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Article: Biodegradable β-Cyclodextrin Conjugated Gelatin Methacryloyl Microneedle for Delivery of Water-Insoluble Drug

TitleBiodegradable β-Cyclodextrin Conjugated Gelatin Methacryloyl Microneedle for Delivery of Water-Insoluble Drug
Authors
Keywordsmicroneedles
β-cyclodextrin
gelatin methacryloyl
water insoluble drugs
transdermal delivery
Issue Date2020
Citation
Advanced Healthcare Materials, 2020, v. 9, n. 11, article no. 2000527 How to Cite?
Abstract© 2020 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim Transdermal delivery of water-insoluble drugs via hydrogel-based microneedle (MN) arrays is crucial for improving their therapeutic efficacies. However, direct loading of water-insoluble drug into hydrophilic matrices remains challenging. Here, a biodegradable MN array patch that is fabricated from naturally derived polymer conjugates of gelatin methacryloyl and β-cyclodextrin (GelMA-β-CD) is reported. When curcumin, an unstable and water-insoluble anticancer drug, is loaded as a model drug, its stability and solubility are improved due to the formation of an inclusion complex. The polymer-drug complex GelMA-β-CD/CUR can be formulated into MN arrays with sufficient mechanical strength for skin penetration and tunable drug release profile. Anticancer efficacy of released curcumin is observed in three-dimensional B16F10 melanoma models. The GelMA-β-CD/CUR MN exhibits relatively higher therapeutic efficacy through more localized and deeper penetrated manner compared with a control nontransdermal patch. In vivo studies also verify biocompatibility and degradability of the GelMA-β-CD MN arrays patch.
Persistent Identifierhttp://hdl.handle.net/10722/295432
ISSN
2020 Impact Factor: 9.933
2015 SCImago Journal Rankings: 2.396
PubMed Central ID
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorZhou, Xingwu-
dc.contributor.authorLuo, Zhimin-
dc.contributor.authorBaidya, Avijit-
dc.contributor.authorKim, Han jun-
dc.contributor.authorWang, Canran-
dc.contributor.authorJiang, Xing-
dc.contributor.authorQu, Moyuan-
dc.contributor.authorZhu, Jixiang-
dc.contributor.authorRen, Li-
dc.contributor.authorVajhadin, Fereshteh-
dc.contributor.authorTebon, Peyton-
dc.contributor.authorZhang, Niyuan-
dc.contributor.authorXue, Yumeng-
dc.contributor.authorFeng, Yudi-
dc.contributor.authorXue, Chengbin-
dc.contributor.authorChen, Yi-
dc.contributor.authorLee, Kang Ju-
dc.contributor.authorLee, Junmin-
dc.contributor.authorZhang, Shiming-
dc.contributor.authorXu, Chun-
dc.contributor.authorAshammakhi, Nureddin-
dc.contributor.authorAhadian, Samad-
dc.contributor.authorDokmeci, Mehmet Remzi-
dc.contributor.authorGu, Zhen-
dc.contributor.authorSun, Wujin-
dc.contributor.authorKhademhosseini, Ali-
dc.date.accessioned2021-01-18T15:46:51Z-
dc.date.available2021-01-18T15:46:51Z-
dc.date.issued2020-
dc.identifier.citationAdvanced Healthcare Materials, 2020, v. 9, n. 11, article no. 2000527-
dc.identifier.issn2192-2640-
dc.identifier.urihttp://hdl.handle.net/10722/295432-
dc.description.abstract© 2020 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim Transdermal delivery of water-insoluble drugs via hydrogel-based microneedle (MN) arrays is crucial for improving their therapeutic efficacies. However, direct loading of water-insoluble drug into hydrophilic matrices remains challenging. Here, a biodegradable MN array patch that is fabricated from naturally derived polymer conjugates of gelatin methacryloyl and β-cyclodextrin (GelMA-β-CD) is reported. When curcumin, an unstable and water-insoluble anticancer drug, is loaded as a model drug, its stability and solubility are improved due to the formation of an inclusion complex. The polymer-drug complex GelMA-β-CD/CUR can be formulated into MN arrays with sufficient mechanical strength for skin penetration and tunable drug release profile. Anticancer efficacy of released curcumin is observed in three-dimensional B16F10 melanoma models. The GelMA-β-CD/CUR MN exhibits relatively higher therapeutic efficacy through more localized and deeper penetrated manner compared with a control nontransdermal patch. In vivo studies also verify biocompatibility and degradability of the GelMA-β-CD MN arrays patch.-
dc.languageeng-
dc.relation.ispartofAdvanced Healthcare Materials-
dc.subjectmicroneedles-
dc.subjectβ-cyclodextrin-
dc.subjectgelatin methacryloyl-
dc.subjectwater insoluble drugs-
dc.subjecttransdermal delivery-
dc.titleBiodegradable β-Cyclodextrin Conjugated Gelatin Methacryloyl Microneedle for Delivery of Water-Insoluble Drug-
dc.typeArticle-
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1002/adhm.202000527-
dc.identifier.pmid32364331-
dc.identifier.pmcidPMC7462883-
dc.identifier.scopuseid_2-s2.0-85085121001-
dc.identifier.volume9-
dc.identifier.issue11-
dc.identifier.spagearticle no. 2000527-
dc.identifier.epagearticle no. 2000527-
dc.identifier.eissn2192-2659-
dc.identifier.isiWOS:000530449800001-
dc.identifier.issnl2192-2640-

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