with an 11 × 11 array of MNs for minimally invasive sampling of ISF. The properties of the patch can be tuned by altering the concentration of the GelMA prepolymer and the crosslinking time; patches are created with swelling ratios between 293% and 423% and compressive moduli between 3.34 MPa and 7.23 MPa. The optimized GelMA MN patch demonstrates efficient extraction of ISF. Furthermore, it efficiently and quantitatively detects glucose and vancomycin in ISF in an in vivo study. This minimally invasive approach of extracting ISF with a GelMA MN patch has the potential to complement blood sampling for the monitoring of target molecules from patients.
Persistent Identifierhttp://hdl.handle.net/10722/295419
ISSN
2023 Impact Factor: 13.0
2023 SCImago Journal Rankings: 3.348
PubMed Central ID
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorZhu, Jixiang-
dc.contributor.authorZhou, Xingwu-
dc.contributor.authorKim, Han Jun-
dc.contributor.authorQu, Moyuan-
dc.contributor.authorJiang, Xing-
dc.contributor.authorLee, Kang Ju-
dc.contributor.authorRen, Li-
dc.contributor.authorWu, Qingzhi-
dc.contributor.authorWang, Canran-
dc.contributor.authorZhu, Xunmin-
dc.contributor.authorTebon, Peyton-
dc.contributor.authorZhang, Shiming-
dc.contributor.authorLee, Junmin-
dc.contributor.authorAshammakhi, Nureddin-
dc.contributor.authorAhadian, Samad-
dc.contributor.authorDokmeci, Mehmet Remzi-
dc.contributor.authorGu, Zhen-
dc.contributor.authorSun, Wujin-
dc.contributor.authorKhademhosseini, Ali-
dc.date.accessioned2021-01-18T15:46:50Z-
dc.date.available2021-01-18T15:46:50Z-
dc.date.issued2020-
dc.identifier.citationSmall, 2020, v. 16, n. 16, article no. 1905910-
dc.identifier.issn1613-6810-
dc.identifier.urihttp://hdl.handle.net/10722/295419-
dc.description.abstract© 2020 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim The extraction of interstitial fluid (ISF) from skin using microneedles (MNs) has attracted growing interest in recent years due to its potential for minimally invasive diagnostics and biosensors. ISF collection by absorption into a hydrogel MN patch is a promising way that requires the materials to have outstanding swelling ability. Here, a gelatin methacryloyl (GelMA) patch is developed with an 11 × 11 array of MNs for minimally invasive sampling of ISF. The properties of the patch can be tuned by altering the concentration of the GelMA prepolymer and the crosslinking time; patches are created with swelling ratios between 293% and 423% and compressive moduli between 3.34 MPa and 7.23 MPa. The optimized GelMA MN patch demonstrates efficient extraction of ISF. Furthermore, it efficiently and quantitatively detects glucose and vancomycin in ISF in an in vivo study. This minimally invasive approach of extracting ISF with a GelMA MN patch has the potential to complement blood sampling for the monitoring of target molecules from patients.-
dc.languageeng-
dc.relation.ispartofSmall-
dc.subjectskin interstitial fluid-
dc.subjectgelatin methacryloyl-
dc.subjectmicroneedle patches-
dc.subjecttransdermal extraction-
dc.subjectminimally invasive diagnostics-
dc.titleGelatin Methacryloyl Microneedle Patches for Minimally Invasive Extraction of Skin Interstitial Fluid-
dc.typeArticle-
dc.description.naturelink_to_OA_fulltext-
dc.identifier.doi10.1002/smll.201905910-
dc.identifier.pmid32101371-
dc.identifier.pmcidPMC7182487-
dc.identifier.scopuseid_2-s2.0-85080032471-
dc.identifier.volume16-
dc.identifier.issue16-
dc.identifier.spagearticle no. 1905910-
dc.identifier.epagearticle no. 1905910-
dc.identifier.eissn1613-6829-
dc.identifier.isiWOS:000516162100001-
dc.identifier.issnl1613-6810-

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