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Article: Preparation of Dye Molecule-Intercalated MoO3 Organic/Inorganic Superlattice Nanoparticles for Fluorescence Imaging-Guided Catalytic Therapy

TitlePreparation of Dye Molecule-Intercalated MoO<inf>3</inf> Organic/Inorganic Superlattice Nanoparticles for Fluorescence Imaging-Guided Catalytic Therapy
Authors
Keywordscatalytic therapy
fluorescence imaging
layered MoO 3
organic intercalation
organic/inorganic superlattices
Issue Date2022
Citation
Small, 2022, v. 18, n. 25, article no. 2200595 How to Cite?
AbstractIntercalation of organic molecules into the van der Waals gaps of layered materials allows for the preparation of organic/inorganic superlattices for varying promising applications. Herein, the preparation of a series of dye molecule/MoO3 organic/inorganic superlattice nanoparticles by aqueous intercalation of several dye molecules into layered MoO3 for fluorescence imaging-guided catalytic therapy is reported. The long MoO3 nanobelts are treated by ball milling and subsequent aqueous intercalation followed by a cation ion exchange to obtain the dye molecule-intercalated MoO3 organic/inorganic superlattices. Importantly, because of the activation induced by organic intercalation, the Nile blue (NB)-intercalated MoO3-x (NB-MoO3-x) nanoparticles show excellent catalytic activity for the generation of reactive oxygen species, that is, hydroxyl radical (·OH) and superoxide anion (·O2−), through catalyzing H2O2 and O2, respectively. Moreover, the intense fluorescence of the intercalated NB molecules endows NB-MoO3-x with the in vivo fluorescence imaging capability. Thus, the polyvinylpyrrolidone-modified NB-MoO3-x nanoparticles can be used for tumor-specific catalytic therapy to realize efficient cancer cell elimination in vitro and fluorescence imaging-guided tumor ablation in vivo.
Persistent Identifierhttp://hdl.handle.net/10722/329852
ISSN
2023 Impact Factor: 13.0
2023 SCImago Journal Rankings: 3.348
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorHu, Tingting-
dc.contributor.authorLiu, Qian-
dc.contributor.authorZhou, Zhan-
dc.contributor.authorZhao, Wei-
dc.contributor.authorHuang, Haoxin-
dc.contributor.authorMeng, Fanqi-
dc.contributor.authorLiu, Wanqiang-
dc.contributor.authorZhang, Qinghua-
dc.contributor.authorGu, Lin-
dc.contributor.authorLiang, Ruizheng-
dc.contributor.authorTan, Chaoliang-
dc.date.accessioned2023-08-09T03:35:48Z-
dc.date.available2023-08-09T03:35:48Z-
dc.date.issued2022-
dc.identifier.citationSmall, 2022, v. 18, n. 25, article no. 2200595-
dc.identifier.issn1613-6810-
dc.identifier.urihttp://hdl.handle.net/10722/329852-
dc.description.abstractIntercalation of organic molecules into the van der Waals gaps of layered materials allows for the preparation of organic/inorganic superlattices for varying promising applications. Herein, the preparation of a series of dye molecule/MoO3 organic/inorganic superlattice nanoparticles by aqueous intercalation of several dye molecules into layered MoO3 for fluorescence imaging-guided catalytic therapy is reported. The long MoO3 nanobelts are treated by ball milling and subsequent aqueous intercalation followed by a cation ion exchange to obtain the dye molecule-intercalated MoO3 organic/inorganic superlattices. Importantly, because of the activation induced by organic intercalation, the Nile blue (NB)-intercalated MoO3-x (NB-MoO3-x) nanoparticles show excellent catalytic activity for the generation of reactive oxygen species, that is, hydroxyl radical (·OH) and superoxide anion (·O2−), through catalyzing H2O2 and O2, respectively. Moreover, the intense fluorescence of the intercalated NB molecules endows NB-MoO3-x with the in vivo fluorescence imaging capability. Thus, the polyvinylpyrrolidone-modified NB-MoO3-x nanoparticles can be used for tumor-specific catalytic therapy to realize efficient cancer cell elimination in vitro and fluorescence imaging-guided tumor ablation in vivo.-
dc.languageeng-
dc.relation.ispartofSmall-
dc.subjectcatalytic therapy-
dc.subjectfluorescence imaging-
dc.subjectlayered MoO 3-
dc.subjectorganic intercalation-
dc.subjectorganic/inorganic superlattices-
dc.titlePreparation of Dye Molecule-Intercalated MoO<inf>3</inf> Organic/Inorganic Superlattice Nanoparticles for Fluorescence Imaging-Guided Catalytic Therapy-
dc.typeArticle-
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1002/smll.202200595-
dc.identifier.scopuseid_2-s2.0-85130292819-
dc.identifier.volume18-
dc.identifier.issue25-
dc.identifier.spagearticle no. 2200595-
dc.identifier.epagearticle no. 2200595-
dc.identifier.eissn1613-6829-
dc.identifier.isiWOS:000798574300001-

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