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Article: Diabetes with poor-control HbA1c is cardiovascular disease ‘risk equivalent’ for mortality: UK Biobank and Hong Kong population-based cohort study
Title | Diabetes with poor-control HbA1c is cardiovascular disease ‘risk equivalent’ for mortality: UK Biobank and Hong Kong population-based cohort study |
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Authors | |
Issue Date | 1-Jan-2023 |
Publisher | BMJ Publishing Group |
Citation | BMJ Open Diabetes Research and Care, 2023, v. 11, n. 1, p. e003075 How to Cite? |
Abstract | INTRODUCTION: Type 2 diabetes mellitus (T2DM) has traditionally been considered a coronary heart disease 'risk equivalent' for future mortality, but significant heterogeneity exists across people with T2DM. This study aims to determine the risk of all-cause mortality of patients with cardiovascular disease (CVD) and T2DM in UK and Hong Kong, with stratifications for hemoglobin A1 (HbA1c) concentrations, compared with those without CVD and diabetes mellitus. RESEARCH DESIGN AND METHODS: This is a retrospective cohort study of 3 839 391 adults from Hong Kong and a prospective cohort study of 497 779 adults from the UK Biobank. Individuals were divided into seven disease groups: (1) no T2DM and CVD, (2) T2DM only with HbA1c <7%, (3) T2DM only with HbA1c 7%-7.9%, (4) T2DM only with HbA1c 8%-8.9%, (5) T2DM only with HbA1c ≥9%, (6) CVD only, and (7) T2DM and CVD. Differences in all-cause mortality between groups were examined using Cox regression. RESULTS: After around 10 years of median follow-up, 423 818 and 19 844 deaths were identified in the Hong Kong cohort and UK Biobank, respectively. Compared with individuals without T2DM and CVD, the adjusted HR for all-cause mortality in the other six disease groups for the Hong Kong cohort was 1.25 (95% CI 1.23 to 1.27) for T2DM only with HbA1c [removed] |
Persistent Identifier | http://hdl.handle.net/10722/328409 |
ISSN | 2023 Impact Factor: 3.7 2023 SCImago Journal Rankings: 1.479 |
ISI Accession Number ID |
DC Field | Value | Language |
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dc.contributor.author | Wan, EYF | - |
dc.contributor.author | Yu, EYT | - |
dc.contributor.author | Mak, IL | - |
dc.contributor.author | Youn, HM | - |
dc.contributor.author | Chan, KS | - |
dc.contributor.author | Chan, EWY | - |
dc.contributor.author | Wong, ICK | - |
dc.contributor.author | Lam, CLK | - |
dc.date.accessioned | 2023-06-28T04:44:33Z | - |
dc.date.available | 2023-06-28T04:44:33Z | - |
dc.date.issued | 2023-01-01 | - |
dc.identifier.citation | BMJ Open Diabetes Research and Care, 2023, v. 11, n. 1, p. e003075 | - |
dc.identifier.issn | 2052-4897 | - |
dc.identifier.uri | http://hdl.handle.net/10722/328409 | - |
dc.description.abstract | <p> INTRODUCTION: Type 2 diabetes mellitus (T2DM) has traditionally been considered a coronary heart disease 'risk equivalent' for future mortality, but significant heterogeneity exists across people with T2DM. This study aims to determine the risk of all-cause mortality of patients with cardiovascular disease (CVD) and T2DM in UK and Hong Kong, with stratifications for hemoglobin A1 (HbA1c) concentrations, compared with those without CVD and diabetes mellitus. RESEARCH DESIGN AND METHODS: This is a retrospective cohort study of 3 839 391 adults from Hong Kong and a prospective cohort study of 497 779 adults from the UK Biobank. Individuals were divided into seven disease groups: (1) no T2DM and CVD, (2) T2DM only with HbA1c <7%, (3) T2DM only with HbA1c 7%-7.9%, (4) T2DM only with HbA1c 8%-8.9%, (5) T2DM only with HbA1c ≥9%, (6) CVD only, and (7) T2DM and CVD. Differences in all-cause mortality between groups were examined using Cox regression. RESULTS: After around 10 years of median follow-up, 423 818 and 19 844 deaths were identified in the Hong Kong cohort and UK Biobank, respectively. Compared with individuals without T2DM and CVD, the adjusted HR for all-cause mortality in the other six disease groups for the Hong Kong cohort was 1.25 (95% CI 1.23 to 1.27) for T2DM only with HbA1c [removed] <br></p> | - |
dc.language | eng | - |
dc.publisher | BMJ Publishing Group | - |
dc.relation.ispartof | BMJ Open Diabetes Research and Care | - |
dc.title | Diabetes with poor-control HbA1c is cardiovascular disease ‘risk equivalent’ for mortality: UK Biobank and Hong Kong population-based cohort study | - |
dc.type | Article | - |
dc.identifier.doi | 10.1136/bmjdrc-2022-003075 | - |
dc.identifier.hkuros | 344607 | - |
dc.identifier.volume | 11 | - |
dc.identifier.issue | 1 | - |
dc.identifier.spage | e003075 | - |
dc.identifier.eissn | 2052-4897 | - |
dc.identifier.isi | WOS:000914857300001 | - |
dc.identifier.issnl | 2052-4897 | - |