Association between the pharmacological treatment of bipolar disorder and risk of traumatic injuries: a self-controlled case series study

Abstract

Background: Patients with bipolar disorder (BPD) are prone to engage in risk-taking behaviours and self-harm, contributing to higher risk of traumatic injuries requiring medical attention at the emergency room (ER).We hypothesize that pharmacological treatment of BPD could reduce the risk of traumatic injuries by alleviating symptoms but evidence remains unclear. This study aimed to examine the association between pharmacological treatment and the risk of ER admissions due to traumatic injuries. Methods: Individuals with BPD who received mood stabilizers and/or antipsychotics were identified using a population-based electronic healthcare records database in Hong Kong (2001-2019). A self-controlled case series design was applied to control for time-invariant confounders. Results: A total of 5040 out of 14021 adults with BPD who received pharmacological treatment and had incident ER admissions due to traumatic injuries from 2001-2019 were included. An increased risk of traumatic injuries was found 30 days before treatment (Incidence rate ratio (IRR) 4.44 (3.71-5.31), p<0.0001). After treatment initiation, the risk remained increased with a smaller magnitude, before returning to baseline (IRR 0.97 (0.88-1.06), p=0.50) during maintenance treatment. The direct comparison of the risk during treatment to that before and after treaetment showed a significant decrease. After treatment cessation, the risk was increased (IRR 1.34 (1.09-1.66), p=0.006). Conclusions: This study supports the hypothesis that pharmacological treatment of BPD was associated with a lower risk of ER admissions due to traumatic injuries but an increased risk after treatment cessation. Close monitoring of symptoms relapse is recommended to clinicians and patients if treatment cessation is warranted.