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Article: Effects of low-level light therapy on dentin hypersensitivity: a systematic review and meta-analysis
Title | Effects of low-level light therapy on dentin hypersensitivity: a systematic review and meta-analysis |
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Authors | |
Keywords | Low-level light therapy Dentin hypersensitivity Systematic review Meta-analysis |
Issue Date | 2021 |
Publisher | Springer for German Society of Oral and Maxillofacial Surgery. The Journal's web site is located at http://link.springer.de/link/service/journals/00784/index.htm |
Citation | Clinical Oral Investigations, 2021, v. 25 n. 12, p. 6571-6595 How to Cite? |
Abstract | Objective:
To investigate the treatment efficacy of low-level light therapy on dentin hypersensitivity.
Materials and methods:
Following the PRISMA guideline, six electronic databases supplemented with bibliographies were searched till December 2020. Two reviewers performed the screenings independently with a reliability assessment. Studies fulfilling the pre-registered eligibility criteria were included for risk-of-bias assessment and data synthesis.
Results:
Thirty-five articles ultimately informed this systematic review based on the eligibility criteria and underwent risk-of-bias assessment (ĸ = 0.86). Quantitative results were deduced by meta-analysis of 20 randomised controlled trials: LLLT showed favourable outcomes compared to placebos for immediate (SMD: 1.09, 95% CI: 0.47 to 1.70), interim (SMD: 1.32, 95% CI: 0.41 to 2.23), and persistent efficacies (SMD: 2.86, 95% CI: 1.98 to 3.74). However, substantial heterogeneity existed among included studies (I2: 64–95%). Regarding comparisons with other desensitising strategies, LLLT showed no significant benefits in DH alleviation over others except fluorides for interim efficacy (SMD: 0.31, 95% CI: 0.10 to 0.52) and persistent efficacy (SMD: 0.45, 95% CI: 0.03 to 0.86).
Conclusions:
This systematic review shows that LLLT has positive immediate, interim, and persistent DH-treatment efficacies compared with placebo. No superior treatment effects of LLLT were observed except fluoride agent use. Further studies are warranted—RCTs with low risk of bias, consistent technical settings, comprehensive assessments, and long follow-up periods.
Clinical relevance:
This systematic review bridges a critical research gap by analysing clinical evidence in the DH-alleviating efficacy of LLLT in comparison with placebo and other in-office desensitising strategies. |
Persistent Identifier | http://hdl.handle.net/10722/306478 |
ISSN | 2023 Impact Factor: 3.1 2023 SCImago Journal Rankings: 0.942 |
PubMed Central ID | |
ISI Accession Number ID |
DC Field | Value | Language |
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dc.contributor.author | Shan, Z | - |
dc.contributor.author | Ji, J | - |
dc.contributor.author | McGrath, C | - |
dc.contributor.author | Gu, M | - |
dc.contributor.author | Yang, Y | - |
dc.date.accessioned | 2021-10-22T07:35:11Z | - |
dc.date.available | 2021-10-22T07:35:11Z | - |
dc.date.issued | 2021 | - |
dc.identifier.citation | Clinical Oral Investigations, 2021, v. 25 n. 12, p. 6571-6595 | - |
dc.identifier.issn | 1432-6981 | - |
dc.identifier.uri | http://hdl.handle.net/10722/306478 | - |
dc.description.abstract | Objective: To investigate the treatment efficacy of low-level light therapy on dentin hypersensitivity. Materials and methods: Following the PRISMA guideline, six electronic databases supplemented with bibliographies were searched till December 2020. Two reviewers performed the screenings independently with a reliability assessment. Studies fulfilling the pre-registered eligibility criteria were included for risk-of-bias assessment and data synthesis. Results: Thirty-five articles ultimately informed this systematic review based on the eligibility criteria and underwent risk-of-bias assessment (ĸ = 0.86). Quantitative results were deduced by meta-analysis of 20 randomised controlled trials: LLLT showed favourable outcomes compared to placebos for immediate (SMD: 1.09, 95% CI: 0.47 to 1.70), interim (SMD: 1.32, 95% CI: 0.41 to 2.23), and persistent efficacies (SMD: 2.86, 95% CI: 1.98 to 3.74). However, substantial heterogeneity existed among included studies (I2: 64–95%). Regarding comparisons with other desensitising strategies, LLLT showed no significant benefits in DH alleviation over others except fluorides for interim efficacy (SMD: 0.31, 95% CI: 0.10 to 0.52) and persistent efficacy (SMD: 0.45, 95% CI: 0.03 to 0.86). Conclusions: This systematic review shows that LLLT has positive immediate, interim, and persistent DH-treatment efficacies compared with placebo. No superior treatment effects of LLLT were observed except fluoride agent use. Further studies are warranted—RCTs with low risk of bias, consistent technical settings, comprehensive assessments, and long follow-up periods. Clinical relevance: This systematic review bridges a critical research gap by analysing clinical evidence in the DH-alleviating efficacy of LLLT in comparison with placebo and other in-office desensitising strategies. | - |
dc.language | eng | - |
dc.publisher | Springer for German Society of Oral and Maxillofacial Surgery. The Journal's web site is located at http://link.springer.de/link/service/journals/00784/index.htm | - |
dc.relation.ispartof | Clinical Oral Investigations | - |
dc.rights | This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License. | - |
dc.subject | Low-level light therapy | - |
dc.subject | Dentin hypersensitivity | - |
dc.subject | Systematic review | - |
dc.subject | Meta-analysis | - |
dc.title | Effects of low-level light therapy on dentin hypersensitivity: a systematic review and meta-analysis | - |
dc.type | Article | - |
dc.identifier.email | McGrath, C: mcgrathc@hkucc.hku.hk | - |
dc.identifier.email | Gu, M: drgumin@hku.hk | - |
dc.identifier.email | Yang, Y: yangyanq@hku.hk | - |
dc.identifier.authority | McGrath, C=rp00037 | - |
dc.identifier.authority | Gu, M=rp01892 | - |
dc.identifier.authority | Yang, Y=rp00045 | - |
dc.description.nature | published_or_final_version | - |
dc.identifier.doi | 10.1007/s00784-021-04183-1 | - |
dc.identifier.pmid | 34642786 | - |
dc.identifier.pmcid | PMC8602177 | - |
dc.identifier.scopus | eid_2-s2.0-85117011840 | - |
dc.identifier.hkuros | 329066 | - |
dc.identifier.volume | 25 | - |
dc.identifier.issue | 12 | - |
dc.identifier.spage | 6571 | - |
dc.identifier.epage | 6595 | - |
dc.identifier.isi | WOS:000706570700001 | - |
dc.publisher.place | Germany | - |