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Article: The effects of strontium-doped bioactive glass and fluoride on hydroxyapatite crystallization

TitleThe effects of strontium-doped bioactive glass and fluoride on hydroxyapatite crystallization
Authors
KeywordsBioactive glass
Strontium
Hydroxyapatite
Fluorohydroxyapatite
Mineral crystallization
Issue Date2021
PublisherElsevier Ltd. The Journal's web site is located at http://www.elsevier.com/locate/jdent
Citation
Journal of Dentistry, 2021, v. 105, p. article no. 103581 How to Cite?
AbstractObjectives: This study investigated the effects of a new strontium-doped bioactive glass and fluoride on hydroxyapatite crystallization. Methods: We designed an in vitro experiment with calcium phosphate (CaCl2⋅2H2O + K2HPO4 in buffer solution) with different concentrations of strontium-doped bioactive glass (1 mg/mL or 5 mg/mL), and different concentrations of fluoride (0 ppm, 1 ppm or 5 ppm). Tris-buffered saline served as negative control. After incubation at 37 ℃ for 48 h, the shape and organization of crystals were examined by transmission electron microscopy (TEM) and electron diffraction. Structure of the crystals was assessed by powder X-ray diffraction (P-XRD) and unit cell parameters were calculated. Characterization of the crystals were performed by Raman spectroscopy and Fourier Transform Infrared Spectroscopy (FTIR). Results: TEM and selected-area electron diffraction revealed that the precipitates in all experimental groups were crystalline apatite. There was an interaction between strontium and fluoride with different concentrations on crystal thickness (p = 0.008). P-XRD indicated the formation of strontium-substituted-fluorohydroxyapatite and strontium-substituted-hydroxyapatite in the groups with both bioactive glass and fluoride. Expansion or contraction of crystal unit cell was influenced by the concentrations of strontium and fluoride. Raman spectra showed strong phosphate band at 960 cm− 1 in all experimental groups and displayed no obvious shift. FTIR results confirmed the formation of apatite. Conclusions: The results of this study suggest that strontium-doped bioactive glass and fluoride have synergistic effects on hydroxyapatite crystallization. Clinical Significance: Strontium-doped bioactive glass and fluoride have synergistic effects on hydroxyapatite crystallization by producing strontium-substituted-hydroxyapatite and strontium-substituted-fluorohydroxyapatite with enhanced bioactivity and reduced solubility which could be beneficial for caries management.
Persistent Identifierhttp://hdl.handle.net/10722/298758
ISSN
2019 Impact Factor: 3.242
2015 SCImago Journal Rankings: 1.029

 

DC FieldValueLanguage
dc.contributor.authorDai, LL-
dc.contributor.authorNudelman, F-
dc.contributor.authorChu, CH-
dc.contributor.authorLo, ECM-
dc.contributor.authorMei, ML-
dc.date.accessioned2021-04-12T03:02:59Z-
dc.date.available2021-04-12T03:02:59Z-
dc.date.issued2021-
dc.identifier.citationJournal of Dentistry, 2021, v. 105, p. article no. 103581-
dc.identifier.issn0300-5712-
dc.identifier.urihttp://hdl.handle.net/10722/298758-
dc.description.abstractObjectives: This study investigated the effects of a new strontium-doped bioactive glass and fluoride on hydroxyapatite crystallization. Methods: We designed an in vitro experiment with calcium phosphate (CaCl2⋅2H2O + K2HPO4 in buffer solution) with different concentrations of strontium-doped bioactive glass (1 mg/mL or 5 mg/mL), and different concentrations of fluoride (0 ppm, 1 ppm or 5 ppm). Tris-buffered saline served as negative control. After incubation at 37 ℃ for 48 h, the shape and organization of crystals were examined by transmission electron microscopy (TEM) and electron diffraction. Structure of the crystals was assessed by powder X-ray diffraction (P-XRD) and unit cell parameters were calculated. Characterization of the crystals were performed by Raman spectroscopy and Fourier Transform Infrared Spectroscopy (FTIR). Results: TEM and selected-area electron diffraction revealed that the precipitates in all experimental groups were crystalline apatite. There was an interaction between strontium and fluoride with different concentrations on crystal thickness (p = 0.008). P-XRD indicated the formation of strontium-substituted-fluorohydroxyapatite and strontium-substituted-hydroxyapatite in the groups with both bioactive glass and fluoride. Expansion or contraction of crystal unit cell was influenced by the concentrations of strontium and fluoride. Raman spectra showed strong phosphate band at 960 cm− 1 in all experimental groups and displayed no obvious shift. FTIR results confirmed the formation of apatite. Conclusions: The results of this study suggest that strontium-doped bioactive glass and fluoride have synergistic effects on hydroxyapatite crystallization. Clinical Significance: Strontium-doped bioactive glass and fluoride have synergistic effects on hydroxyapatite crystallization by producing strontium-substituted-hydroxyapatite and strontium-substituted-fluorohydroxyapatite with enhanced bioactivity and reduced solubility which could be beneficial for caries management.-
dc.languageeng-
dc.publisherElsevier Ltd. The Journal's web site is located at http://www.elsevier.com/locate/jdent-
dc.relation.ispartofJournal of Dentistry-
dc.subjectBioactive glass-
dc.subjectStrontium-
dc.subjectHydroxyapatite-
dc.subjectFluorohydroxyapatite-
dc.subjectMineral crystallization-
dc.titleThe effects of strontium-doped bioactive glass and fluoride on hydroxyapatite crystallization-
dc.typeArticle-
dc.identifier.emailChu, CH: chchu@hku.hk-
dc.identifier.emailLo, ECM: edward-lo@hku.hk-
dc.identifier.emailMei, ML: mei1123@hku.hk-
dc.identifier.authorityChu, CH=rp00022-
dc.identifier.authorityLo, ECM=rp00015-
dc.identifier.authorityMei, ML=rp01840-
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1016/j.jdent.2021.103581-
dc.identifier.pmid33434634-
dc.identifier.scopuseid_2-s2.0-8509934346-
dc.identifier.hkuros322052-
dc.identifier.volume105-
dc.identifier.spagearticle no. 103581-
dc.identifier.epagearticle no. 103581-
dc.publisher.placeUnited Kingdom-

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