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- Publisher Website: 10.1111/omi.12333
- Scopus: eid_2-s2.0-85102788331
- PMID: 33721398
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Article: The multifaceted roles of antimicrobial peptides in oral diseases
Title | The multifaceted roles of antimicrobial peptides in oral diseases |
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Authors | |
Keywords | peptides caries prevention remineralization antimicrobial |
Issue Date | 2021 |
Publisher | Wiley-Blackwell Publishing, Inc.. The Journal's web site is located at http://www.wiley.com/bw/journal.asp?ref=2041-1006&site=1 |
Citation | Molecular Oral Microbiology, 2021, v. 36 n. 3, p. 159-171 How to Cite? |
Abstract | Antimicrobial peptides are naturally occurring protein molecules with antibacterial, antiviral and/or antifungal activity. Some antimicrobial peptides kill microorganisms through direct binding with negatively charged microbial surfaces. This action disrupts the cytoplasmic membrane and leads to the leakage of the cytoplasm. In addition, they are involved in the innate immune response. Antimicrobial peptides play an important role in oral health, as natural antimicrobial peptides are the first line of host defence in response to microbial infection. The level of natural antimicrobial peptides increases during severe disease conditions and play a role in promoting the healing of oral tissues. However, they are insufficient for eliminating pathogenic micro-organisms. The variability of the oral environment can markedly reduce the effect of natural antimicrobial peptides. Thus, researchers are developing synthetic antimicrobial peptides with promising stability and biocompatibility. Synthetic antimicrobial peptides are a potential alternative to traditional antimicrobial therapy. Pertinent to oral diseases, the deregulation of antimicrobial peptides is involved in the pathogenesis of dental caries, periodontal disease, mucosal disease and oral cancer, where they can kill pathogenic microorganisms, promote tissue healing, serve as biomarkers and inhibit tumour cells. This narrative review provides an overview of the multifaceted roles of antimicrobial peptides in oral diseases. |
Persistent Identifier | http://hdl.handle.net/10722/298695 |
ISSN | 2022 Impact Factor: 3.7 2020 SCImago Journal Rankings: 1.180 |
ISI Accession Number ID |
DC Field | Value | Language |
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dc.contributor.author | Niu, JY | - |
dc.contributor.author | Yin, IX | - |
dc.contributor.author | Mei, ML | - |
dc.contributor.author | Wu, WKK | - |
dc.contributor.author | Li, QL | - |
dc.contributor.author | Chu, CH | - |
dc.date.accessioned | 2021-04-12T03:02:07Z | - |
dc.date.available | 2021-04-12T03:02:07Z | - |
dc.date.issued | 2021 | - |
dc.identifier.citation | Molecular Oral Microbiology, 2021, v. 36 n. 3, p. 159-171 | - |
dc.identifier.issn | 2041-1006 | - |
dc.identifier.uri | http://hdl.handle.net/10722/298695 | - |
dc.description.abstract | Antimicrobial peptides are naturally occurring protein molecules with antibacterial, antiviral and/or antifungal activity. Some antimicrobial peptides kill microorganisms through direct binding with negatively charged microbial surfaces. This action disrupts the cytoplasmic membrane and leads to the leakage of the cytoplasm. In addition, they are involved in the innate immune response. Antimicrobial peptides play an important role in oral health, as natural antimicrobial peptides are the first line of host defence in response to microbial infection. The level of natural antimicrobial peptides increases during severe disease conditions and play a role in promoting the healing of oral tissues. However, they are insufficient for eliminating pathogenic micro-organisms. The variability of the oral environment can markedly reduce the effect of natural antimicrobial peptides. Thus, researchers are developing synthetic antimicrobial peptides with promising stability and biocompatibility. Synthetic antimicrobial peptides are a potential alternative to traditional antimicrobial therapy. Pertinent to oral diseases, the deregulation of antimicrobial peptides is involved in the pathogenesis of dental caries, periodontal disease, mucosal disease and oral cancer, where they can kill pathogenic microorganisms, promote tissue healing, serve as biomarkers and inhibit tumour cells. This narrative review provides an overview of the multifaceted roles of antimicrobial peptides in oral diseases. | - |
dc.language | eng | - |
dc.publisher | Wiley-Blackwell Publishing, Inc.. The Journal's web site is located at http://www.wiley.com/bw/journal.asp?ref=2041-1006&site=1 | - |
dc.relation.ispartof | Molecular Oral Microbiology | - |
dc.rights | This is the peer reviewed version of the following article: Molecular Oral Microbiology, 2021, v. 36 n. 3, p. 159-171, which has been published in final form at https://doi.org/10.1111/omi.12333. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Use of Self-Archived Versions. | - |
dc.subject | peptides | - |
dc.subject | caries | - |
dc.subject | prevention | - |
dc.subject | remineralization | - |
dc.subject | antimicrobial | - |
dc.title | The multifaceted roles of antimicrobial peptides in oral diseases | - |
dc.type | Article | - |
dc.identifier.email | Yin, IX: irisxyin@hku.hk | - |
dc.identifier.email | Chu, CH: chchu@hku.hk | - |
dc.identifier.authority | Chu, CH=rp00022 | - |
dc.description.nature | postprint | - |
dc.identifier.doi | 10.1111/omi.12333 | - |
dc.identifier.pmid | 33721398 | - |
dc.identifier.scopus | eid_2-s2.0-85102788331 | - |
dc.identifier.hkuros | 322054 | - |
dc.identifier.volume | 36 | - |
dc.identifier.issue | 3 | - |
dc.identifier.spage | 159 | - |
dc.identifier.epage | 171 | - |
dc.identifier.isi | WOS:000631671500001 | - |
dc.publisher.place | United States | - |