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- Publisher Website: 10.1007/s12687-021-00518-3
- Scopus: eid_2-s2.0-85105525625
- PMID: 33928521
- WOS: WOS:000645478000001
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Article: Baseline knowledge and receptiveness to genetic testing for hereditary breast and ovarian cancer syndromes in Chinese high-risk females
Title | Baseline knowledge and receptiveness to genetic testing for hereditary breast and ovarian cancer syndromes in Chinese high-risk females |
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Authors | |
Keywords | Hereditary breast cancer Genetic counselling BRCA1/2 Chinese Genetic testing |
Issue Date | 2021 |
Publisher | Springer. The Journal's web site is located at http://www.springer.com/biomed/human+genetics/journal/12687 |
Citation | Journal of Community Genetics, 2021, v. 12, p. 431-438 How to Cite? |
Abstract | Limited studies have examined the pre-counselling knowledge and attitudes of high-risk women on hereditary breast and ovarian cancer (HBOC) syndromes genetic screening in Asia Pacific regions, particularly among Chinese. After controlling cost, an intrinsic barrier to undertake such screening, comprehensive understanding of the baseline characteristics of this cohort towards HBOC genetic counselling and testing service (GT) could be sought. This study aimed at exploring the baseline knowledge, possible motivators, barriers, and decisional factors of undertaking such service. One hundred and forty-two Southern Hong Kong Chinese high-risk females (89.4% with cancer history; 10.6% were cancer-free at-risk family members) completed a questionnaire right before their pre-testing GT. Results showed that perceived benefits to self and family members with reference to cancer prevention are important decisional motivators. A sponsored cancer genetic testing service in this cohort was crucial as 71.3% would not have opted for self-financed screening. Pre-testing and post-testing counselling were essential, particularly for older and less educated high-risk individuals. More importantly, after thorough pre-counselling with Q&A session, the entire cohort in this study gave written consent to undertake GT. Moreover, those proven to be germline pathogenic variant carriers were willing to share the information with family members and successfully persuaded them to pursue GT. |
Persistent Identifier | http://hdl.handle.net/10722/301549 |
ISSN | 2023 Impact Factor: 1.5 2023 SCImago Journal Rankings: 0.643 |
PubMed Central ID | |
ISI Accession Number ID |
DC Field | Value | Language |
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dc.contributor.author | Chu, ATW | - |
dc.contributor.author | Tse, DMS | - |
dc.contributor.author | Suen, DTK | - |
dc.contributor.author | Kwong, A | - |
dc.date.accessioned | 2021-08-09T03:40:42Z | - |
dc.date.available | 2021-08-09T03:40:42Z | - |
dc.date.issued | 2021 | - |
dc.identifier.citation | Journal of Community Genetics, 2021, v. 12, p. 431-438 | - |
dc.identifier.issn | 1868-310X | - |
dc.identifier.uri | http://hdl.handle.net/10722/301549 | - |
dc.description.abstract | Limited studies have examined the pre-counselling knowledge and attitudes of high-risk women on hereditary breast and ovarian cancer (HBOC) syndromes genetic screening in Asia Pacific regions, particularly among Chinese. After controlling cost, an intrinsic barrier to undertake such screening, comprehensive understanding of the baseline characteristics of this cohort towards HBOC genetic counselling and testing service (GT) could be sought. This study aimed at exploring the baseline knowledge, possible motivators, barriers, and decisional factors of undertaking such service. One hundred and forty-two Southern Hong Kong Chinese high-risk females (89.4% with cancer history; 10.6% were cancer-free at-risk family members) completed a questionnaire right before their pre-testing GT. Results showed that perceived benefits to self and family members with reference to cancer prevention are important decisional motivators. A sponsored cancer genetic testing service in this cohort was crucial as 71.3% would not have opted for self-financed screening. Pre-testing and post-testing counselling were essential, particularly for older and less educated high-risk individuals. More importantly, after thorough pre-counselling with Q&A session, the entire cohort in this study gave written consent to undertake GT. Moreover, those proven to be germline pathogenic variant carriers were willing to share the information with family members and successfully persuaded them to pursue GT. | - |
dc.language | eng | - |
dc.publisher | Springer. The Journal's web site is located at http://www.springer.com/biomed/human+genetics/journal/12687 | - |
dc.relation.ispartof | Journal of Community Genetics | - |
dc.rights | Accepted Manuscript (AAM) This is a post-peer-review, pre-copyedit version of an article published in [insert journal title]. The final authenticated version is available online at: https://doi.org/[insert DOI] | - |
dc.subject | Hereditary breast cancer | - |
dc.subject | Genetic counselling | - |
dc.subject | BRCA1/2 | - |
dc.subject | Chinese | - |
dc.subject | Genetic testing | - |
dc.title | Baseline knowledge and receptiveness to genetic testing for hereditary breast and ovarian cancer syndromes in Chinese high-risk females | - |
dc.type | Article | - |
dc.identifier.email | Tse, DMS: d3siree@HKUCC-COM.hku.hk | - |
dc.identifier.email | Suen, DTK: suentkd@hku.hk | - |
dc.identifier.email | Kwong, A: avakwong@hku.hk | - |
dc.identifier.authority | Kwong, A=rp01734 | - |
dc.description.nature | link_to_OA_fulltext | - |
dc.identifier.doi | 10.1007/s12687-021-00518-3 | - |
dc.identifier.pmid | 33928521 | - |
dc.identifier.pmcid | PMC8241971 | - |
dc.identifier.scopus | eid_2-s2.0-85105525625 | - |
dc.identifier.hkuros | 324070 | - |
dc.identifier.volume | 12 | - |
dc.identifier.spage | 431 | - |
dc.identifier.epage | 438 | - |
dc.identifier.isi | WOS:000645478000001 | - |
dc.publisher.place | Germany | - |