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Article: Remineralizing effect of a new strontium-doped bioactive glass and fluoride on demineralized enamel and dentine
Title | Remineralizing effect of a new strontium-doped bioactive glass and fluoride on demineralized enamel and dentine |
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Authors | |
Keywords | Bioactive glass Fluoride Remineralization Enamel Dentine |
Issue Date | 2021 |
Publisher | Elsevier Ltd. The Journal's web site is located at http://www.elsevier.com/locate/jdent |
Citation | Journal of Dentistry, 2021, v. 108, article no. 103633 How to Cite? |
Abstract | Objective: To investigate the remineralizing effect of a strontium-doped bioactive glass (HX-BGC) and fluoride on demineralized enamel and dentine. Materials: Sixty demineralized human tooth specimens were allocated to four groups. Group 1 received 5% HX-BGC, Group 2 received 5% HX-BGC and 1,450 ppm fluoride, Group 3 received 1,450 ppm fluoride, and Group 4 received deionized water as negative control. The specimens were subjected to pH cycling for 14 days. The surface morphology, lesion depths, crystal characteristics and collagen matrix degradation of the specimens were assessed by scanning electron microscopy (SEM), micro-computed tomography (mico-CT), X-ray diffraction (XRD), and spectrophotometry with a hydroxyproline (HYP) assay, respectively. Results: SEM images showed the enamel surface was smooth with regularly arranged enamel rods in Groups 1 to 3. Granular grains were observed in both inter-tubular and intra-tubular dentine in Groups 1 to 3. The mean lesion depths in enamel were 80.8 μm, 50.6 μm, 72.7 μm and 130.7 μm in Groups 1 to 4, respectively (p < 0.001), and those in dentin were 152.06 μm, 140.9 μm, 165.4 μm and 214.1 μm, respectively (P < 0.001). The differences in mean mineral loss in enamel and in dentine between the four study groups follow the same pattern as that of the differences in lesion depth. XRD illustrated apatite formation in each group. There were no significant differences in the HYP concentrations among the four groups (p = 0.261). Conclusion: Combined use of HX-BGC and fluoride can reduce mineral loss and promote remineralization of demineralized enamel and dentine through the precipitation of newly formed apatite. Clinical significance: Adjunctive use of HX-BGC may enhance the remineralization effect of fluoride in the management of early dental caries lesions. |
Persistent Identifier | http://hdl.handle.net/10722/298798 |
ISSN | 2023 Impact Factor: 4.8 2023 SCImago Journal Rankings: 1.313 |
ISI Accession Number ID |
DC Field | Value | Language |
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dc.contributor.author | Dai, LL | - |
dc.contributor.author | Mei, ML | - |
dc.contributor.author | Chu, CH | - |
dc.contributor.author | Lo, ECM | - |
dc.date.accessioned | 2021-04-12T03:03:31Z | - |
dc.date.available | 2021-04-12T03:03:31Z | - |
dc.date.issued | 2021 | - |
dc.identifier.citation | Journal of Dentistry, 2021, v. 108, article no. 103633 | - |
dc.identifier.issn | 0300-5712 | - |
dc.identifier.uri | http://hdl.handle.net/10722/298798 | - |
dc.description.abstract | Objective: To investigate the remineralizing effect of a strontium-doped bioactive glass (HX-BGC) and fluoride on demineralized enamel and dentine. Materials: Sixty demineralized human tooth specimens were allocated to four groups. Group 1 received 5% HX-BGC, Group 2 received 5% HX-BGC and 1,450 ppm fluoride, Group 3 received 1,450 ppm fluoride, and Group 4 received deionized water as negative control. The specimens were subjected to pH cycling for 14 days. The surface morphology, lesion depths, crystal characteristics and collagen matrix degradation of the specimens were assessed by scanning electron microscopy (SEM), micro-computed tomography (mico-CT), X-ray diffraction (XRD), and spectrophotometry with a hydroxyproline (HYP) assay, respectively. Results: SEM images showed the enamel surface was smooth with regularly arranged enamel rods in Groups 1 to 3. Granular grains were observed in both inter-tubular and intra-tubular dentine in Groups 1 to 3. The mean lesion depths in enamel were 80.8 μm, 50.6 μm, 72.7 μm and 130.7 μm in Groups 1 to 4, respectively (p < 0.001), and those in dentin were 152.06 μm, 140.9 μm, 165.4 μm and 214.1 μm, respectively (P < 0.001). The differences in mean mineral loss in enamel and in dentine between the four study groups follow the same pattern as that of the differences in lesion depth. XRD illustrated apatite formation in each group. There were no significant differences in the HYP concentrations among the four groups (p = 0.261). Conclusion: Combined use of HX-BGC and fluoride can reduce mineral loss and promote remineralization of demineralized enamel and dentine through the precipitation of newly formed apatite. Clinical significance: Adjunctive use of HX-BGC may enhance the remineralization effect of fluoride in the management of early dental caries lesions. | - |
dc.language | eng | - |
dc.publisher | Elsevier Ltd. The Journal's web site is located at http://www.elsevier.com/locate/jdent | - |
dc.relation.ispartof | Journal of Dentistry | - |
dc.rights | This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License | - |
dc.subject | Bioactive glass | - |
dc.subject | Fluoride | - |
dc.subject | Remineralization | - |
dc.subject | Enamel | - |
dc.subject | Dentine | - |
dc.title | Remineralizing effect of a new strontium-doped bioactive glass and fluoride on demineralized enamel and dentine | - |
dc.type | Article | - |
dc.identifier.email | Chu, CH: chchu@hku.hk | - |
dc.identifier.email | Lo, ECM: edward-lo@hku.hk | - |
dc.identifier.authority | Chu, CH=rp00022 | - |
dc.identifier.authority | Lo, ECM=rp00015 | - |
dc.description.nature | postprint | - |
dc.identifier.doi | 10.1016/j.jdent.2021.103633 | - |
dc.identifier.pmid | 33716101 | - |
dc.identifier.scopus | eid_2-s2.0-85102869137 | - |
dc.identifier.hkuros | 322053 | - |
dc.identifier.volume | 108 | - |
dc.identifier.spage | article no. 103633 | - |
dc.identifier.epage | article no. 103633 | - |
dc.identifier.isi | WOS:000646275300012 | - |
dc.publisher.place | United Kingdom | - |