File Download
  Links for fulltext
     (May Require Subscription)
Supplementary

Article: Absence of Vaccine-enhanced Disease With Unexpected Positive Protection Against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) by Inactivated Vaccine Given Within 3 Days of Virus Challenge in Syrian Hamster Model

TitleAbsence of Vaccine-enhanced Disease With Unexpected Positive Protection Against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) by Inactivated Vaccine Given Within 3 Days of Virus Challenge in Syrian Hamster Model
Authors
Keywordscoronavirus
COVID-19
hamster
SARS-CoV-2
vaccine
Issue Date2021
PublisherOxford University Press, published in association with Clinical Infectious Diseases. The Journal's web site is located at http://www.oxfordjournals.org/our_journals/cid/
Citation
Clinical Infectious Diseases, 2021, v. 73 n. 3, p. e719-e734 How to Cite?
AbstractBackground: Mass vaccination against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is ongoing amidst widespread transmission during the coronavirus disease-2019 (COVID-19) pandemic. Disease phenotypes of SARS-CoV-2 exposure occurring around the time of vaccine administration have not been described. Methods: Two-dose (14 days apart) vaccination regimen with formalin-inactivated whole virion SARS-CoV-2 in golden Syrian hamster model was established. To investigate the disease phenotypes of a 1-dose regimen given 3 days prior (D-3), 1 (D1) or 2 (D2) days after, or on the day (D0) of virus challenge, we monitored the serial clinical severity, tissue histopathology, virus burden, and antibody response of the vaccinated hamsters. Results: The 1-dose vaccinated hamsters had significantly lower clinical disease severity score, body weight loss, lung histology score, nucleocapsid protein expression in lung, infectious virus titers in the lung and nasal turbinate, inflammatory changes in intestines, and a higher serum neutralizing antibody or IgG titer against the spike receptor-binding domain or nucleocapsid protein when compared to unvaccinated controls. These improvements were particularly noticeable in D-3, but also in D0, D1, and even D2 vaccinated hamsters to varying degrees. No increased eosinophilic infiltration was found in the nasal turbinate, lung, and intestine after virus challenge. Significantly higher serum titer of fluorescent foci microneutralization inhibition antibody was detected in D1 and D2 vaccinated hamsters at day 4 post-challenge compared to controls despite undetectable neutralizing antibody titer. Conclusions: Vaccination just before or soon after exposure to SARS-CoV-2 does not worsen disease phenotypes and may even ameliorate infection.
Descriptioneid_2-s2.0-85103163688
Persistent Identifierhttp://hdl.handle.net/10722/303983
ISSN
2023 Impact Factor: 8.2
2023 SCImago Journal Rankings: 3.308
PubMed Central ID
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorLi, C-
dc.contributor.authorChen, YX-
dc.contributor.authorLiu, FF-
dc.contributor.authorLee, ACY-
dc.contributor.authorZhao, Y-
dc.contributor.authorYe, ZH-
dc.contributor.authorCai, JP-
dc.contributor.authorChu, H-
dc.contributor.authorZhang, RQ-
dc.contributor.authorChan, KH-
dc.contributor.authorChiu, KHY-
dc.contributor.authorLung, DC-
dc.contributor.authorSridhar, S-
dc.contributor.authorHung, IFN-
dc.contributor.authorTo, KKW-
dc.contributor.authorZhang, AJX-
dc.contributor.authorChan, JFW-
dc.contributor.authorYuen, KY-
dc.date.accessioned2021-09-23T08:53:34Z-
dc.date.available2021-09-23T08:53:34Z-
dc.date.issued2021-
dc.identifier.citationClinical Infectious Diseases, 2021, v. 73 n. 3, p. e719-e734-
dc.identifier.issn1058-4838-
dc.identifier.urihttp://hdl.handle.net/10722/303983-
dc.descriptioneid_2-s2.0-85103163688-
