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- Publisher Website: 10.1016/j.bioactmat.2021.08.026
- Scopus: eid_2-s2.0-85119170938
- PMID: 34901555
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Article: Soft overcomes the hard: Flexible materials adapt to cell adhesion to promote cell mechanotransduction
Title | Soft overcomes the hard: Flexible materials adapt to cell adhesion to promote cell mechanotransduction |
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Authors | |
Keywords | Cell Mechanotransduction Intracellular force Biomaterials Soft materials |
Issue Date | 2022 |
Publisher | Elsevier B.V. on behalf of KeAi Communications Co. Ltd. The Journal's web site is located at http://www.sciencedirect.com/science/journal/2452199X |
Citation | Bioactive Materials, 2022, v. 10, p. 397-404 How to Cite? |
Abstract | Cell behaviors and functions show distinct contrast in different mechanical microenvironment. Numerous materials with varied rigidity have been developed to mimic the interactions between cells and their surroundings. However, the conventional static materials cannot fully capture the dynamic alterations at the bio-interface, especially for the molecular motion and the local mechanical changes in nanoscale. As an alternative, flexible materials have great potential to sense and adapt to mechanical changes in such complex microenvironment. The flexible materials could promote the cellular mechanosensing by dynamically adjusting their local mechanics, topography and ligand presentation to adapt to intracellular force generation. This process enables the cells to exhibit comparable or even higher level of mechanotransduction and the downstream ‘hard’ phenotypes compared to the conventional stiff or rigid ones. Here, we highlight the relevant studies regarding the development of such adaptive materials to mediate cell behaviors across the rigidity limitation on soft substrates. The concept of ‘soft overcomes the hard’ will guide the future development and application of biological materials. |
Persistent Identifier | http://hdl.handle.net/10722/305817 |
ISSN | 2023 Impact Factor: 18.0 2023 SCImago Journal Rankings: 3.466 |
PubMed Central ID | |
ISI Accession Number ID |
DC Field | Value | Language |
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dc.contributor.author | Sun, Q | - |
dc.contributor.author | Hou, Y | - |
dc.contributor.author | Chu, Z | - |
dc.contributor.author | Wei, Q | - |
dc.date.accessioned | 2021-10-20T10:14:44Z | - |
dc.date.available | 2021-10-20T10:14:44Z | - |
dc.date.issued | 2022 | - |
dc.identifier.citation | Bioactive Materials, 2022, v. 10, p. 397-404 | - |
dc.identifier.issn | 2452-199X | - |
dc.identifier.uri | http://hdl.handle.net/10722/305817 | - |
dc.description.abstract | Cell behaviors and functions show distinct contrast in different mechanical microenvironment. Numerous materials with varied rigidity have been developed to mimic the interactions between cells and their surroundings. However, the conventional static materials cannot fully capture the dynamic alterations at the bio-interface, especially for the molecular motion and the local mechanical changes in nanoscale. As an alternative, flexible materials have great potential to sense and adapt to mechanical changes in such complex microenvironment. The flexible materials could promote the cellular mechanosensing by dynamically adjusting their local mechanics, topography and ligand presentation to adapt to intracellular force generation. This process enables the cells to exhibit comparable or even higher level of mechanotransduction and the downstream ‘hard’ phenotypes compared to the conventional stiff or rigid ones. Here, we highlight the relevant studies regarding the development of such adaptive materials to mediate cell behaviors across the rigidity limitation on soft substrates. The concept of ‘soft overcomes the hard’ will guide the future development and application of biological materials. | - |
dc.language | eng | - |
dc.publisher | Elsevier B.V. on behalf of KeAi Communications Co. Ltd. The Journal's web site is located at http://www.sciencedirect.com/science/journal/2452199X | - |
dc.relation.ispartof | Bioactive Materials | - |
dc.rights | This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License. | - |
dc.subject | Cell | - |
dc.subject | Mechanotransduction | - |
dc.subject | Intracellular force | - |
dc.subject | Biomaterials | - |
dc.subject | Soft materials | - |
dc.title | Soft overcomes the hard: Flexible materials adapt to cell adhesion to promote cell mechanotransduction | - |
dc.type | Article | - |
dc.identifier.email | Chu, Z: zqchu@eee.hku.hk | - |
dc.identifier.authority | Chu, Z=rp02472 | - |
dc.description.nature | published_or_final_version | - |
dc.identifier.doi | 10.1016/j.bioactmat.2021.08.026 | - |
dc.identifier.pmid | 34901555 | - |
dc.identifier.pmcid | PMC8636665 | - |
dc.identifier.scopus | eid_2-s2.0-85119170938 | - |
dc.identifier.hkuros | 328157 | - |
dc.identifier.volume | 10 | - |
dc.identifier.spage | 397 | - |
dc.identifier.epage | 404 | - |
dc.identifier.isi | WOS:000743246500002 | - |
dc.publisher.place | China | - |