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Conference Paper: Thirteen-year experience of high risk breast cancer surveillance for female BRCA mutation carriers in Hong Kong

TitleThirteen-year experience of high risk breast cancer surveillance for female BRCA mutation carriers in Hong Kong
Authors
Issue Date2020
PublisherWiley-Blackwell Publishing Asia. The Journal's web site is located at http://onlinelibrary.wiley.com/journal/10.1111/(ISSN)1744-1633
Citation
The Royal College of Surgeons of Edinburgh and The College of Surgeons of Hong Kong (RCSEd/CSHK) Conjoint Virtual Scientific Congress 2020: Towards Personalised Surgery, Hong Kong, 19 September 2020. In Surgical Practice, 2020, v. 24 n. Suppl. 1, p. 4, abstract no. PF3 How to Cite?
AbstractAim: Long‐term results of high‐risk breast cancer surveillance for BRCA mutation carriers are lacking for Asian population. This study aimed to review our 13‐year experience of high‐risk surveillance and assess the outcome of cancer detection and mortality. Methods: BRCA mutation carriers under Hong Kong Hereditary Breast Cancer Family Registry from January 2007 to December 2019 were reviewed. Surveillance program included biannual clinical examination, 6‐monthly breast imaging with alternating contrast magnetic resonance imaging and a combination of mammogram and ultrasound. Results: A total of 419 BRCA mutation carriers were managed under the registry; after excluding patients who had bilateral mastectomy before enrolling to the program, 346 patients were followed up in a median period of 39.4 (6–152) months. The uptake of risk‐reducing mastectomy was 5%, and particularly low in patients without breast cancer, only 2%. The new breast cancer detection rate was 1.75% (29 cancer diagnosed from 1656 screening imaging). Early cancer detection was achieved with 86.7% diagnosed in stage 0/1 and a node positive rate of 6.7%, with minimal interval cancer occurrence. Overall breast‐cancer specific mortality was 3.8%. In initially breast‐cancer free patients who later developed breast cancer during surveillance, breast‐cancer specific mortality was 0%. Overall survival was largely dependent on ovarian cancer history. Conclusions: Risk‐reducing mastectomy is not popular among Chinese BRCA mutation carriers. High‐risk breast cancer surveillance remained the core management and it could achieve early cancer detection with minimal interval cancer occurrence, and a low breast‐cancer specific mortality. Further study with cost‐effective analysis is warranted.
DescriptionOral Presentation - Free Paper - no. FP3
Persistent Identifierhttp://hdl.handle.net/10722/297191
ISSN
2023 Impact Factor: 0.3
2023 SCImago Journal Rankings: 0.152

 

DC FieldValueLanguage
dc.contributor.authorChang, YKR-
dc.contributor.authorLuk, WPL-
dc.contributor.authorFung, LH-
dc.contributor.authorKwong, A-
dc.date.accessioned2021-03-08T07:15:27Z-
dc.date.available2021-03-08T07:15:27Z-
dc.date.issued2020-
dc.identifier.citationThe Royal College of Surgeons of Edinburgh and The College of Surgeons of Hong Kong (RCSEd/CSHK) Conjoint Virtual Scientific Congress 2020: Towards Personalised Surgery, Hong Kong, 19 September 2020. In Surgical Practice, 2020, v. 24 n. Suppl. 1, p. 4, abstract no. PF3-
dc.identifier.issn1744-1625-
dc.identifier.urihttp://hdl.handle.net/10722/297191-
dc.descriptionOral Presentation - Free Paper - no. FP3-
dc.description.abstractAim: Long‐term results of high‐risk breast cancer surveillance for BRCA mutation carriers are lacking for Asian population. This study aimed to review our 13‐year experience of high‐risk surveillance and assess the outcome of cancer detection and mortality. Methods: BRCA mutation carriers under Hong Kong Hereditary Breast Cancer Family Registry from January 2007 to December 2019 were reviewed. Surveillance program included biannual clinical examination, 6‐monthly breast imaging with alternating contrast magnetic resonance imaging and a combination of mammogram and ultrasound. Results: A total of 419 BRCA mutation carriers were managed under the registry; after excluding patients who had bilateral mastectomy before enrolling to the program, 346 patients were followed up in a median period of 39.4 (6–152) months. The uptake of risk‐reducing mastectomy was 5%, and particularly low in patients without breast cancer, only 2%. The new breast cancer detection rate was 1.75% (29 cancer diagnosed from 1656 screening imaging). Early cancer detection was achieved with 86.7% diagnosed in stage 0/1 and a node positive rate of 6.7%, with minimal interval cancer occurrence. Overall breast‐cancer specific mortality was 3.8%. In initially breast‐cancer free patients who later developed breast cancer during surveillance, breast‐cancer specific mortality was 0%. Overall survival was largely dependent on ovarian cancer history. Conclusions: Risk‐reducing mastectomy is not popular among Chinese BRCA mutation carriers. High‐risk breast cancer surveillance remained the core management and it could achieve early cancer detection with minimal interval cancer occurrence, and a low breast‐cancer specific mortality. Further study with cost‐effective analysis is warranted.-
dc.languageeng-
dc.publisherWiley-Blackwell Publishing Asia. The Journal's web site is located at http://onlinelibrary.wiley.com/journal/10.1111/(ISSN)1744-1633-
dc.relation.ispartofSurgical Practice-
dc.relation.ispartofRCSEd/CSHK Conjoint Virtual Scientific Congress 2020-
dc.titleThirteen-year experience of high risk breast cancer surveillance for female BRCA mutation carriers in Hong Kong-
dc.typeConference_Paper-
dc.identifier.emailKwong, A: avakwong@hku.hk-
dc.identifier.authorityKwong, A=rp01734-
dc.description.natureabstract-
dc.identifier.hkuros321593-
dc.identifier.volume24-
dc.identifier.issueSuppl. 1-
dc.identifier.spage4, abstract no. PF3-
dc.identifier.epage4, abstract no. PF3-
dc.publisher.placeAustralia-
dc.identifier.partofdoi10.1111/1744-1633.12446-
dc.identifier.issnl1744-1625-

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