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Article: Long-term persistence of SARS-CoV-2 neutralizing antibody responses after infection and estimates of the duration of protection
Title | Long-term persistence of SARS-CoV-2 neutralizing antibody responses after infection and estimates of the duration of protection |
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Authors | |
Keywords | COVID-19 SARS-CoV-2 Coronavirus Neutralizing antibody Kinetics Protection Immunity, duration |
Issue Date | 2021 |
Publisher | Elsevier: Creative Commons Licenses. The Journal's web site is located at https://www.journals.elsevier.com/eclinicalmedicine |
Citation | EClinicalMedicine, 2021, v. 41, article no. 101174 How to Cite? |
Abstract | Background:
The duration of immunity in SARS-CoV-2 infected people remains unclear. Neutralizing antibody responses are the best available correlate of protection against re-infection. Recent studies estimated that the correlate of 50% protection from re-infection was 20% of the mean convalescent neutralizing antibody titre.
Methods:
We collected sera from a cohort of 124 individuals with RT-PCR confirmed SARS-CoV-2 infections from Prince of Wales Hospital, Princess Margaret Hospital, Queen Elizabeth Hospital and Queen Mary Hospitals of the Hospital Authority of Hong Kong, for periods up to 386 days after symptom onset and tested these for antibody to SARS-CoV-2 using 50% virus plaque reduction neutralization tests (PRNT50), surrogate neutralization tests and spike receptor binding domain (RBD) binding antibody. Patients were recruited from 21 January 2020 to 16 February 2021 and follow-up samples were collected until 9th March 2021.
Findings:
Because the rate of antibody waning slows with time, we fitted lines of decay to 115 sera from 62 patients collected beyond 90 days after symptom onset and estimate that PRNT50 antibody will remain detectable for around 1,717 days after symptom onset and that levels conferring 50% protection will be maintained for around 990 days post-symptom onset, in symptomatic patients. This would potentially be affected by emerging virus variants. PRNT titres wane faster in children. There was a high level of correlation between PRNT50 antibody titers and the % of inhibition in surrogate virus neutralization tests.
Interpretation:
The data suggest that symptomatic COVID-19 disease is followed by relatively long-lived protection from re-infection by antigenically similar viruses.
Funding:
Health and Medical Research Fund, Commissioned research on Novel Coronavirus Disease (COVID-19) (Reference Nos. COVID190126 and COVID1903003) from the Food and Health Bureau and the Theme-based Research Scheme project no. T11–712/19-N, the University Grants Committee of the Hong Kong SAR Government. |
Persistent Identifier | http://hdl.handle.net/10722/308504 |
ISSN | 2023 Impact Factor: 9.6 2023 SCImago Journal Rankings: 3.522 |
PubMed Central ID | |
ISI Accession Number ID |
DC Field | Value | Language |
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dc.contributor.author | Lau, EHY | - |
dc.contributor.author | Hui, DSC | - |
dc.contributor.author | Tsang, OTY | - |
dc.contributor.author | Chan, WH | - |
dc.contributor.author | Kwan, MYW | - |
dc.contributor.author | Chiu, SS | - |
dc.contributor.author | Cheng, SMS | - |
dc.contributor.author | Ko, RLW | - |
dc.contributor.author | Li, JKC | - |
dc.contributor.author | Chaothai, S | - |
dc.contributor.author | Tsang, CH | - |
dc.contributor.author | Poon, LLM | - |
dc.contributor.author | Peiris, M | - |
dc.date.accessioned | 2021-12-01T07:54:13Z | - |
dc.date.available | 2021-12-01T07:54:13Z | - |
dc.date.issued | 2021 | - |
dc.identifier.citation | EClinicalMedicine, 2021, v. 41, article no. 101174 | - |
dc.identifier.issn | 2589-5370 | - |
dc.identifier.uri | http://hdl.handle.net/10722/308504 | - |
