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Article: Whole-genome analysis of an extensive drug-resistant acinetobacter baumannii ST195 isolate from a recipient after DCD renal transplantation in China

TitleWhole-genome analysis of an extensive drug-resistant acinetobacter baumannii ST195 isolate from a recipient after DCD renal transplantation in China
Authors
KeywordsAcinetobacter baumannii
Dcd transplantation
Drug-resistant
Whole-Genome Analysis
Issue Date2017
Citation
Kidney and Blood Pressure Research, 2017, v. 42, n. 6, p. 1247-1257 How to Cite?
AbstractBackground/Aims: Infection with Acinetobacter baumannii was emerging as one of the leading causes of mortality after donation after cardiac death transpalantion. Methods: We reported a case of a recipient who underwent DCD renal transplantation and later got infected by A.baumannii. Etests were done to verify the susceptibility test results in clinic. Whole-genome analysis was applied to investigate the resistant mechanism at gene level. Results: The pathogen was isolated from his draining liquid the day after the surgery, and susceptibility test reavealed that it was sensitive to tigecycline. However, the isolate obtained from the draining liquid became tigecycline-resistant after fifteen-day administration of tigecycline. The Susceptibility tests showed that the pathogen recovered from tigecycline resistance and became intermediated to tigecycline. Whole-Genome analysis revealed the genetic level change leading to tigecycline resistance and we identified the location of mutation by comparing the whole genome sequence of the isolates. Three loci were figured out which may contribute to drug resistance, including genes encoding HTH domain protein, MFS transporter and AdeS. Conclusion: Understanding the genetic characteristics associated with drug resistance mechanism and antimicrobial profiles of pathogen is important in controlling infection outbreak and preventing serious complications and gives a new insight into the development of antimicrobial agents.
Persistent Identifierhttp://hdl.handle.net/10722/324522
ISSN
2023 Impact Factor: 2.3
2023 SCImago Journal Rankings: 0.674
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorJiang, Hong-
dc.contributor.authorCao, Luxi-
dc.contributor.authorShen, Qixia-
dc.contributor.authorQu, Lihui-
dc.contributor.authorJiang, Yan-
dc.contributor.authorQu, Tingting-
dc.contributor.authorZhang, Jian-
dc.contributor.authorLu, Yingying-
dc.contributor.authorLi, Bingjue-
dc.contributor.authorZhu, Chaohong-
dc.contributor.authorLiu, Guangjun-
dc.contributor.authorWang, Rending-
dc.contributor.authorChen, Miao-
dc.contributor.authorWang, Yucheng-
dc.contributor.authorWang, Yanfei-
dc.contributor.authorFeng, Shi-
dc.contributor.authorWang, Junwen-
dc.contributor.authorYu, Yunsong-
dc.contributor.authorWu, Jianyong-
dc.contributor.authorChen, Jianghua-
dc.date.accessioned2023-02-03T07:03:46Z-
dc.date.available2023-02-03T07:03:46Z-
dc.date.issued2017-
dc.identifier.citationKidney and Blood Pressure Research, 2017, v. 42, n. 6, p. 1247-1257-
dc.identifier.issn1420-4096-
dc.identifier.urihttp://hdl.handle.net/10722/324522-
dc.description.abstractBackground/Aims: Infection with Acinetobacter baumannii was emerging as one of the leading causes of mortality after donation after cardiac death transpalantion. Methods: We reported a case of a recipient who underwent DCD renal transplantation and later got infected by A.baumannii. Etests were done to verify the susceptibility test results in clinic. Whole-genome analysis was applied to investigate the resistant mechanism at gene level. Results: The pathogen was isolated from his draining liquid the day after the surgery, and susceptibility test reavealed that it was sensitive to tigecycline. However, the isolate obtained from the draining liquid became tigecycline-resistant after fifteen-day administration of tigecycline. The Susceptibility tests showed that the pathogen recovered from tigecycline resistance and became intermediated to tigecycline. Whole-Genome analysis revealed the genetic level change leading to tigecycline resistance and we identified the location of mutation by comparing the whole genome sequence of the isolates. Three loci were figured out which may contribute to drug resistance, including genes encoding HTH domain protein, MFS transporter and AdeS. Conclusion: Understanding the genetic characteristics associated with drug resistance mechanism and antimicrobial profiles of pathogen is important in controlling infection outbreak and preventing serious complications and gives a new insight into the development of antimicrobial agents.-
dc.languageeng-
dc.relation.ispartofKidney and Blood Pressure Research-
dc.rightsThis work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.-
dc.subjectAcinetobacter baumannii-
dc.subjectDcd transplantation-
dc.subjectDrug-resistant-
dc.subjectWhole-Genome Analysis-
dc.titleWhole-genome analysis of an extensive drug-resistant acinetobacter baumannii ST195 isolate from a recipient after DCD renal transplantation in China-
dc.typeArticle-
dc.description.naturepublished_or_final_version-
dc.identifier.doi10.1159/000485928-
dc.identifier.pmid29248914-
dc.identifier.scopuseid_2-s2.0-85048367780-
dc.identifier.volume42-
dc.identifier.issue6-
dc.identifier.spage1247-
dc.identifier.epage1257-
dc.identifier.eissn1423-0143-
dc.identifier.isiWOS:000423291800027-

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