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Article: HLA alleles associated with asparaginase hypersensitivity in Chinese children

TitleHLA alleles associated with asparaginase hypersensitivity in Chinese children
Authors
KeywordsHuman leukocyte antigens
Asparaginase
Hypersensitivity
Allergy
Chinese
Children
Issue Date2021
PublisherBioMed Central Ltd. The Journal's web site is located at http://www.jhoonline.org
Citation
Journal of Hematology & Oncology, 2021, v. 14, article no. 182 How to Cite?
AbstractAsparaginase is an important drug to treat childhood haematological malignancies. Data on the association between human leukocyte antigens (HLA) and asparaginase hypersensitivity among Chinese are lacking. We conducted a retrospective study to identify HLA alleles associated with asparaginase hypersensitivity among Chinese children with acute lymphoblastic leukaemia (ALL), mixed phenotype leukaemia and non-Hodgkin lymphoma (NHL), who received asparaginases with HLA typing performed between 2009 and 2019. 107 Chinese patients were analysed. 66.3% (71/107) developed hypersensitivity to at least one of the asparaginases. HLA-B*46:01 (OR 3.8, 95% CI 1.4–10.1, p < 0.01) and DRB1*09:01 (OR 4.3, 95% CI 1.6–11.4, p < 0.01) were significantly associated with L-asparaginase hypersensitivities, which remained significant after adjustment for age, gender and B cell ALL [HLA-B*46:01 (adjusted OR 3.5, 95% 1.3–10.5, p = 0.02) and DRB1*09:01 (OR 4.4, 95% CI 1.6–13.3, p < 0.01)].
Persistent Identifierhttp://hdl.handle.net/10722/309024
ISSN
2023 Impact Factor: 29.5
2023 SCImago Journal Rankings: 7.522
PubMed Central ID
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorChua, GT-
dc.contributor.authorRosa Duque, JS-
dc.contributor.authorCheuk, DKL-
dc.contributor.authorLeung, AWK-
dc.contributor.authorWong, WHS-
dc.contributor.authorLiu, APY-
dc.contributor.authorLee, PPW-
dc.contributor.authorHa, SY-
dc.contributor.authorChiang, AKS-
dc.contributor.authorHo, MHK-
dc.contributor.authorChu, WK-
dc.contributor.authorChan, YS-
dc.contributor.authorLuk, CW-
dc.contributor.authorLing, ASC-
dc.contributor.authorKwan, MYW-
dc.contributor.authorYiu, OKF-
dc.contributor.authorWong, ICK-
dc.contributor.authorLau, YL-
dc.contributor.authorLi, CK-
dc.contributor.authorLeung, WH-
dc.contributor.authorChan, GCF-
dc.contributor.authorIp, P-
dc.contributor.authorKwok, J-
dc.date.accessioned2021-12-14T01:39:34Z-
dc.date.available2021-12-14T01:39:34Z-
dc.date.issued2021-
dc.identifier.citationJournal of Hematology & Oncology, 2021, v. 14, article no. 182-
dc.identifier.issn1756-8722-
dc.identifier.urihttp://hdl.handle.net/10722/309024-
dc.description.abstractAsparaginase is an important drug to treat childhood haematological malignancies. Data on the association between human leukocyte antigens (HLA) and asparaginase hypersensitivity among Chinese are lacking. We conducted a retrospective study to identify HLA alleles associated with asparaginase hypersensitivity among Chinese children with acute lymphoblastic leukaemia (ALL), mixed phenotype leukaemia and non-Hodgkin lymphoma (NHL), who received asparaginases with HLA typing performed between 2009 and 2019. 107 Chinese patients were analysed. 66.3% (71/107) developed hypersensitivity to at least one of the asparaginases. HLA-B*46:01 (OR 3.8, 95% CI 1.4–10.1, p < 0.01) and DRB1*09:01 (OR 4.3, 95% CI 1.6–11.4, p < 0.01) were significantly associated with L-asparaginase hypersensitivities, which remained significant after adjustment for age, gender and B cell ALL [HLA-B*46:01 (adjusted OR 3.5, 95% 1.3–10.5, p = 0.02) and DRB1*09:01 (OR 4.4, 95% CI 1.6–13.3, p < 0.01)].-
dc.languageeng-
dc.publisherBioMed Central Ltd. The Journal's web site is located at http://www.jhoonline.org-
dc.relation.ispartofJournal of Hematology & Oncology-
dc.rightsThis work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.-
dc.subjectHuman leukocyte antigens-
dc.subjectAsparaginase-
dc.subjectHypersensitivity-
dc.subjectAllergy-
dc.subjectChinese-
dc.subjectChildren-
dc.titleHLA alleles associated with asparaginase hypersensitivity in Chinese children-
dc.typeArticle-
dc.identifier.emailChua, GT: cgt560@hku.hk-
dc.identifier.emailRosa Duque, JS: jsrduque@hku.hk-
dc.identifier.emailCheuk, DKL: klcheuk@hkucc.hku.hk-
dc.identifier.emailWong, WHS: whswong@hku.hk-
dc.identifier.emailLiu, APY: apyliu@hku.hk-
dc.identifier.emailLee, PPW: ppwlee@hku.hk-
dc.identifier.emailHa, SY: syha@hku.hk-
dc.identifier.emailChiang, AKS: chiangak@hku.hk-
dc.identifier.emailHo, MHK: marcoho@hku.hk-
dc.identifier.emailWong, ICK: wongick@hku.hk-
dc.identifier.emailLau, YL: lauylung@hku.hk-
dc.identifier.emailLeung, WH: leungwhf@hku.hk-
dc.identifier.emailChan, GCF: gcfchan@hku.hk-
dc.identifier.emailIp, P: patricip@hku.hk-
dc.identifier.emailKwok, J: kwoksy@hkucc.hku.hk-
dc.identifier.authorityChua, GT=rp02684-
dc.identifier.authorityRosa Duque, JS=rp02340-
dc.identifier.authorityLiu, APY=rp01357-
dc.identifier.authorityLee, PPW=rp00462-
dc.identifier.authorityChiang, AKS=rp00403-
dc.identifier.authorityWong, ICK=rp01480-
dc.identifier.authorityLau, YL=rp00361-
dc.identifier.authorityLeung, WH=rp02760-
dc.identifier.authorityChan, GCF=rp00431-
dc.identifier.authorityIp, P=rp01337-
dc.description.naturepublished_or_final_version-
dc.identifier.doi10.1186/s13045-021-01201-3-
dc.identifier.pmid34717720-
dc.identifier.pmcidPMC8557538-
dc.identifier.scopuseid_2-s2.0-85118257266-
dc.identifier.hkuros330815-
dc.identifier.volume14-
dc.identifier.spagearticle no. 182-
dc.identifier.epagearticle no. 182-
dc.identifier.isiWOS:000712969100004-
dc.publisher.placeUnited Kingdom-

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