dc.description.abstract | Background: The duration of immunity in SARS-CoV-2 infected people remains unclear. Neutralizing antibody responses are the best available correlate of protection against re-infection. Recent studies estimated that the correlate of 50% protection from re-infection was 20% of the mean convalescent neutralizing antibody titre. Methods: We collected sera from a cohort of 124 individuals with RT-PCR confirmed SARS-CoV-2 infections from Prince of Wales Hospital, Princess Margaret Hospital, Queen Elizabeth Hospital and Queen Mary Hospitals of the Hospital Authority of Hong Kong, for periods up to 386 days after symptom onset and tested these for antibody to SARS-CoV-2 using 50% virus plaque reduction neutralization tests (PRNT50), surrogate neutralization tests and spike receptor binding domain (RBD) binding antibody. Patients were recruited from 21 January 2020 to 16 February 2021 and follow-up samples were collected until 9th March 2021. Findings: Because the rate of antibody waning slows with time, we fitted lines of decay to 115 sera from 62 patients collected beyond 90 days after symptom onset and estimate that PRNT50 antibody will remain detectable for around 1,717 days after symptom onset and that levels conferring 50% protection will be maintained for around 990 days post-symptom onset, in symptomatic patients. This would potentially be affected by emerging virus variants. PRNT titres wane faster in children. There was a high level of correlation between PRNT50 antibody titers and the % of inhibition in surrogate virus neutralization tests. Interpretation: The data suggest that symptomatic COVID-19 disease is followed by relatively long-lived protection from re-infection by antigenically similar viruses. Funding: Health and Medical Research Fund, Commissioned research on Novel Coronavirus Disease (COVID-19) (Reference Nos. COVID190126 and COVID1903003) from the Food and Health Bureau and the Theme-based Research Scheme project no. T11–712/19-N, the University Grants Committee of the Hong Kong SAR Government. | - |
dc.language | eng | - |
dc.publisher | Elsevier: Creative Commons Licenses. The Journal's web site is located at https://www.journals.elsevier.com/eclinicalmedicine | - |
dc.relation.ispartof | EClinicalMedicine | - |
dc.rights | This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License. | - |
dc.subject | COVID-19 | - |
dc.subject | SARS-CoV-2 | - |
dc.subject | Coronavirus | - |
dc.subject | Neutralizing antibody | - |
dc.subject | Kinetics | - |
dc.subject | Protection | - |
dc.subject | Immunity, duration | - |
dc.title | Long-term persistence of SARS-CoV-2 neutralizing antibody responses after infection and estimates of the duration of protection | - |
dc.type | Article | - |
dc.identifier.email | Lau, EHY: ehylau@hku.hk | - |
dc.identifier.email | Chiu, SS: ssschiu@hku.hk | - |
dc.identifier.email | Cheng, SMS: samuelms@hku.hk | - |
dc.identifier.email | Li, JKC: kc109698@hku.hk | - |
dc.identifier.email | Chaothai, S: bee1002@hku.hk | - |
dc.identifier.email | Tsang, CH: leohang@hku.hk | - |
dc.identifier.email | Poon, LLM: llmpoon@hkucc.hku.hk | - |
dc.identifier.email | Peiris, M: malik@hkucc.hku.hk | - |
dc.identifier.authority | Lau, EHY=rp01349 | - |
dc.identifier.authority | Chiu, SS=rp00421 | - |
dc.identifier.authority | Poon, LLM=rp00484 | - |
dc.identifier.authority | Peiris, M=rp00410 | - |
dc.description.nature | published_or_final_version | - |
dc.identifier.doi | 10.1016/j.eclinm.2021.101174 | - |
dc.identifier.pmid | 34746725 | - |
dc.identifier.pmcid | PMC8556690 | - |
dc.identifier.scopus | eid_2-s2.0-85122648134 | - |
dc.identifier.hkuros | 330687 | - |
dc.identifier.volume | 41 | - |
dc.identifier.spage | article no. 101174 | - |
dc.identifier.epage | article no. 101174 | - |
dc.identifier.isi | WOS:000723039100003 | - |
dc.publisher.place | United Kingdom | - |