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Article: A Patch of Detachable Hybrid Microneedle Depot for Localized Delivery of Mesenchymal Stem Cells in Regeneration Therapy

TitleA Patch of Detachable Hybrid Microneedle Depot for Localized Delivery of Mesenchymal Stem Cells in Regeneration Therapy
Authors
Keywordsmicroneedle
regenerative therapy
biodegradable polymer
gelatin methacryloyl hydrogel
mesenchymal stem cell
Issue Date2020
Citation
Advanced Functional Materials, 2020, v. 30, n. 23, article no. 2000086 How to Cite?
Abstract© 2020 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim Mesenchymal stem cells (MSCs) have been widely used for regenerative therapy. In most current clinical applications, MSCs are delivered by injection but face significant issues with cell viability and penetration into the target tissue due to a limited migration capacity. Some therapies have attempted to improve MSC stability by their encapsulation within biomaterials; however, these treatments still require an enormous number of cells to achieve therapeutic efficacy due to low efficiency. Additionally, while local injection allows for targeted delivery, injections with conventional syringes are highly invasive. Due to the challenges associated with stem cell delivery, a local and minimally invasive approach with high efficiency and improved cell viability is highly desired. In this study, a detachable hybrid microneedle depot (d-HMND) for cell delivery is presented. The system consists of an array of microneedles with an outer poly(lactic-co-glycolic) acid shell and an internal gelatin methacryloyl (GelMA)-MSC mixture (GMM). The GMM is characterized and optimized for cell viability and mechanical strength of the d-HMND required to penetrate mouse skin tissue is also determined. MSC viability and function within the d-HMND is characterized in vitro and the regenerative efficacy of the d-HMND is demonstrated in vivo using a mouse skin wound model.
Persistent Identifierhttp://hdl.handle.net/10722/295422
ISSN
2020 Impact Factor: 18.808
2020 SCImago Journal Rankings: 6.069
PubMed Central ID
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorLee, Kang Ju-
dc.contributor.authorXue, Yumeng-
dc.contributor.authorLee, Junmin-
dc.contributor.authorKim, Han Jun-
dc.contributor.authorLiu, Yaowen-
dc.contributor.authorTebon, Peyton-
dc.contributor.authorSarikhani, Einollah-
dc.contributor.authorSun, Wujin-
dc.contributor.authorZhang, Shiming-
dc.contributor.authorHaghniaz, Reihaneh-
dc.contributor.authorÇelebi-Saltik, Betül-
dc.contributor.authorZhou, Xingwu-
dc.contributor.authorOstrovidov, Serge-
dc.contributor.authorAhadian, Samad-
dc.contributor.authorAshammakhi, Nureddin-
dc.contributor.authorDokmeci, Mehmet R.-
dc.contributor.authorKhademhosseini, Ali-
dc.date.accessioned2021-01-18T15:46:50Z-
dc.date.available2021-01-18T15:46:50Z-
dc.date.issued2020-
dc.identifier.citationAdvanced Functional Materials, 2020, v. 30, n. 23, article no. 2000086-
dc.identifier.issn1616-301X-
dc.identifier.urihttp://hdl.handle.net/10722/295422-
dc.description.abstract© 2020 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim Mesenchymal stem cells (MSCs) have been widely used for regenerative therapy. In most current clinical applications, MSCs are delivered by injection but face significant issues with cell viability and penetration into the target tissue due to a limited migration capacity. Some therapies have attempted to improve MSC stability by their encapsulation within biomaterials; however, these treatments still require an enormous number of cells to achieve therapeutic efficacy due to low efficiency. Additionally, while local injection allows for targeted delivery, injections with conventional syringes are highly invasive. Due to the challenges associated with stem cell delivery, a local and minimally invasive approach with high efficiency and improved cell viability is highly desired. In this study, a detachable hybrid microneedle depot (d-HMND) for cell delivery is presented. The system consists of an array of microneedles with an outer poly(lactic-co-glycolic) acid shell and an internal gelatin methacryloyl (GelMA)-MSC mixture (GMM). The GMM is characterized and optimized for cell viability and mechanical strength of the d-HMND required to penetrate mouse skin tissue is also determined. MSC viability and function within the d-HMND is characterized in vitro and the regenerative efficacy of the d-HMND is demonstrated in vivo using a mouse skin wound model.-
dc.languageeng-
dc.relation.ispartofAdvanced Functional Materials-
dc.subjectmicroneedle-
dc.subjectregenerative therapy-
dc.subjectbiodegradable polymer-
dc.subjectgelatin methacryloyl hydrogel-
dc.subjectmesenchymal stem cell-
dc.titleA Patch of Detachable Hybrid Microneedle Depot for Localized Delivery of Mesenchymal Stem Cells in Regeneration Therapy-
dc.typeArticle-
dc.description.naturelink_to_OA_fulltext-
dc.identifier.doi10.1002/adfm.202000086-
dc.identifier.pmid33071712-
dc.identifier.pmcidPMC7567343-
dc.identifier.scopuseid_2-s2.0-85084123137-
dc.identifier.volume30-
dc.identifier.issue23-
dc.identifier.spagearticle no. 2000086-
dc.identifier.epagearticle no. 2000086-
dc.identifier.eissn1616-3028-
dc.identifier.isiWOS:000528598900001-
dc.identifier.issnl1616-301X-

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