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Article: Breast cancer risk after age 60 among BRCA1 and BRCA2 mutation carriers

TitleBreast cancer risk after age 60 among BRCA1 and BRCA2 mutation carriers
Authors
KeywordsBRCA1
BRCA2
Incidence
Prospective
Issue Date2021
PublisherSpringer New York LLC. The Journal's web site is located at http://springerlink.metapress.com/openurl.asp?genre=journal&issn=0167-6806
Citation
Breast Cancer Research and Treatment, 2021, v. 187, p. 515-523 How to Cite?
AbstractPurpose: It is not known whether the risk of breast cancer among BRCA1 and BRCA2 mutation carriers after age 60 is high enough to justify intensive screening or prophylactic surgery. Thus, we conducted a prospective analysis of breast cancer risk in BRCA1 and BRCA2 mutation carriers from age 60 until age 80. Methods: Subjects had no history of cancer and both breasts intact at age 60 (n = 699). Women were followed until a breast cancer diagnosis, prophylactic bilateral mastectomy or death. We calculated the annual cancer rate and cumulative incidence of breast cancer (invasive and in situ) from age 60 to age 80. We assessed the associations between hormone replacement therapy, family history of breast cancer and bilateral oophorectomy and breast cancer risk. Results: Over a mean follow-up of 7.9 years, 61 invasive and 20 in situ breast cancers were diagnosed in the cohort. The mean annual rate of invasive breast cancer was 1.8% for BRCA1 mutation carriers and 1.7% for BRCA2 mutation carriers. The cumulative risk of invasive breast cancer from age 60 to 80 was 20.1% for women with a BRCA1 mutation and was 17.3% for women with a BRCA2 mutation. Hormone replacement therapy, family history and oophorectomy were not associated with breast cancer risk. Conclusions: Findings from this large prospective study indicate that the risk of developing breast cancer remains high after age 60 in both BRCA1 and BRCA2 mutation carriers. These findings warrant further evaluation of the role of breast cancer screening in older mutation carriers.
Persistent Identifierhttp://hdl.handle.net/10722/301686
ISSN
2021 Impact Factor: 4.624
2020 SCImago Journal Rankings: 1.908
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorStjepanovic, N-
dc.contributor.authorLubinski, J-
dc.contributor.authorMoller, P-
dc.contributor.authorRandall Armel, S-
dc.contributor.authorFoulkes, WD-
dc.contributor.authorTung, N-
dc.contributor.authorNeuhausen, SL-
dc.contributor.authorKotsopoulos, J-
dc.contributor.authorSun, P-
dc.contributor.authorSun, S-
dc.contributor.authorEisen, A-
dc.contributor.authorNarod, SA-
dc.contributor.authorSentER, L-
dc.contributor.authorCouch, CEF-
dc.contributor.authorFruscio, R-
dc.contributor.authorWeitzel, JN-
dc.contributor.authorOlopade, O-
dc.contributor.authorSinger, CF-
dc.contributor.authorPal, T-
dc.contributor.authorHuzarski, T-
dc.contributor.authorCybulski, C-
dc.contributor.authorSweet, K-
dc.contributor.authorZakalik, D-
dc.contributor.authorWood, M-
dc.contributor.authorMcKinnon, W-
dc.contributor.authorElser, C-
dc.contributor.authorWiesner, G-
dc.contributor.authorFriedman, E-
dc.contributor.authorMeschino, W-
dc.contributor.authorSnyder, C-
dc.contributor.authorMetcalfe, K-
dc.contributor.authorPoll, A-
dc.contributor.authorWarner, E-
dc.contributor.authorKim, R-
dc.contributor.authorDemsky, R-
dc.contributor.authorAinsworth, P-
dc.contributor.authorSteele, L-
dc.contributor.authorSaal, H-
dc.contributor.authorSerfas, K-
dc.contributor.authorPanchal, S-
dc.contributor.authorCullinane, CA-
dc.contributor.authorReilly, RE-
dc.contributor.authorBlum, JL-
dc.contributor.authorKwong, A-
dc.contributor.authorRayson, D-
dc.contributor.authorCajal, TR-
dc.contributor.authorDungan, J-
dc.contributor.authorYerushalmI, R-
dc.contributor.authorGinsburg, O-
dc.contributor.authorSchraeder, I-
dc.contributor.authorCohen, S-
dc.contributor.authorLemire, E-
dc.contributor.authorZovato, S-
dc.contributor.authorRastelli, A-
dc.contributor.authorGronwald, J-
dc.contributor.authorMcCuaig, J-
dc.contributor.authorKarlan, B-
dc.contributor.authorBordeleau, L-
dc.date.accessioned2021-08-09T03:42:44Z-
dc.date.available2021-08-09T03:42:44Z-
dc.date.issued2021-
dc.identifier.citationBreast Cancer Research and Treatment, 2021, v. 187, p. 515-523-
dc.identifier.issn0167-6806-
dc.identifier.urihttp://hdl.handle.net/10722/301686-
dc.description.abstractPurpose: It is not known whether the risk of breast cancer among BRCA1 and BRCA2 mutation carriers after age 60 is high enough to justify intensive screening or prophylactic surgery. Thus, we conducted a prospective analysis of breast cancer risk in BRCA1 and BRCA2 mutation carriers from age 60 until age 80. Methods: Subjects had no history of cancer and both breasts intact at age 60 (n = 699). Women were followed until a breast cancer diagnosis, prophylactic bilateral mastectomy or death. We calculated the annual cancer rate and cumulative incidence of breast cancer (invasive and in situ) from age 60 to age 80. We assessed the associations between hormone replacement therapy, family history of breast cancer and bilateral oophorectomy and breast cancer risk. Results: Over a mean follow-up of 7.9 years, 61 invasive and 20 in situ breast cancers were diagnosed in the cohort. The mean annual rate of invasive breast cancer was 1.8% for BRCA1 mutation carriers and 1.7% for BRCA2 mutation carriers. The cumulative risk of invasive breast cancer from age 60 to 80 was 20.1% for women with a BRCA1 mutation and was 17.3% for women with a BRCA2 mutation. Hormone replacement therapy, family history and oophorectomy were not associated with breast cancer risk. Conclusions: Findings from this large prospective study indicate that the risk of developing breast cancer remains high after age 60 in both BRCA1 and BRCA2 mutation carriers. These findings warrant further evaluation of the role of breast cancer screening in older mutation carriers.-
dc.languageeng-
dc.publisherSpringer New York LLC. The Journal's web site is located at http://springerlink.metapress.com/openurl.asp?genre=journal&issn=0167-6806-
dc.relation.ispartofBreast Cancer Research and Treatment-
dc.rightsThis is a post-peer-review, pre-copyedit version of an article published in [insert journal title]. The final authenticated version is available online at: https://doi.org/[insert DOI]-
dc.subjectBRCA1-
dc.subjectBRCA2-
dc.subjectIncidence-
dc.subjectProspective-
dc.titleBreast cancer risk after age 60 among BRCA1 and BRCA2 mutation carriers-
dc.typeArticle-
dc.identifier.emailKwong, A: avakwong@hku.hk-
dc.identifier.authorityKwong, A=rp01734-
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1007/s10549-020-06072-9-
dc.identifier.scopuseid_2-s2.0-85099351095-
dc.identifier.hkuros324055-
dc.identifier.volume187-
dc.identifier.spage515-
dc.identifier.epage523-
dc.identifier.isiWOS:000606739300002-
dc.publisher.placeUnited States-

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