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Article: Optic disc and peripapillary vessel density measured with optical coherence tomography angiography and its associations in Chinese adults: a large population-based study

TitleOptic disc and peripapillary vessel density measured with optical coherence tomography angiography and its associations in Chinese adults: a large population-based study
Authors
Issue Date2021
PublisherBMJ Publishing Group. The Journal's web site is located at http://bjo.bmjjournals.com/
Citation
British Journal of Ophthalmology, 2021, p. 1-6 How to Cite?
AbstractPurpose To investigate the optic disc and peripapillary vessel density, as well as its ocular and systemic associations, in healthy eyes among adult Chinese population. Methods A population-based cross-sectional eye survey was conducted on Chinese adults residing in Hong Kong. 1891 eyes from 1891 participants who completed 4.5×4.5 mm optical coherence tomography angiography scans were recruited. Among the 1891 eyes, 404 were excluded due to low scan quality, optic disc or retinal disorders and non-Chinese ethnicity. The vessel densities (VDs) at nerve fibre layer plexus (NFLP) at both optic disc and peripapillary were collected for analysis. Multiple linear regression analysis was performed to determine the ocular and systemic associations of NFLP VD. Results The study included 1487 participants (men: 41.2%) with a mean age of 48.8±15.4 years. The mean NFLP VD of the whole en face image, inside disc and peripapillary region was 53.8%, 42.7% and 60.3%, respectively. In the multivariable model, decreased NFLP VDs were significantly associated with older age, male gender, longer axial length (AL) and lower Signal Strength Index. Conclusions This large population-based cross-sectional study provided quantitative data of optic disc and peripapillary NFLP VD which may serve as a normative reference for clinical use. Apart from age, gender and AL, the scan signal strength also should be taken into consideration during the assessment of NFLP VD.
Persistent Identifierhttp://hdl.handle.net/10722/300336
ISSN
2023 Impact Factor: 3.7
2023 SCImago Journal Rankings: 1.862
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorZhu, M-
dc.contributor.authorChoy, NKB-
dc.contributor.authorYou, QS-
dc.contributor.authorChan, JCH-
dc.contributor.authorNg, LKA-
dc.contributor.authorShih, KC-
dc.contributor.authorCheung, JJC-
dc.contributor.authorWong, KWJ-
dc.contributor.authorShum, JWH-
dc.contributor.authorNi, MY-
dc.contributor.authorLai, JSM-
dc.contributor.authorLeung, GM-
dc.contributor.authorWong, YHI-
dc.date.accessioned2021-06-04T08:41:29Z-
dc.date.available2021-06-04T08:41:29Z-
dc.date.issued2021-
dc.identifier.citationBritish Journal of Ophthalmology, 2021, p. 1-6-
dc.identifier.issn0007-1161-
dc.identifier.urihttp://hdl.handle.net/10722/300336-
dc.description.abstractPurpose To investigate the optic disc and peripapillary vessel density, as well as its ocular and systemic associations, in healthy eyes among adult Chinese population. Methods A population-based cross-sectional eye survey was conducted on Chinese adults residing in Hong Kong. 1891 eyes from 1891 participants who completed 4.5×4.5 mm optical coherence tomography angiography scans were recruited. Among the 1891 eyes, 404 were excluded due to low scan quality, optic disc or retinal disorders and non-Chinese ethnicity. The vessel densities (VDs) at nerve fibre layer plexus (NFLP) at both optic disc and peripapillary were collected for analysis. Multiple linear regression analysis was performed to determine the ocular and systemic associations of NFLP VD. Results The study included 1487 participants (men: 41.2%) with a mean age of 48.8±15.4 years. The mean NFLP VD of the whole en face image, inside disc and peripapillary region was 53.8%, 42.7% and 60.3%, respectively. In the multivariable model, decreased NFLP VDs were significantly associated with older age, male gender, longer axial length (AL) and lower Signal Strength Index. Conclusions This large population-based cross-sectional study provided quantitative data of optic disc and peripapillary NFLP VD which may serve as a normative reference for clinical use. Apart from age, gender and AL, the scan signal strength also should be taken into consideration during the assessment of NFLP VD.-
dc.languageeng-
dc.publisherBMJ Publishing Group. The Journal's web site is located at http://bjo.bmjjournals.com/-
dc.relation.ispartofBritish Journal of Ophthalmology-
dc.rightsBritish Journal of Ophthalmology. Copyright © BMJ Publishing Group.-
dc.rightsThis work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License-
dc.titleOptic disc and peripapillary vessel density measured with optical coherence tomography angiography and its associations in Chinese adults: a large population-based study-
dc.typeArticle-
dc.identifier.emailZhu, M: zhumm@hku.hk-
dc.identifier.emailChoy, NKB: bnkchoy@hku.hk-
dc.identifier.emailChan, JCH: jonochan@hku.hk-
dc.identifier.emailShih, KC: kcshih@hku.hk-
dc.identifier.emailWong, KWJ: jwongkw@hku.hk-
dc.identifier.emailNi, MY: nimy@hku.hk-
dc.identifier.emailLeung, GM: gmleung@hku.hk-
dc.identifier.authorityChoy, NKB=rp01795-
dc.identifier.authorityChan, JCH=rp02113-
dc.identifier.authorityNg, LKA=rp01842-
dc.identifier.authorityShih, KC=rp01374-
dc.identifier.authorityCheung, JJC=rp02219-
dc.identifier.authorityWong, KWJ=rp02294-
dc.identifier.authorityShum, JWH=rp01849-
dc.identifier.authorityNi, MY=rp01639-
dc.identifier.authorityLai, JSM=rp00295-
dc.identifier.authorityLeung, GM=rp00460-
dc.identifier.authorityWong, YHI=rp01467-
dc.description.naturelink_to_OA_fulltext-
dc.identifier.doi10.1136/bjophthalmol-2020-318199-
dc.identifier.scopuseid_2-s2.0-85106462772-
dc.identifier.hkuros322593-
dc.identifier.spage1-
dc.identifier.epage6-
dc.identifier.isiWOS:000726815700001-
dc.publisher.placeUnited Kingdom-

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