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Article: Fabrication of flexible microlens arrays for parallel super-resolution imaging

TitleFabrication of flexible microlens arrays for parallel super-resolution imaging
Authors
KeywordsMicrolens array
Microsphere
Optical microscopy
PDMS
Super-resolution imaging
Issue Date2020
Citation
Applied Surface Science, 2020, v. 504, article no. 144375 How to Cite?
AbstractThe development of optical microscopy has greatly promoted the progress of biological fields, providing outstanding observation tools for genetics, molecular biology, and bioengineering technology, from the macro- to the micro-scale. Owing to the optical diffraction limit, the imaging resolution of traditional optical microscopy is limited. Recently, the use of microspheres has been demonstrated to aid the capability to realize super-resolution imaging under white light illumination; however, using this approach, the imaging field of view is only a few microns, due to the size of the microspheres. In this paper, we fabricated microlens arrays by embedding microspheres into polydimethylsiloxane (PDMS) films. Using this method, we have successfully achieved parallel imaging under the sub-diffraction-limited resolution using multiple microspheres with a magnification up to ×2.59–×2.99, and the observed results are consistent with finite-difference time-domain (FDTD) simulation results. Furthermore, two imaging modes were developed: the microlens array-based dynamic scanning imaging mode and the stochastic microlens array region imaging overlay reconstruction mode, a surface image of 900 μm2 was presented stitched with 210 images. This study combines the advantages of parallel imaging and dynamic imaging to increase efficiency and observation range.
Persistent Identifierhttp://hdl.handle.net/10722/325457
ISSN
2023 Impact Factor: 6.3
2023 SCImago Journal Rankings: 1.210
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorZhang, Tianyao-
dc.contributor.authorLi, Pan-
dc.contributor.authorYu, Haibo-
dc.contributor.authorWang, Feifei-
dc.contributor.authorWang, Xiaoduo-
dc.contributor.authorYang, Tie-
dc.contributor.authorYang, Wenguang-
dc.contributor.authorLi, Wen J.-
dc.contributor.authorWang, Yuechao-
dc.contributor.authorLiu, Lianqing-
dc.date.accessioned2023-02-27T07:33:28Z-
dc.date.available2023-02-27T07:33:28Z-
dc.date.issued2020-
dc.identifier.citationApplied Surface Science, 2020, v. 504, article no. 144375-
dc.identifier.issn0169-4332-
dc.identifier.urihttp://hdl.handle.net/10722/325457-
dc.description.abstractThe development of optical microscopy has greatly promoted the progress of biological fields, providing outstanding observation tools for genetics, molecular biology, and bioengineering technology, from the macro- to the micro-scale. Owing to the optical diffraction limit, the imaging resolution of traditional optical microscopy is limited. Recently, the use of microspheres has been demonstrated to aid the capability to realize super-resolution imaging under white light illumination; however, using this approach, the imaging field of view is only a few microns, due to the size of the microspheres. In this paper, we fabricated microlens arrays by embedding microspheres into polydimethylsiloxane (PDMS) films. Using this method, we have successfully achieved parallel imaging under the sub-diffraction-limited resolution using multiple microspheres with a magnification up to ×2.59–×2.99, and the observed results are consistent with finite-difference time-domain (FDTD) simulation results. Furthermore, two imaging modes were developed: the microlens array-based dynamic scanning imaging mode and the stochastic microlens array region imaging overlay reconstruction mode, a surface image of 900 μm2 was presented stitched with 210 images. This study combines the advantages of parallel imaging and dynamic imaging to increase efficiency and observation range.-
dc.languageeng-
dc.relation.ispartofApplied Surface Science-
dc.subjectMicrolens array-
dc.subjectMicrosphere-
dc.subjectOptical microscopy-
dc.subjectPDMS-
dc.subjectSuper-resolution imaging-
dc.titleFabrication of flexible microlens arrays for parallel super-resolution imaging-
dc.typeArticle-
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1016/j.apsusc.2019.144375-
dc.identifier.scopuseid_2-s2.0-85075345106-
dc.identifier.volume504-
dc.identifier.spagearticle no. 144375-
dc.identifier.epagearticle no. 144375-
dc.identifier.isiWOS:000502040600137-

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