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Article: Virus load and virus shedding of SARS-CoV-2 and their impact on patient outcomes

TitleVirus load and virus shedding of SARS-CoV-2 and their impact on patient outcomes
Authors
KeywordsCOVID-19
Virus shedding
Viral load
Patient outcome
China
Issue Date2020
PublisherBaishideng Publishing Group Co., Limited. The Journal's web site is located at http://www.wjgnet.com/2307-8960/about.htm
Citation
World Journal of Clinical Cases, 2020, v. 8 n. 24, p. 6252-6263 How to Cite?
AbstractBACKGROUND Understanding a virus shedding patterns in body fluids/secretions is important to determine the samples to be used for diagnosis and to formulate infection control measures. AIM To investigate the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) shedding patterns and its risk factors. METHODS All laboratory-confirmed coronavirus disease 2019 patients with complete medical records admitted to the Shenzhen Third People’s Hospital from January 28, 2020 to March 8, 2020 were included. Among 145 patients (54.5% males; median age, 46.1 years), three (2.1%) died. The bronco-alveolar lavage fluid (BALF) had the highest virus load compared with the other samples. The viral load peaked at admission (3.3 × 108 copies) and sharply decreased 10 d after admission. RESULTS The viral load was associated with prolonged intensive care unit (ICU) duration. Patients in the ICU had significantly longer shedding time compared to those in the wards (P < 0.0001). Age > 60 years [hazard ratio (HR) = 0.6; 95% confidence interval (CI): 0.4-0.9] was an independent risk factor for SARS-CoV-2 shedding, while chloroquine (HR = 22.8; 95%CI: 2.3-224.6) was a protective factor. CONCLUSION BALF had the highest SARS-CoV-2 load. Elderly patients had higher virus loads, which was associated with a prolonged ICU stay. Chloroquine was associated with shorter shedding duration and increased the chance of viral negativity.
Persistent Identifierhttp://hdl.handle.net/10722/301694
ISSN
2023 Impact Factor: 1.0
PubMed Central ID
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorChen, PF-
dc.contributor.authorYu, XX-
dc.contributor.authorLiu, YP-
dc.contributor.authorRen, D-
dc.contributor.authorShen, M-
dc.contributor.authorHuang, BS-
dc.contributor.authorGao, JL-
dc.contributor.authorHuang, ZY-
dc.contributor.authorWu, M-
dc.contributor.authorWang, WY-
dc.contributor.authorChen, L-
dc.contributor.authorShi, X-
dc.contributor.authorWang, ZQ-
dc.contributor.authorLiu, Y-
dc.contributor.authorLiu, L-
dc.contributor.authorLiu, Y-
dc.date.accessioned2021-08-09T03:42:51Z-
dc.date.available2021-08-09T03:42:51Z-
dc.date.issued2020-
dc.identifier.citationWorld Journal of Clinical Cases, 2020, v. 8 n. 24, p. 6252-6263-
dc.identifier.issn2307-8960-
dc.identifier.urihttp://hdl.handle.net/10722/301694-
dc.description.abstractBACKGROUND Understanding a virus shedding patterns in body fluids/secretions is important to determine the samples to be used for diagnosis and to formulate infection control measures. AIM To investigate the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) shedding patterns and its risk factors. METHODS All laboratory-confirmed coronavirus disease 2019 patients with complete medical records admitted to the Shenzhen Third People’s Hospital from January 28, 2020 to March 8, 2020 were included. Among 145 patients (54.5% males; median age, 46.1 years), three (2.1%) died. The bronco-alveolar lavage fluid (BALF) had the highest virus load compared with the other samples. The viral load peaked at admission (3.3 × 108 copies) and sharply decreased 10 d after admission. RESULTS The viral load was associated with prolonged intensive care unit (ICU) duration. Patients in the ICU had significantly longer shedding time compared to those in the wards (P < 0.0001). Age > 60 years [hazard ratio (HR) = 0.6; 95% confidence interval (CI): 0.4-0.9] was an independent risk factor for SARS-CoV-2 shedding, while chloroquine (HR = 22.8; 95%CI: 2.3-224.6) was a protective factor. CONCLUSION BALF had the highest SARS-CoV-2 load. Elderly patients had higher virus loads, which was associated with a prolonged ICU stay. Chloroquine was associated with shorter shedding duration and increased the chance of viral negativity.-
dc.languageeng-
dc.publisherBaishideng Publishing Group Co., Limited. The Journal's web site is located at http://www.wjgnet.com/2307-8960/about.htm-
dc.relation.ispartofWorld Journal of Clinical Cases-
dc.rightsThis work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.-
dc.subjectCOVID-19-
dc.subjectVirus shedding-
dc.subjectViral load-
dc.subjectPatient outcome-
dc.subjectChina-
dc.titleVirus load and virus shedding of SARS-CoV-2 and their impact on patient outcomes-
dc.typeArticle-
dc.identifier.emailGao, JL: galeng@hku.hk-
dc.identifier.authorityRan, M=rp01788-
dc.description.naturepublished_or_final_version-
dc.identifier.doi10.12998/wjcc.v8.i24.6252-
dc.identifier.pmid33392306-
dc.identifier.pmcidPMC7760445-
dc.identifier.scopuseid_2-s2.0-85098713677-
dc.identifier.hkuros324116-
dc.identifier.hkuros324113-
dc.identifier.volume8-
dc.identifier.issue24-
dc.identifier.spage6252-
dc.identifier.epage6263-
dc.identifier.isiWOS:000603646900004-
dc.publisher.placeUnited States-

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