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- Publisher Website: 10.1007/s00455-021-10311-6
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- PMID: 33909131
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Article: The relationships between radiation dosage and long-term swallowing kinematics and timing in nasopharyngeal carcinoma survivors
Title | The relationships between radiation dosage and long-term swallowing kinematics and timing in nasopharyngeal carcinoma survivors |
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Authors | |
Keywords | Nasopharyngeal carcinoma Head and neck cancer Intensity-modulated radiotherapy Radiation dosage Deglutition disorders |
Issue Date | 2021 |
Publisher | Springer New York LLC. The Journal's web site is located at http://link.springer.de/link/service/journals/00455/ |
Citation | Dysphagia, 2021, Epub on 2021-04-28 How to Cite? |
Abstract | This study aimed to investigate the relationship between intensity-modulated radiation therapy (IMRT) dosimetry and swallowing kinematic and timing measures. Thirteen kinematic and timing measures of swallowing from videofluoroscopic analysis were used as outcome measures to reflect swallowing function. IMRT dosimetry was accessed for thirteen swallowing-related structures. A cohort of 44 nasopharyngeal carcinoma (NPC) survivors at least 3 years post-IMRT were recruited. The cohort had a mean age of 53.2 ± 11.9 years, 77.3% of whom were male. There was an average of 68.24 ± 14.15 months since end of IMRT; 41 (93.2%) had undergone concurrent chemotherapy. For displacement measures, female sex and higher doses to the cricopharyngeus, glottic larynx, and base of tongue were associated with reduced hyolaryngeal excursion and pharyngeal constriction, and more residue. For timing measures, higher dose to the genioglossus was associated with reduced processing time at all stages of the swallow. The inferior pharyngeal constrictor emerged with a distinctly different pattern of association with mean radiation dosage compared to other structures. Greater changes to swallowing kinematics and timing were observed for pudding thick consistency than thin liquid. Increasing radiation dosage to swallowing-related structures is associated with reduced swallowing kinematics. However, not all structures are affected the same way, therefore organ sparing during treatment planning for IMRT needs to consider function rather than focusing on select muscles. Dose-response relationships should be investigated with a comprehensive set of swallowing structures to capture the holistic process of swallowing. |
Description | Hybrid open access |
Persistent Identifier | http://hdl.handle.net/10722/299309 |
ISSN | 2023 Impact Factor: 2.2 2023 SCImago Journal Rankings: 0.657 |
ISI Accession Number ID |
DC Field | Value | Language |
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dc.contributor.author | Pu, D | - |
dc.contributor.author | Lee, VHF | - |
dc.contributor.author | Chan, KMK | - |
dc.contributor.author | Yuen, MTY | - |
dc.contributor.author | Quon, H | - |
dc.contributor.author | Tsang, RKY | - |
dc.date.accessioned | 2021-05-10T06:59:58Z | - |
dc.date.available | 2021-05-10T06:59:58Z | - |
dc.date.issued | 2021 | - |
dc.identifier.citation | Dysphagia, 2021, Epub on 2021-04-28 | - |
dc.identifier.issn | 0179-051X | - |
dc.identifier.uri | http://hdl.handle.net/10722/299309 | - |
dc.description | Hybrid open access | - |
dc.description.abstract | This study aimed to investigate the relationship between intensity-modulated radiation therapy (IMRT) dosimetry and swallowing kinematic and timing measures. Thirteen kinematic and timing measures of swallowing from videofluoroscopic analysis were used as outcome measures to reflect swallowing function. IMRT dosimetry was accessed for thirteen swallowing-related structures. A cohort of 44 nasopharyngeal carcinoma (NPC) survivors at least 3 years post-IMRT were recruited. The cohort had a mean age of 53.2 ± 11.9 years, 77.3% of whom were male. There was an average of 68.24 ± 14.15 months since end of IMRT; 41 (93.2%) had undergone concurrent chemotherapy. For displacement measures, female sex and higher doses to the cricopharyngeus, glottic larynx, and base of tongue were associated with reduced hyolaryngeal excursion and pharyngeal constriction, and more residue. For timing measures, higher dose to the genioglossus was associated with reduced processing time at all stages of the swallow. The inferior pharyngeal constrictor emerged with a distinctly different pattern of association with mean radiation dosage compared to other structures. Greater changes to swallowing kinematics and timing were observed for pudding thick consistency than thin liquid. Increasing radiation dosage to swallowing-related structures is associated with reduced swallowing kinematics. However, not all structures are affected the same way, therefore organ sparing during treatment planning for IMRT needs to consider function rather than focusing on select muscles. Dose-response relationships should be investigated with a comprehensive set of swallowing structures to capture the holistic process of swallowing. | - |
dc.language | eng | - |
dc.publisher | Springer New York LLC. The Journal's web site is located at http://link.springer.de/link/service/journals/00455/ | - |
dc.relation.ispartof | Dysphagia | - |
dc.rights | This is a post-peer-review, pre-copyedit version of an article published in [insert journal title]. The final authenticated version is available online at: https://doi.org/[insert DOI] | - |
dc.rights | This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License. | - |
dc.subject | Nasopharyngeal carcinoma | - |
dc.subject | Head and neck cancer | - |
dc.subject | Intensity-modulated radiotherapy | - |
dc.subject | Radiation dosage | - |
dc.subject | Deglutition disorders | - |
dc.title | The relationships between radiation dosage and long-term swallowing kinematics and timing in nasopharyngeal carcinoma survivors | - |
dc.type | Article | - |
dc.identifier.email | Lee, VHF: vhflee@hku.hk | - |
dc.identifier.email | Chan, KMK: karencmk@hku.hk | - |
dc.identifier.email | Tsang, RKY: rkytsang@hku.hk | - |
dc.identifier.authority | Lee, VHF=rp00264 | - |
dc.identifier.authority | Chan, KMK=rp00893 | - |
dc.identifier.authority | Tsang, RKY=rp01386 | - |
dc.description.nature | published_or_final_version | - |
dc.identifier.doi | 10.1007/s00455-021-10311-6 | - |
dc.identifier.pmid | 33909131 | - |
dc.identifier.scopus | eid_2-s2.0-85105403010 | - |
dc.identifier.hkuros | 322428 | - |
dc.identifier.volume | Epub on 2021-04-28 | - |
dc.identifier.isi | WOS:000645089800002 | - |
dc.publisher.place | United States | - |