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Article: Placental Site Trophoblastic Tumor: A Distinct Entity of Gestational Trophoblastic Disease Experience from a Tertiary Referral Center in Hong Kong

TitlePlacental Site Trophoblastic Tumor: A Distinct Entity of Gestational Trophoblastic Disease Experience from a Tertiary Referral Center in Hong Kong
Authors
KeywordsChemotherapy
Choriocarcinoma
Gestational trophoblastic disease
Gestational trophoblastic neoplasia
Hysterectomy
Issue Date2016
PublisherJournal of Reproductive Medicine, Inc. The Journal's web site is located at http://www.reproductivemedicine.com
Citation
Journal of Reproductive Medicine, 2016, v. 61 n. 4, p. 351-356 How to Cite?
AbstractObjective: To review the clinical and pathological characteristics of patients with placental site trophoblastic tumor (PS TT) managed in a tertiary referral center in Hong Kong. Study design: Patients with a diagnosis of PSTT from 1995 to 2012 were identified from a computer database. Clinical and patho- logical data were obtained from medical records and the electronic database. Results: Ten patients with PSTT were identified. Only 4 patients (40%) had disease confined to the uterus at presentation (Stage I). The most common site of metastasis was the lung. Four patients had pretreatment serum hCG levels <1,000 IU/L, and all of them had disease 'confined to the uterus. Of the 4 patients with Stage I disease 3 had hysterectomy only and 1 had both hysterectomy and chemotherapy. All 4 patients achieved complete remission; although 1 of them had a recurrence successfully treated with che- motherapy. For patients with Stage III/IV disease most of them had both hysterectomy and chemotherapy. Only 1 patient (20%) was alive without evidence of disease. Conclusion: Patients with Stage I disease have excellent prognosis after hysterectomy, and adjuvant treatment is not recommended. A low pretreatment serum hCG level (<1,000 IU/L) was a good predictor of early stage disease. The prognosis for patients with metastatic disease was poor despite surgery and com- bination chemotherapy.
Persistent Identifierhttp://hdl.handle.net/10722/298727
ISSN
2022 Impact Factor: 0.2
2023 SCImago Journal Rankings: 0.103

 

DC FieldValueLanguage
dc.contributor.authorChu, MYM-
dc.contributor.authorTse, K-
dc.contributor.authorChan, KKL-
dc.contributor.authorCheung, ANY-
dc.contributor.authorNgan, HYS-
dc.date.accessioned2021-04-12T03:02:33Z-
dc.date.available2021-04-12T03:02:33Z-
dc.date.issued2016-
dc.identifier.citationJournal of Reproductive Medicine, 2016, v. 61 n. 4, p. 351-356-
dc.identifier.issn0024-7758-
dc.identifier.urihttp://hdl.handle.net/10722/298727-
dc.description.abstractObjective: To review the clinical and pathological characteristics of patients with placental site trophoblastic tumor (PS TT) managed in a tertiary referral center in Hong Kong. Study design: Patients with a diagnosis of PSTT from 1995 to 2012 were identified from a computer database. Clinical and patho- logical data were obtained from medical records and the electronic database. Results: Ten patients with PSTT were identified. Only 4 patients (40%) had disease confined to the uterus at presentation (Stage I). The most common site of metastasis was the lung. Four patients had pretreatment serum hCG levels <1,000 IU/L, and all of them had disease 'confined to the uterus. Of the 4 patients with Stage I disease 3 had hysterectomy only and 1 had both hysterectomy and chemotherapy. All 4 patients achieved complete remission; although 1 of them had a recurrence successfully treated with che- motherapy. For patients with Stage III/IV disease most of them had both hysterectomy and chemotherapy. Only 1 patient (20%) was alive without evidence of disease. Conclusion: Patients with Stage I disease have excellent prognosis after hysterectomy, and adjuvant treatment is not recommended. A low pretreatment serum hCG level (<1,000 IU/L) was a good predictor of early stage disease. The prognosis for patients with metastatic disease was poor despite surgery and com- bination chemotherapy.-
dc.languageeng-
dc.publisherJournal of Reproductive Medicine, Inc. The Journal's web site is located at http://www.reproductivemedicine.com-
dc.relation.ispartofJournal of Reproductive Medicine-
dc.subjectChemotherapy-
dc.subjectChoriocarcinoma-
dc.subjectGestational trophoblastic disease-
dc.subjectGestational trophoblastic neoplasia-
dc.subjectHysterectomy-
dc.titlePlacental Site Trophoblastic Tumor: A Distinct Entity of Gestational Trophoblastic Disease Experience from a Tertiary Referral Center in Hong Kong-
dc.typeArticle-
dc.identifier.emailChu, MYM: chumy@hku.hk-
dc.identifier.emailTse, K: tseky@hku.hk-
dc.identifier.emailChan, KKL: kklchan@hkucc.hku.hk-
dc.identifier.emailCheung, ANY: anycheun@hkucc.hku.hk-
dc.identifier.emailNgan, HYS: hysngan@hkucc.hku.hk-
dc.identifier.authorityTse, K=rp02391-
dc.identifier.authorityChan, KKL=rp00499-
dc.identifier.authorityCheung, ANY=rp00542-
dc.identifier.authorityNgan, HYS=rp00346-
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.pmid30408381-
dc.identifier.scopuseid_2-s2.0-84978698457-
dc.identifier.hkuros322090-
dc.identifier.volume61-
dc.identifier.issue4-
dc.identifier.spage351-
dc.identifier.epage356-
dc.publisher.placeUnited States-

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