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Article: A Multi-Element-Doped Porous Bioactive Glass Coating for Implant Applications

TitleA Multi-Element-Doped Porous Bioactive Glass Coating for Implant Applications
Authors
Keywordstitanium
bioactive glass
implant coating
antibacterial
cell cytotoxicity
Issue Date2021
PublisherMDPIAG. The Journal's web site is located at http://www.mdpi.com/journal/materials/
Citation
Materials, 2021, v. 14 n. 4, p. article no. 961 How to Cite?
AbstractObjectives: The objectives of the study were (1) to develop a novel multi-element-doped porous 58S bioactive glass coating for titanium implants and (2) to investigate the physiochemical, cell cytotoxic and antibacterial properties of this novel coating for titanium implants. Methods: This study employed the sol–gel method to develop a silver-, cobalt (II) oxide- and titanium dioxide-doped 58S bioactive glass coating. The surface topography and in vitro bioactivity of the new bioactive glass-coated implants were studied using scanning electron microscopy (SEM) and energy-dispersive X-ray spectroscopy. The surface nanohardness and coating degradation were evaluated using atomic force microscopy (AFM) and inductively coupled plasma atomic emission spectroscopy (ICP-AES), respectively. The cell cytotoxicity was assessed using cell viability of osteoblast-like mouse cells. The antibacterial property was examined using colony-forming units (CFUs) of the implant coating against Porphyromonas gingivalis. Results: The multi-element-doped porous 58S bioactive glass-coated titanium implant was synthesized. SEM showed that calcium phosphate was formed on the novel coating but not on the 58S bioactive glass coating. The mean surface nanohardness of the novel coating and the 58S coating were 124 ± 24 and 50 ± 17 MPa, respectively (p < 0.001). ICP-AES showed that the releases of Si, Ca and P ions of the novel coating were significantly higher than that of a 58S bioactive glass-coated implant. No significant difference in cell cytotoxicity was found between the novel coating and the 58S coating (p > 0.1). The mean CFUs of the novel coating and the conventional coating were 120 × 106 and 49 × 106 /mL. Conclusion: A novel multielement-doped porous bioactive glass coating for titanium implants was developed. The coating displays promising biocompatibility and antibacterial activity. Clinical significance: the coating can be used to improve the clinical success of dental implants for patient care if it shows success in clinical trials.
Persistent Identifierhttp://hdl.handle.net/10722/298750
ISSN
2018 Impact Factor: 2.972
2015 SCImago Journal Rankings: 0.873
PubMed Central ID

 

DC FieldValueLanguage
dc.contributor.authorLung, CYK-
dc.contributor.authorAbdalla, MM-
dc.contributor.authorChu, CH-
dc.contributor.authorYin, I-
dc.contributor.authorGot, SR-
dc.contributor.authorMatinlinna, JP-
dc.date.accessioned2021-04-12T03:02:52Z-
dc.date.available2021-04-12T03:02:52Z-
dc.date.issued2021-
dc.identifier.citationMaterials, 2021, v. 14 n. 4, p. article no. 961-
dc.identifier.issn1996-1944-
dc.identifier.urihttp://hdl.handle.net/10722/298750-
dc.description.abstractObjectives: The objectives of the study were (1) to develop a novel multi-element-doped porous 58S bioactive glass coating for titanium implants and (2) to investigate the physiochemical, cell cytotoxic and antibacterial properties of this novel coating for titanium implants. Methods: This study employed the sol–gel method to develop a silver-, cobalt (II) oxide- and titanium dioxide-doped 58S bioactive glass coating. The surface topography and in vitro bioactivity of the new bioactive glass-coated implants were studied using scanning electron microscopy (SEM) and energy-dispersive X-ray spectroscopy. The surface nanohardness and coating degradation were evaluated using atomic force microscopy (AFM) and inductively coupled plasma atomic emission spectroscopy (ICP-AES), respectively. The cell cytotoxicity was assessed using cell viability of osteoblast-like mouse cells. The antibacterial property was examined using colony-forming units (CFUs) of the implant coating against Porphyromonas gingivalis. Results: The multi-element-doped porous 58S bioactive glass-coated titanium implant was synthesized. SEM showed that calcium phosphate was formed on the novel coating but not on the 58S bioactive glass coating. The mean surface nanohardness of the novel coating and the 58S coating were 124 ± 24 and 50 ± 17 MPa, respectively (p < 0.001). ICP-AES showed that the releases of Si, Ca and P ions of the novel coating were significantly higher than that of a 58S bioactive glass-coated implant. No significant difference in cell cytotoxicity was found between the novel coating and the 58S coating (p > 0.1). The mean CFUs of the novel coating and the conventional coating were 120 × 106 and 49 × 106 /mL. Conclusion: A novel multielement-doped porous bioactive glass coating for titanium implants was developed. The coating displays promising biocompatibility and antibacterial activity. Clinical significance: the coating can be used to improve the clinical success of dental implants for patient care if it shows success in clinical trials.-
dc.languageeng-
dc.publisherMDPIAG. The Journal's web site is located at http://www.mdpi.com/journal/materials/-
dc.relation.ispartofMaterials-
dc.rightsThis work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.-
dc.subjecttitanium-
dc.subjectbioactive glass-
dc.subjectimplant coating-
dc.subjectantibacterial-
dc.subjectcell cytotoxicity-
dc.titleA Multi-Element-Doped Porous Bioactive Glass Coating for Implant Applications-
dc.typeArticle-
dc.identifier.emailChu, CH: chchu@hku.hk-
dc.identifier.emailYin, I: irisxyin@hku.hk-
dc.identifier.authorityChu, CH=rp00022-
dc.description.naturepublished_or_final_version-
dc.identifier.doi10.3390/ma14040961-
dc.identifier.pmid33670658-
dc.identifier.pmcidPMC7922910-
dc.identifier.scopuseid_2-s2.0-85101902016-
dc.identifier.hkuros322035-
dc.identifier.volume14-
dc.identifier.issue4-
dc.identifier.spagearticle no. 961-
dc.identifier.epagearticle no. 961-
dc.publisher.placeSwitzerland-

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