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Article: In vivo neuronal and astrocytic activation in somatosensory cortex by acupuncture stimuli
Title | In vivo neuronal and astrocytic activation in somatosensory cortex by acupuncture stimuli |
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Authors | |
Keywords | acupuncture astrocyte chemogenetic N-methyl-D-Aspartate receptor neuron somatosensory cortex transient receptor potential A1 two-photon in vivo imaging |
Issue Date | 1-Nov-2022 |
Publisher | Medknow Publications |
Citation | Neural Regeneration Research, 2022, v. 17, n. 11, p. 2526-2529 How to Cite? |
Abstract | Acupuncture is a medical treatment that has been widely practiced in China for over 3000 years, yet the neural mechanisms of acupuncture are not fully understood. We hypothesized that neurons and astrocytes act independently and synergistically under acupuncture stimulation. To investigate this, we used two-photon in vivo calcium recording to observe the effects of acupuncture stimulation at ST36 (Zusanli) in mice. Acupuncture stimulation in peripheral acupoints potentiated calcium signals of pyramidal neurons and astrocytes in the somatosensory cortex and resulted in late-onset calcium transients in astrocytes. Chemogenetic inhibition of neurons augmented the astrocytic activity. These findings suggest that acupuncture activates neuronal and astrocytic activity in the somatosensory cortex and provide evidence for the involvement of both neurons and astrocytes in acupuncture treatment. |
Persistent Identifier | http://hdl.handle.net/10722/330943 |
ISSN | 2023 Impact Factor: 5.9 2023 SCImago Journal Rankings: 0.967 |
ISI Accession Number ID |
DC Field | Value | Language |
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dc.contributor.author | Chang, Xiao Yue | - |
dc.contributor.author | Chen, Kai | - |
dc.contributor.author | Cheng, Tong | - |
dc.contributor.author | Lai, Pui To | - |
dc.contributor.author | Zhang, Li | - |
dc.contributor.author | So, Kwok Fai | - |
dc.contributor.author | Yang, Edward | - |
dc.date.accessioned | 2023-09-21T06:51:21Z | - |
dc.date.available | 2023-09-21T06:51:21Z | - |
dc.date.issued | 2022-11-01 | - |
dc.identifier.citation | Neural Regeneration Research, 2022, v. 17, n. 11, p. 2526-2529 | - |
dc.identifier.issn | 1673-5374 | - |
dc.identifier.uri | http://hdl.handle.net/10722/330943 | - |
dc.description.abstract | <p>Acupuncture is a medical treatment that has been widely practiced in China for over 3000 years, yet the neural mechanisms of acupuncture are not fully understood. We hypothesized that neurons and astrocytes act independently and synergistically under acupuncture stimulation. To investigate this, we used two-photon <em>in vivo</em> calcium recording to observe the effects of acupuncture stimulation at ST36 (<em>Zusanli</em>) in mice. Acupuncture stimulation in peripheral acupoints potentiated calcium signals of pyramidal neurons and astrocytes in the somatosensory cortex and resulted in late-onset calcium transients in astrocytes. Chemogenetic inhibition of neurons augmented the astrocytic activity. These findings suggest that acupuncture activates neuronal and astrocytic activity in the somatosensory cortex and provide evidence for the involvement of both neurons and astrocytes in acupuncture treatment.</p> | - |
dc.language | eng | - |
dc.publisher | Medknow Publications | - |
dc.relation.ispartof | Neural Regeneration Research | - |
dc.rights | This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License. | - |
dc.subject | acupuncture | - |
dc.subject | astrocyte | - |
dc.subject | chemogenetic | - |
dc.subject | N-methyl-D-Aspartate receptor | - |
dc.subject | neuron | - |
dc.subject | somatosensory cortex | - |
dc.subject | transient receptor potential A1 | - |
dc.subject | two-photon in vivo imaging | - |
dc.title | In vivo neuronal and astrocytic activation in somatosensory cortex by acupuncture stimuli | - |
dc.type | Article | - |
dc.identifier.doi | 10.4103/1673-5374.339003 | - |
dc.identifier.scopus | eid_2-s2.0-85129821559 | - |
dc.identifier.volume | 17 | - |
dc.identifier.issue | 11 | - |
dc.identifier.spage | 2526 | - |
dc.identifier.epage | 2529 | - |
dc.identifier.eissn | 1876-7958 | - |
dc.identifier.isi | WOS:000866351500059 | - |
dc.identifier.issnl | 1673-5374 | - |