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- Publisher Website: 10.1161/HYPERTENSIONAHA.120.16138
- Scopus: eid_2-s2.0-85100070678
- PMID: 33390054
- WOS: WOS:000639317900014
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Article: Blood Pressure and Risk of Cardiovascular Disease in UK Biobank: A Mendelian Randomization Study
Title | Blood Pressure and Risk of Cardiovascular Disease in UK Biobank: A Mendelian Randomization Study |
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Authors | |
Keywords | hypertension stroke cardiovascular diseases cohort studies odds ratio |
Issue Date | 2021 |
Publisher | American Heart Association, co-published with Lippincott Williams & Wilkins. The Journal's web site is located at http://hyper.ahajournals.org/ |
Citation | Hypertension, 2021, v. 77 n. 2, p. 367-375 How to Cite? |
Abstract | This study aims to evaluate the causal association of blood pressure (BP) with cardiovascular diseases (CVDs). Two-sample Mendelian randomization was performed using a large genome-wide association study (n=299 024) and the UK Biobank cohort (n=375 256). We identified 327 and 364 single-nucleotide polymorphisms strongly and independently associated with systolic BP and diastolic BP, respectively, as genetic instruments to assess the causal association of BP with total CVD, CVD mortality, and 14 cardiovascular conditions. Nonlinearity was examined with nonlinear instrumental variable assumptions. Genetically predicted BP was significantly positively associated with total CVD (systolic BP, per 10 mm Hg: odds ratio [OR], 1.32 [95% CI, 1.25–1.40]; diastolic BP, per 5 mm Hg: OR, 1.20 [95% CI, 1.15–1.26]). Similar positive causal associations were observed for 14 cardiovascular conditions including ischemic heart disease (systolic BP, per 10 mm Hg: OR, 1.33 [95% CI, 1.24–1.41]; diastolic BP, per 5 mm Hg: OR, 1.20 [95% CI, 1.14–1.27]) and stroke (systolic BP, per 10 mm Hg: OR, 1.35 [95% CI, 1.24–1.48]; diastolic BP, per 5 mm Hg: OR, 1.20 [95% CI, 1.12–1.28]). Nonlinearity Mendelian randomization test demonstrated linear causal association of BP with these outcomes. Consistent estimates were observed in sensitivity analyses, suggesting robustness of the associations and minimal horizontal pleiotropy. The linear positive causal association of BP and CVD was consistent with previous findings that lower BP is better, thus consolidating clinical knowledge on hypertension management in CVD risk reduction. |
Description | Bronze open access |
Persistent Identifier | http://hdl.handle.net/10722/301606 |
ISSN | 2023 Impact Factor: 6.9 2023 SCImago Journal Rankings: 2.827 |
ISI Accession Number ID |
DC Field | Value | Language |
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dc.contributor.author | Wan, EYF | - |
dc.contributor.author | Fung, WT | - |
dc.contributor.author | Schooling, CM | - |
dc.contributor.author | Au Yeung, SL | - |
dc.contributor.author | Kwok, MK | - |
dc.contributor.author | Yu, EYT | - |
dc.contributor.author | Wang, Y | - |
dc.contributor.author | Chan, EWY | - |
dc.contributor.author | Wong, ICK | - |
dc.contributor.author | Lam, CLK | - |
dc.date.accessioned | 2021-08-09T03:41:31Z | - |
dc.date.available | 2021-08-09T03:41:31Z | - |
dc.date.issued | 2021 | - |
dc.identifier.citation | Hypertension, 2021, v. 77 n. 2, p. 367-375 | - |
dc.identifier.issn | 0194-911X | - |
dc.identifier.uri | http://hdl.handle.net/10722/301606 | - |
dc.description | Bronze open access | - |
