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Article: Genome-wide association study of lung adenocarcinoma in East Asia and comparison with a European population

TitleGenome-wide association study of lung adenocarcinoma in East Asia and comparison with a European population
Authors
Issue Date26-May-2023
PublisherNature Research
Citation
Nature Communications, 2023, v. 14, n. 1 How to Cite?
Abstract

Lung adenocarcinoma is the most common type of lung cancer. Known risk variants explain only a small fraction of lung adenocarcinoma heritability. Here, we conducted a two-stage genome-wide association study of lung adenocarcinoma of East Asian ancestry (21,658 cases and 150,676 controls; 54.5% never-smokers) and identified 12 novel susceptibility variants, bringing the total number to 28 at 25 independent loci. Transcriptome-wide association analyses together with colocalization studies using a Taiwanese lung expression quantitative trait loci dataset (n=115) identified novel candidate genes, including FADS1 at 11q12 and ELF5 at 11p13. In a multi-ancestry meta-analysis of East Asian and European studies, four loci were identified at 2p11, 4q32, 16q23, and 18q12. At the same time, most of our findings in East Asian populations showed no evidence of association in European populations. In our studies drawn from East Asian populations, a polygenic risk score based on the 25 loci had a stronger association in never-smokers vs. individuals with a history of smoking (P-interaction=0.0058). These findings provide new insights into the etiology of lung adenocarcinoma in individuals from East Asian populations, which could be important in developing translational applications.


Persistent Identifierhttp://hdl.handle.net/10722/331528
ISSN
2023 Impact Factor: 14.7
2023 SCImago Journal Rankings: 4.887
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorShi, JX-
dc.contributor.authorShiraishi, K-
dc.contributor.authorChoi, JY-
dc.contributor.authorMatsuo, K-
dc.contributor.authorChen, TY-
dc.contributor.authorDai, JC-
dc.contributor.authorHung, RJ-
dc.contributor.authorChen, KX-
dc.contributor.authorShu, XO-
dc.contributor.authorKim, YT-
dc.contributor.authorLandi, MT-
dc.contributor.authorLin, DX-
dc.contributor.authorZheng, W-
dc.contributor.authorYin, ZH-
dc.contributor.authorZhou, BS-
dc.contributor.authorSong, B-
dc.contributor.authorWang, JC-
dc.contributor.authorSeow, WJ-
dc.contributor.authorSong, L-
dc.contributor.authorChang, IS-
dc.contributor.authorHu, W-
dc.contributor.authorChien, LH-
dc.contributor.authorCai, QY-
dc.contributor.authorHong, YC-
dc.contributor.authorKim, HN-
dc.contributor.authorWu, YL-
dc.contributor.authorWong, MP-
dc.contributor.authorRichardson, BD-
dc.contributor.authorFunderburk, KM-
dc.contributor.authorLi, SL-
dc.contributor.authorZhang, TW-
dc.contributor.authorBreeze, C-
dc.contributor.authorWang, ZM-
dc.contributor.authorBlechter, B-
dc.contributor.authorBassig, BA-
dc.contributor.authorKim, JH-
dc.contributor.authorAlbanes, D-
dc.contributor.authorWong, JYY-
dc.contributor.authorShin, MH-
dc.contributor.authorChung, LP-
dc.contributor.authorYang, Y-
dc.contributor.authorAn, SJ-
dc.contributor.authorZheng, H-
dc.contributor.authorYatabe, Y-
dc.contributor.authorZhang, XC-
dc.contributor.authorKim, YC-
dc.contributor.authorCaporaso, NE-
dc.contributor.authorChang, J-
dc.contributor.authorHo, JCM-
dc.contributor.authorKubo, M-
dc.contributor.authorDaigo, Y-
dc.contributor.authorSong, M-
dc.contributor.authorMomozawa, Y-
dc.contributor.authorKamatani, Y-
dc.contributor.authorKobayashi, M-
dc.contributor.authorOkubo, K-
dc.contributor.authorHonda, T-
dc.contributor.authorHosgood, DH-
dc.contributor.authorKunitoh, H-
dc.contributor.authorPatel, H-
dc.contributor.authorWatanabe, S-
dc.contributor.authorMiyagi, Y-
dc.contributor.authorNakayama, H-
dc.contributor.authorMatsumoto, S-
dc.contributor.authorHorinouchi, H-
dc.contributor.authorTsuboi, M-
dc.contributor.authorHamamoto, R-
dc.contributor.authorWang, JW-
dc.contributor.authoret al-
dc.date.accessioned2023-09-21T06:56:39Z-
dc.date.available2023-09-21T06:56:39Z-
dc.date.issued2023-05-26-
dc.identifier.citationNature Communications, 2023, v. 14, n. 1-
dc.identifier.issn2041-1723-
dc.identifier.urihttp://hdl.handle.net/10722/331528-
dc.description.abstract<p>Lung adenocarcinoma is the most common type of lung cancer. Known risk variants explain only a small fraction of lung adenocarcinoma heritability. Here, we conducted a two-stage genome-wide association study of lung adenocarcinoma of East Asian ancestry (21,658 cases and 150,676 controls; 54.5% never-smokers) and identified 12 novel susceptibility variants, bringing the total number to 28 at 25 independent loci. Transcriptome-wide association analyses together with colocalization studies using a Taiwanese lung expression quantitative trait loci dataset (n=115) identified novel candidate genes, including FADS1 at 11q12 and ELF5 at 11p13. In a multi-ancestry meta-analysis of East Asian and European studies, four loci were identified at 2p11, 4q32, 16q23, and 18q12. At the same time, most of our findings in East Asian populations showed no evidence of association in European populations. In our studies drawn from East Asian populations, a polygenic risk score based on the 25 loci had a stronger association in never-smokers vs. individuals with a history of smoking (P-interaction=0.0058). These findings provide new insights into the etiology of lung adenocarcinoma in individuals from East Asian populations, which could be important in developing translational applications.<br></p>-
dc.languageeng-
dc.publisherNature Research-
dc.relation.ispartofNature Communications-
dc.rightsThis work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.-
dc.titleGenome-wide association study of lung adenocarcinoma in East Asia and comparison with a European population-
dc.typeArticle-
dc.identifier.doi10.1038/s41467-023-38196-z-
dc.identifier.scopuseid_2-s2.0-85160220141-
dc.identifier.volume14-
dc.identifier.issue1-
dc.identifier.eissn2041-1723-
dc.identifier.isiWOS:001008971800001-
dc.identifier.issnl2041-1723-

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