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Article: Natural history of infants with vitamin D deficiency in Hong Kong

TitleNatural history of infants with vitamin D deficiency in Hong Kong
Authors
Keywordsinfants
rickets
serum 25-hydroxyvitamin D
vitamin D
Issue Date30-Dec-2023
PublisherWiley: No OnlineOpen
Citation
Asia Pacific Journal of Clinical Nutrition, 2023, v. 32, n. 4, p. 401-407 How to Cite?
Abstract

Background and Objectives: The usual recommended intake of vitamin D for healthy infants is 400 international unit (IU) daily. However, a high dose of vitamin D at 2000-3000 IU daily is needed for those with vitamin D deficiency (VDD). This study aimed to assess the natural history of a group of healthy infants with VDD and the associated factors for persistent VDD.

Methods and Study Design: Healthy infants detected to have VDD (25OHD <25 nmol/L) in a population study were followed, and their demographics and clinical data were collected.

Results: One hundred and thirty-one subjects (boys = 66%) were included. Their first serum 25OHD was taken at a median age of 87.5 days. None were treated with high-dose vitamin D supplements, but some have been given vitamin D at 400 IU daily. They were assessed again at the median age of 252.5 days when 15 remained to have VDD and 26 were in the insufficient range (25 - 49.9nmol/L). All persistent VDD children were on exclusive breastfeeding. Exclusive breastfeeding and no vitamin D supplementation were significant risk factors for persistent vitamin D insufficiency (<50nmol/L).

Conclusions: Persistent VDD is common among infants exclusively breastfeeding and those who did not receive vitamin D supplementation.


Persistent Identifierhttp://hdl.handle.net/10722/339652
ISSN
2023 Impact Factor: 1.3
2023 SCImago Journal Rankings: 0.408
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorTung, JY-
dc.contributor.authorSo, HK-
dc.contributor.authorTung, KT-
dc.contributor.authorWong, RS-
dc.contributor.authorTsang, HW-
dc.contributor.authorChan, B-
dc.contributor.authorTso, WW-
dc.contributor.authorWong, IC-
dc.contributor.authorYam, JC-
dc.contributor.authorLee, SL-
dc.contributor.authorPang, G-
dc.contributor.authorWong, WH-
dc.contributor.authorCheung, KW-
dc.contributor.authorLeung, WC-
dc.contributor.authorIp, P-
dc.date.accessioned2024-03-11T10:38:17Z-
dc.date.available2024-03-11T10:38:17Z-
dc.date.issued2023-12-30-
dc.identifier.citationAsia Pacific Journal of Clinical Nutrition, 2023, v. 32, n. 4, p. 401-407-
dc.identifier.issn0964-7058-
dc.identifier.urihttp://hdl.handle.net/10722/339652-
dc.description.abstract<p>Background and Objectives: The usual recommended intake of vitamin D for healthy infants is 400 international unit (IU) daily. However, a high dose of vitamin D at 2000-3000 IU daily is needed for those with vitamin D deficiency (VDD). This study aimed to assess the natural history of a group of healthy infants with VDD and the associated factors for persistent VDD.</p><p>Methods and Study Design: Healthy infants detected to have VDD (25OHD <25 nmol/L) in a population study were followed, and their demographics and clinical data were collected.</p><p>Results: One hundred and thirty-one subjects (boys = 66%) were included. Their first serum 25OHD was taken at a median age of 87.5 days. None were treated with high-dose vitamin D supplements, but some have been given vitamin D at 400 IU daily. They were assessed again at the median age of 252.5 days when 15 remained to have VDD and 26 were in the insufficient range (25 - 49.9nmol/L). All persistent VDD children were on exclusive breastfeeding. Exclusive breastfeeding and no vitamin D supplementation were significant risk factors for persistent vitamin D insufficiency (<50nmol/L).</p><p>Conclusions: Persistent VDD is common among infants exclusively breastfeeding and those who did not receive vitamin D supplementation.<br></p>-
dc.languageeng-
dc.publisherWiley: No OnlineOpen-
dc.relation.ispartofAsia Pacific Journal of Clinical Nutrition-
dc.rightsThis work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.-
dc.subjectinfants-
dc.subjectrickets-
dc.subjectserum 25-hydroxyvitamin D-
dc.subjectvitamin D-
dc.titleNatural history of infants with vitamin D deficiency in Hong Kong-
dc.typeArticle-
dc.identifier.doi10.6133/apjcn.202312_32(4).0004-
dc.identifier.scopuseid_2-s2.0-85180808335-
dc.identifier.volume32-
dc.identifier.issue4-
dc.identifier.spage401-
dc.identifier.epage407-
dc.identifier.eissn1440-6047-
dc.identifier.isiWOS:001146536100007-
dc.identifier.issnl0964-7058-

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