dc.description.abstract | This study aims to evaluate the causal association of blood pressure (BP) with cardiovascular diseases (CVDs). Two-sample Mendelian randomization was performed using a large genome-wide association study (n=299 024) and the UK Biobank cohort (n=375 256). We identified 327 and 364 single-nucleotide polymorphisms strongly and independently associated with systolic BP and diastolic BP, respectively, as genetic instruments to assess the causal association of BP with total CVD, CVD mortality, and 14 cardiovascular conditions. Nonlinearity was examined with nonlinear instrumental variable assumptions. Genetically predicted BP was significantly positively associated with total CVD (systolic BP, per 10 mm Hg: odds ratio [OR], 1.32 [95% CI, 1.25–1.40]; diastolic BP, per 5 mm Hg: OR, 1.20 [95% CI, 1.15–1.26]). Similar positive causal associations were observed for 14 cardiovascular conditions including ischemic heart disease (systolic BP, per 10 mm Hg: OR, 1.33 [95% CI, 1.24–1.41]; diastolic BP, per 5 mm Hg: OR, 1.20 [95% CI, 1.14–1.27]) and stroke (systolic BP, per 10 mm Hg: OR, 1.35 [95% CI, 1.24–1.48]; diastolic BP, per 5 mm Hg: OR, 1.20 [95% CI, 1.12–1.28]). Nonlinearity Mendelian randomization test demonstrated linear causal association of BP with these outcomes. Consistent estimates were observed in sensitivity analyses, suggesting robustness of the associations and minimal horizontal pleiotropy. The linear positive causal association of BP and CVD was consistent with previous findings that lower BP is better, thus consolidating clinical knowledge on hypertension management in CVD risk reduction. | - |
dc.language | eng | - |
dc.publisher | American Heart Association, co-published with Lippincott Williams & Wilkins. The Journal's web site is located at http://hyper.ahajournals.org/ | - |
dc.relation.ispartof | Hypertension | - |
dc.subject | hypertension | - |
dc.subject | stroke | - |
dc.subject | cardiovascular diseases | - |
dc.subject | cohort studies | - |
dc.subject | odds ratio | - |
dc.title | Blood Pressure and Risk of Cardiovascular Disease in UK Biobank: A Mendelian Randomization Study | - |
dc.type | Article | - |
dc.identifier.email | Wan, EYF: yfwan@hku.hk | - |
dc.identifier.email | Fung, WT: japiofwt@hku.hk | - |
dc.identifier.email | Schooling, CM: cms1@hkucc.hku.hk | - |
dc.identifier.email | Au Yeung, SL: ayslryan@hku.hk | - |
dc.identifier.email | Kwok, MK: maggiek@hku.hk | - |
dc.identifier.email | Yu, EYT: ytyu@hku.hk | - |
dc.identifier.email | Chan, EWY: ewchan@hku.hk | - |
dc.identifier.email | Wong, ICK: wongick@hku.hk | - |
dc.identifier.email | Lam, CLK: clklam@hku.hk | - |
dc.identifier.authority | Wan, EYF=rp02518 | - |
dc.identifier.authority | Schooling, CM=rp00504 | - |
dc.identifier.authority | Au Yeung, SL=rp02224 | - |
dc.identifier.authority | Kwok, MK=rp02051 | - |
dc.identifier.authority | Yu, EYT=rp01693 | - |
dc.identifier.authority | Chan, EWY=rp01587 | - |
dc.identifier.authority | Wong, ICK=rp01480 | - |
dc.identifier.authority | Lam, CLK=rp00350 | - |
dc.description.nature | link_to_OA_fulltext | - |
dc.identifier.doi | 10.1161/HYPERTENSIONAHA.120.16138 | - |
dc.identifier.pmid | 33390054 | - |
dc.identifier.scopus | eid_2-s2.0-85100070678 | - |
dc.identifier.hkuros | 323934 | - |
dc.identifier.volume | 77 | - |
dc.identifier.issue | 2 | - |
dc.identifier.spage | 367 | - |
dc.identifier.epage | 375 | - |
dc.identifier.isi | WOS:000639317900014 | - |
dc.publisher.place | United States | - |