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Article: Thiophene donor for NIR-II fluorescence imaging-guided photothermal/photodynamic/chemo combination therapy

TitleThiophene donor for NIR-II fluorescence imaging-guided photothermal/photodynamic/chemo combination therapy
Authors
KeywordsMolecular imaging
NIR-II fluorophore probe
Photothermal/photodynamic/chemo combination therapy
Single laser triggering
Thiophene donor
Issue Date2021
Citation
Acta Biomaterialia, 2021, v. 127, p. 287-297 How to Cite?
AbstractOrganic fluorophores/photosensitizers have been widely used in biological imaging and photodynamic and photothermal combination therapy in the first near-infrared (NIR-I) window. However, their applications in the second near-infrared (NIR-II) window are still limited primarily due to low fluorescence quantum yields (QYs). Here, a boron dipyrromethene (BDP) is created as a molecularly engineered thiophene donor unit with high QYs to the redshift. Thiophene insertion initiates substantial redshifts of the absorbance as compared to its counterparts in which iodine is introduced. The fluorescent molecule can be triggered by an NIR laser with a single wavelength, thereby producing emission in the NIR-II windows. Single NIR laser-triggered phototherapeutic nanoparticles (NPs) are developed by encapsulating the BDP and the chemotherapeutic drug docetaxel (DTX) by using a synthetic amphiphilic poly(styrene-co-chloromethyl styrene)-graft-poly(ethylene glycol) functionalized with folic acid (FA). These BDP-T-N-DTX-FA NPs not only show superior solubility and high singlet oxygen QY (ΦΔ=62%) but also demonstrate single NIR laser-triggered multifunctional characteristics. After intravenous administration of the NPs into 4T1 tumor-bearing mice, the accumulation of the NPs in the tumor showed a high signal-to-background ratio (11.8). Furthermore, 4T1 tumors in mice were almost eradicated by DTX released from the BDP-T-N-DTX-FA NPs under single NIR laser excitation and the combination of photodynamic therapy (PDT) and photothermic therapy (PTT). Statement of significance: The application of organic photosensitizers is still limited primarily due to low fluorescence quantum yields (QYs) in the second near-infrared (NIR-II) window. Here, a boron dipyrromethene (BDP) as a molecularly engineered thiophene donor unit with high QYs to the redshift is created. Phototherapeutic nanoparticles (NPs) are developed by encapsulating the BDP and docetaxel (DTX) using a synthetic amphiphilic poly(styrene-co-chloromethyl styrene)-graft-poly(ethylene glycol) functionalized with folic acid (FA). These BDP-T-N-DTX-FA NPs not only show high singlet oxygen QY (ΦΔ=62%) but also demonstrate single NIR laser-triggered multifunctional characteristics and a high signal-to-background ratio (11.8). Furthermore, 4T1 tumors in mice were almost eradicated by DTX released from the BDP-T-N-DTX-FA NPs under single NIR laser excitation and the PDT/PTT combination therapy.
Persistent Identifierhttp://hdl.handle.net/10722/325528
ISSN
2023 Impact Factor: 9.4
2023 SCImago Journal Rankings: 1.925
ISI Accession Number ID
Errata

 

DC FieldValueLanguage
dc.contributor.authorLiu, Qiang-
dc.contributor.authorTian, Jiangwei-
dc.contributor.authorTian, Ye-
dc.contributor.authorSun, Qinchao-
dc.contributor.authorSun, Dan-
dc.contributor.authorLiu, Dewen-
dc.contributor.authorWang, Feifei-
dc.contributor.authorXu, Haijun-
dc.contributor.authorYing, Guoliang-
dc.contributor.authorWang, Jigang-
dc.contributor.authorYetisen, Ali K.-
dc.contributor.authorJiang, Nan-
dc.date.accessioned2023-02-27T07:34:01Z-
dc.date.available2023-02-27T07:34:01Z-
dc.date.issued2021-
dc.identifier.citationActa Biomaterialia, 2021, v. 127, p. 287-297-
dc.identifier.issn1742-7061-
dc.identifier.urihttp://hdl.handle.net/10722/325528-
dc.description.abstractOrganic fluorophores/photosensitizers have been widely used in biological imaging and photodynamic and photothermal combination therapy in the first near-infrared (NIR-I) window. However, their applications in the second near-infrared (NIR-II) window are still limited primarily due to low fluorescence quantum yields (QYs). Here, a boron dipyrromethene (BDP) is created as a molecularly engineered thiophene donor unit with high QYs to the redshift. Thiophene insertion initiates substantial redshifts of the absorbance as compared to its counterparts in which iodine is introduced. The fluorescent molecule can be triggered by an NIR laser with a single wavelength, thereby producing emission in the NIR-II windows. Single NIR laser-triggered phototherapeutic nanoparticles (NPs) are developed by encapsulating the BDP and the chemotherapeutic drug docetaxel (DTX) by using a synthetic amphiphilic poly(styrene-co-chloromethyl styrene)-graft-poly(ethylene glycol) functionalized with folic acid (FA). These BDP-T-N-DTX-FA NPs not only show superior solubility and high singlet oxygen QY (ΦΔ=62%) but also demonstrate single NIR laser-triggered multifunctional characteristics. After intravenous administration of the NPs into 4T1 tumor-bearing mice, the accumulation of the NPs in the tumor showed a high signal-to-background ratio (11.8). Furthermore, 4T1 tumors in mice were almost eradicated by DTX released from the BDP-T-N-DTX-FA NPs under single NIR laser excitation and the combination of photodynamic therapy (PDT) and photothermic therapy (PTT). Statement of significance: The application of organic photosensitizers is still limited primarily due to low fluorescence quantum yields (QYs) in the second near-infrared (NIR-II) window. Here, a boron dipyrromethene (BDP) as a molecularly engineered thiophene donor unit with high QYs to the redshift is created. Phototherapeutic nanoparticles (NPs) are developed by encapsulating the BDP and docetaxel (DTX) using a synthetic amphiphilic poly(styrene-co-chloromethyl styrene)-graft-poly(ethylene glycol) functionalized with folic acid (FA). These BDP-T-N-DTX-FA NPs not only show high singlet oxygen QY (ΦΔ=62%) but also demonstrate single NIR laser-triggered multifunctional characteristics and a high signal-to-background ratio (11.8). Furthermore, 4T1 tumors in mice were almost eradicated by DTX released from the BDP-T-N-DTX-FA NPs under single NIR laser excitation and the PDT/PTT combination therapy.-
dc.languageeng-
dc.relation.ispartofActa Biomaterialia-
dc.subjectMolecular imaging-
dc.subjectNIR-II fluorophore probe-
dc.subjectPhotothermal/photodynamic/chemo combination therapy-
dc.subjectSingle laser triggering-
dc.subjectThiophene donor-
dc.titleThiophene donor for NIR-II fluorescence imaging-guided photothermal/photodynamic/chemo combination therapy-
dc.typeArticle-
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1016/j.actbio.2021.03.064-
dc.identifier.pmid33831570-
dc.identifier.scopuseid_2-s2.0-85106278940-
dc.identifier.volume127-
dc.identifier.spage287-
dc.identifier.epage297-
dc.identifier.eissn1878-7568-
dc.identifier.isiWOS:000653434900009-
dc.relation.erratumdoi:10.1016/j.actbio.2022.01.026-
dc.relation.erratumeid:eid_2-s2.0-85123107182-

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