File Download

There are no files associated with this item.

  Links for fulltext
     (May Require Subscription)

Article: Blood Pressure and Risk of Cardiovascular Disease in UK Biobank: A Mendelian Randomization Study

TitleBlood Pressure and Risk of Cardiovascular Disease in UK Biobank: A Mendelian Randomization Study
Authors
Keywordshypertension
stroke
cardiovascular diseases
cohort studies
odds ratio
Issue Date2021
PublisherAmerican Heart Association, co-published with Lippincott Williams & Wilkins. The Journal's web site is located at http://hyper.ahajournals.org/
Citation
Hypertension, 2021, v. 77 n. 2, p. 367-375 How to Cite?
AbstractThis study aims to evaluate the causal association of blood pressure (BP) with cardiovascular diseases (CVDs). Two-sample Mendelian randomization was performed using a large genome-wide association study (n=299 024) and the UK Biobank cohort (n=375 256). We identified 327 and 364 single-nucleotide polymorphisms strongly and independently associated with systolic BP and diastolic BP, respectively, as genetic instruments to assess the causal association of BP with total CVD, CVD mortality, and 14 cardiovascular conditions. Nonlinearity was examined with nonlinear instrumental variable assumptions. Genetically predicted BP was significantly positively associated with total CVD (systolic BP, per 10 mm Hg: odds ratio [OR], 1.32 [95% CI, 1.25–1.40]; diastolic BP, per 5 mm Hg: OR, 1.20 [95% CI, 1.15–1.26]). Similar positive causal associations were observed for 14 cardiovascular conditions including ischemic heart disease (systolic BP, per 10 mm Hg: OR, 1.33 [95% CI, 1.24–1.41]; diastolic BP, per 5 mm Hg: OR, 1.20 [95% CI, 1.14–1.27]) and stroke (systolic BP, per 10 mm Hg: OR, 1.35 [95% CI, 1.24–1.48]; diastolic BP, per 5 mm Hg: OR, 1.20 [95% CI, 1.12–1.28]). Nonlinearity Mendelian randomization test demonstrated linear causal association of BP with these outcomes. Consistent estimates were observed in sensitivity analyses, suggesting robustness of the associations and minimal horizontal pleiotropy. The linear positive causal association of BP and CVD was consistent with previous findings that lower BP is better, thus consolidating clinical knowledge on hypertension management in CVD risk reduction.
DescriptionBronze open access
Persistent Identifierhttp://hdl.handle.net/10722/301606
ISSN
2021 Impact Factor: 9.897
2020 SCImago Journal Rankings: 2.986
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorWan, EYF-
dc.contributor.authorFung, WT-
dc.contributor.authorSchooling, CM-
dc.contributor.authorAu Yeung, SL-
dc.contributor.authorKwok, MK-
dc.contributor.authorYu, EYT-
dc.contributor.authorWang, Y-
dc.contributor.authorChan, EWY-
dc.contributor.authorWong, ICK-
dc.contributor.authorLam, CLK-
dc.date.accessioned2021-08-09T03:41:31Z-
dc.date.available2021-08-09T03:41:31Z-
dc.date.issued2021-
dc.identifier.citationHypertension, 2021, v. 77 n. 2, p. 367-375-
dc.identifier.issn0194-911X-
dc.identifier.urihttp://hdl.handle.net/10722/301606-
dc.descriptionBronze open access-
dc.description.abstractThis study aims to evaluate the causal association of blood pressure (BP) with cardiovascular diseases (CVDs). Two-sample Mendelian randomization was performed using a large genome-wide association study (n=299 024) and the UK Biobank cohort (n=375 256). We identified 327 and 364 single-nucleotide polymorphisms strongly and independently associated with systolic BP and diastolic BP, respectively, as genetic instruments to assess the causal association of BP with total CVD, CVD mortality, and 14 cardiovascular conditions. Nonlinearity was examined with nonlinear instrumental variable assumptions. Genetically predicted BP was significantly positively associated with total CVD (systolic BP, per 10 mm Hg: odds ratio [OR], 1.32 [95% CI, 1.25–1.40]; diastolic BP, per 5 mm Hg: OR, 1.20 [95% CI, 1.15–1.26]). Similar positive causal associations were observed for 14 cardiovascular conditions including ischemic heart disease (systolic BP, per 10 mm Hg: OR, 1.33 [95% CI, 1.24–1.41]; diastolic BP, per 5 mm Hg: OR, 1.20 [95% CI, 1.14–1.27]) and stroke (systolic BP, per 10 mm Hg: OR, 1.35 [95% CI, 1.24–1.48]; diastolic BP, per 5 mm Hg: OR, 1.20 [95% CI, 1.12–1.28]). Nonlinearity Mendelian randomization test demonstrated linear causal association of BP with these outcomes. Consistent estimates were observed in sensitivity analyses, suggesting robustness of the associations and minimal horizontal pleiotropy. The linear positive causal association of BP and CVD was consistent with previous findings that lower BP is better, thus consolidating clinical knowledge on hypertension management in CVD risk reduction.-
dc.languageeng-
dc.publisherAmerican Heart Association, co-published with Lippincott Williams & Wilkins. The Journal's web site is located at http://hyper.ahajournals.org/-
dc.relation.ispartofHypertension-
dc.subjecthypertension-
dc.subjectstroke-
dc.subjectcardiovascular diseases-
dc.subjectcohort studies-
dc.subjectodds ratio-
dc.titleBlood Pressure and Risk of Cardiovascular Disease in UK Biobank: A Mendelian Randomization Study-
dc.typeArticle-
dc.identifier.emailWan, EYF: yfwan@hku.hk-
dc.identifier.emailFung, WT: japiofwt@hku.hk-
dc.identifier.emailSchooling, CM: cms1@hkucc.hku.hk-
dc.identifier.emailAu Yeung, SL: ayslryan@hku.hk-
dc.identifier.emailKwok, MK: maggiek@hku.hk-
dc.identifier.emailYu, EYT: ytyu@hku.hk-
dc.identifier.emailChan, EWY: ewchan@hku.hk-
dc.identifier.emailWong, ICK: wongick@hku.hk-
dc.identifier.emailLam, CLK: clklam@hku.hk-
dc.identifier.authorityWan, EYF=rp02518-
dc.identifier.authoritySchooling, CM=rp00504-
dc.identifier.authorityAu Yeung, SL=rp02224-
dc.identifier.authorityKwok, MK=rp02051-
dc.identifier.authorityYu, EYT=rp01693-
dc.identifier.authorityChan, EWY=rp01587-
dc.identifier.authorityWong, ICK=rp01480-
dc.identifier.authorityLam, CLK=rp00350-
dc.description.naturelink_to_OA_fulltext-
dc.identifier.doi10.1161/HYPERTENSIONAHA.120.16138-
dc.identifier.pmid33390054-
dc.identifier.scopuseid_2-s2.0-85100070678-
dc.identifier.hkuros323934-
dc.identifier.volume77-
dc.identifier.issue2-
dc.identifier.spage367-
dc.identifier.epage375-
dc.identifier.isiWOS:000639317900014-
dc.publisher.placeUnited States-

Export via OAI-PMH Interface in XML Formats


OR


Export to Other Non-XML Formats