dc.description.abstractBackground: Mass vaccination against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is ongoing amidst widespread transmission during the coronavirus disease-2019 (COVID-19) pandemic. Disease phenotypes of SARS-CoV-2 exposure occurring around the time of vaccine administration have not been described. Methods: Two-dose (14 days apart) vaccination regimen with formalin-inactivated whole virion SARS-CoV-2 in golden Syrian hamster model was established. To investigate the disease phenotypes of a 1-dose regimen given 3 days prior (D-3), 1 (D1) or 2 (D2) days after, or on the day (D0) of virus challenge, we monitored the serial clinical severity, tissue histopathology, virus burden, and antibody response of the vaccinated hamsters. Results: The 1-dose vaccinated hamsters had significantly lower clinical disease severity score, body weight loss, lung histology score, nucleocapsid protein expression in lung, infectious virus titers in the lung and nasal turbinate, inflammatory changes in intestines, and a higher serum neutralizing antibody or IgG titer against the spike receptor-binding domain or nucleocapsid protein when compared to unvaccinated controls. These improvements were particularly noticeable in D-3, but also in D0, D1, and even D2 vaccinated hamsters to varying degrees. No increased eosinophilic infiltration was found in the nasal turbinate, lung, and intestine after virus challenge. Significantly higher serum titer of fluorescent foci microneutralization inhibition antibody was detected in D1 and D2 vaccinated hamsters at day 4 post-challenge compared to controls despite undetectable neutralizing antibody titer. Conclusions: Vaccination just before or soon after exposure to SARS-CoV-2 does not worsen disease phenotypes and may even ameliorate infection.-
dc.languageeng-
dc.publisherOxford University Press, published in association with Clinical Infectious Diseases. The Journal's web site is located at http://www.oxfordjournals.org/our_journals/cid/-
dc.relation.ispartofClinical Infectious Diseases-
dc.rightsThis work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.-
dc.subjectcoronavirus-
dc.subjectCOVID-19-
dc.subjecthamster-
dc.subjectSARS-CoV-2-
dc.subjectvaccine-
dc.titleAbsence of Vaccine-enhanced Disease With Unexpected Positive Protection Against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) by Inactivated Vaccine Given Within 3 Days of Virus Challenge in Syrian Hamster Model-
dc.typeArticle-
dc.identifier.emailLi, C: canlee@hku.hk-
dc.identifier.emailLiu, FF: liuts89@HKUCC-COM.hku.hk-
dc.identifier.emailLee, ACY: cyalee@hku.hk-
dc.identifier.emailZhao, Y: zoezhao7@hku.hk-
dc.identifier.emailYe, ZH: yezhh7@hku.hk-
dc.identifier.emailCai, JP: caijuice@hku.hk-
dc.identifier.emailChu, H: hinchu@hku.hk-
dc.identifier.emailZhang, RQ: zhangrq@hku.hk-
dc.identifier.emailChan, KH: chankh2@hkucc.hku.hk-
dc.identifier.emailChiu, KHY: hychiu14@hku.hk-
dc.identifier.emailSridhar, S: sid8998@hku.hk-
dc.identifier.emailHung, IFN: ivanhung@hkucc.hku.hk-
dc.identifier.emailTo, KKW: kelvinto@hku.hk-
dc.identifier.emailZhang, AJX: zhangajx@hkucc.hku.hk-
dc.identifier.emailChan, JFW: jfwchan@hku.hk-
dc.identifier.emailYuen, KY: kyyuen@hkucc.hku.hk-
dc.identifier.authorityChu, H=rp02125-
dc.identifier.authorityChan, KH=rp01921-
dc.identifier.authoritySridhar, S=rp02249-
dc.identifier.authorityHung, IFN=rp00508-
dc.identifier.authorityTo, KKW=rp01384-
dc.identifier.authorityZhang, AJX=rp00413-
dc.identifier.authorityChan, JFW=rp01736-
dc.identifier.authorityYuen, KY=rp00366-
dc.description.naturepublished_or_final_version-
dc.identifier.doi10.1093/cid/ciab083-
dc.identifier.pmid33515458-
dc.identifier.pmcidPMC7929057-
dc.identifier.scopuseid_2-s2.0-85103163688-
dc.identifier.hkuros325636-
dc.identifier.volume73-
dc.identifier.issue3-
dc.identifier.spagee719-
dc.identifier.epagee734-
dc.identifier.isiWOS:000700007300070-
dc.publisher.placeUnited States-

Export via OAI-PMH Interface in XML Formats


OR


Export to Other Non-XML Formats