File Download

There are no files associated with this item.

  Links for fulltext
     (May Require Subscription)
Supplementary

Article: Prelimbic cortical stimulation disrupts fear memory consolidation through ventral hippocampal dopamine D2 receptors

TitlePrelimbic cortical stimulation disrupts fear memory consolidation through ventral hippocampal dopamine D2 receptors
Authors
Keywordsanxiety
deep brain stimulation
dopamine
fear
memory
Issue Date2021
PublisherJohn Wiley & Sons Ltd. The Journal's web site is located at http://www.wiley.com/bw/journal.asp?ref=0007-1188&site=1
Citation
British Journal of Pharmacology, 2021, Epub 2021-04-26 How to Cite?
AbstractBackground and purpose: Anxiety disorders pose one of the biggest threats to mental health worldwide, yet current therapeutics have been mostly ineffective due to issues with relapse, efficacy and toxicity of the medications. Deep brain stimulation (DBS) is a promising therapy for treatment-resistant psychiatric disorders including anxiety, but very little is known about the effects of deep brain stimulation on fear memories. Experimental approach: In this study, we employed a standard tone-footshock fear conditioning paradigm and modified plus maze discriminative avoidance task to probe the effects of prelimbic cortex deep brain stimulation on various stages of memory. Key results: We identified memory consolidation stage as a critical time point to disrupt fear memory via prelimbic cortex deep brain stimulation. The observed disruption was partially modulated by the inactivation of the ventral hippocampus and the transient changes in ventral hippocampus dopamine (D2 ) receptors expression upon prelimbic cortex deep brain stimulation. We also observed wide-scale changes of various neurotransmitters and their metabolites in ventral hippocampus, confirming its important role in response to prelimbic cortex deep brain stimulation. Conclusion and implications: These findings highlight the molecular mechanism in the ventral hippocampus in response to prelimbic cortex stimulation and may have translational value, indicating that targeting the prelimbic cortex in the memory consolidation stage via non-invasive neuromodulation techniques may be a feasible therapeutic strategy against anxiety disorders.
Persistent Identifierhttp://hdl.handle.net/10722/299138
ISSN
2020 Impact Factor: 8.739
2015 SCImago Journal Rankings: 2.368

 

DC FieldValueLanguage
dc.contributor.authorTan, SZK-
dc.contributor.authorPoon, CH-
dc.contributor.authorChan, YS-
dc.contributor.authorLim, LW-
dc.date.accessioned2021-04-28T02:26:41Z-
dc.date.available2021-04-28T02:26:41Z-
dc.date.issued2021-
dc.identifier.citationBritish Journal of Pharmacology, 2021, Epub 2021-04-26-
dc.identifier.issn0007-1188-
dc.identifier.urihttp://hdl.handle.net/10722/299138-
dc.description.abstractBackground and purpose: Anxiety disorders pose one of the biggest threats to mental health worldwide, yet current therapeutics have been mostly ineffective due to issues with relapse, efficacy and toxicity of the medications. Deep brain stimulation (DBS) is a promising therapy for treatment-resistant psychiatric disorders including anxiety, but very little is known about the effects of deep brain stimulation on fear memories. Experimental approach: In this study, we employed a standard tone-footshock fear conditioning paradigm and modified plus maze discriminative avoidance task to probe the effects of prelimbic cortex deep brain stimulation on various stages of memory. Key results: We identified memory consolidation stage as a critical time point to disrupt fear memory via prelimbic cortex deep brain stimulation. The observed disruption was partially modulated by the inactivation of the ventral hippocampus and the transient changes in ventral hippocampus dopamine (D2 ) receptors expression upon prelimbic cortex deep brain stimulation. We also observed wide-scale changes of various neurotransmitters and their metabolites in ventral hippocampus, confirming its important role in response to prelimbic cortex deep brain stimulation. Conclusion and implications: These findings highlight the molecular mechanism in the ventral hippocampus in response to prelimbic cortex stimulation and may have translational value, indicating that targeting the prelimbic cortex in the memory consolidation stage via non-invasive neuromodulation techniques may be a feasible therapeutic strategy against anxiety disorders.-
dc.languageeng-
dc.publisherJohn Wiley & Sons Ltd. The Journal's web site is located at http://www.wiley.com/bw/journal.asp?ref=0007-1188&site=1-
dc.relation.ispartofBritish Journal of Pharmacology-
dc.subjectanxiety-
dc.subjectdeep brain stimulation-
dc.subjectdopamine-
dc.subjectfear-
dc.subjectmemory-
dc.titlePrelimbic cortical stimulation disrupts fear memory consolidation through ventral hippocampal dopamine D2 receptors-
dc.typeArticle-
dc.identifier.emailChan, YS: yschan@hku.hk-
dc.identifier.emailLim, LW: limlw@hku.hk-
dc.identifier.authorityChan, YS=rp00318-
dc.identifier.authorityLim, LW=rp02088-
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1111/bph.15505-
dc.identifier.pmid33899943-
dc.identifier.hkuros322275-
dc.publisher.placeUnited Kingdom-

Export via OAI-PMH Interface in XML Formats


OR


Export to Other Non-XML Formats