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Article: A two-sample Mendelian randomization study explores metabolic profiling of different glycemic traits

TitleA two-sample Mendelian randomization study explores metabolic profiling of different glycemic traits
Authors
Issue Date8-Mar-2024
PublisherNature Research
Citation
Communications Biology, 2024, v. 7, n. 1 How to Cite?
Abstract

We assessed the causal relation of four glycemic traits and type 2 diabetes liability with 167 metabolites using Mendelian randomization with various sensitivity analyses and a reverse Mendelian randomization analysis. We extracted instruments for fasting glucose, 2-h glucose, fasting insulin, and glycated hemoglobin from the Meta-Analyses of Glucose and Insulin-related traits Consortium (n = 200,622), and those for type 2 diabetes liability from a meta-analysis of multiple cohorts (148,726 cases, 965,732 controls) in Europeans. Outcome data were from summary statistics of 167 metabolites from the UK Biobank (n = 115,078). Fasting glucose and 2-h glucose were not associated with any metabolite. Higher glycated hemoglobin was associated with higher free cholesterol in small low-density lipoprotein. Type 2 diabetes liability and fasting insulin were inversely associated with apolipoprotein A1, total cholines, lipoprotein subfractions in high-density-lipoprotein and intermediate-density lipoproteins, and positively associated with aromatic amino acids. These findings indicate hyperglycemia-independent patterns and highlight the role of insulin in type 2 diabetes development. Further studies should evaluate these glycemic traits in type 2 diabetes diagnosis and clinical management.


Persistent Identifierhttp://hdl.handle.net/10722/342050
ISSN
2023 Impact Factor: 5.2
2023 SCImago Journal Rankings: 2.090
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorWong, Tommy H T-
dc.contributor.authorMo, Jacky M Y-
dc.contributor.authorZhou, Mingqi-
dc.contributor.authorZhao, Jie V-
dc.contributor.authorSchooling, C Mary-
dc.contributor.authorHe, Baoting-
dc.contributor.authorLuo, Shan-
dc.contributor.authorAu Yeung, Shiu Lun-
dc.date.accessioned2024-03-26T05:39:19Z-
dc.date.available2024-03-26T05:39:19Z-
dc.date.issued2024-03-08-
dc.identifier.citationCommunications Biology, 2024, v. 7, n. 1-
dc.identifier.issn2399-3642-
dc.identifier.urihttp://hdl.handle.net/10722/342050-
dc.description.abstract<p>We assessed the causal relation of four glycemic traits and type 2 diabetes liability with 167 metabolites using Mendelian randomization with various sensitivity analyses and a reverse Mendelian randomization analysis. We extracted instruments for fasting glucose, 2-h glucose, fasting insulin, and glycated hemoglobin from the Meta-Analyses of Glucose and Insulin-related traits Consortium (<em>n</em> = 200,622), and those for type 2 diabetes liability from a meta-analysis of multiple cohorts (148,726 cases, 965,732 controls) in Europeans. Outcome data were from summary statistics of 167 metabolites from the UK Biobank (<em>n</em> = 115,078). Fasting glucose and 2-h glucose were not associated with any metabolite. Higher glycated hemoglobin was associated with higher free cholesterol in small low-density lipoprotein. Type 2 diabetes liability and fasting insulin were inversely associated with apolipoprotein A1, total cholines, lipoprotein subfractions in high-density-lipoprotein and intermediate-density lipoproteins, and positively associated with aromatic amino acids. These findings indicate hyperglycemia-independent patterns and highlight the role of insulin in type 2 diabetes development. Further studies should evaluate these glycemic traits in type 2 diabetes diagnosis and clinical management.</p>-
dc.languageeng-
dc.publisherNature Research-
dc.relation.ispartofCommunications Biology-
dc.rightsThis work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.-
dc.titleA two-sample Mendelian randomization study explores metabolic profiling of different glycemic traits-
dc.typeArticle-
dc.identifier.doi10.1038/s42003-024-05977-1-
dc.identifier.scopuseid_2-s2.0-85187111151-
dc.identifier.volume7-
dc.identifier.issue1-
dc.identifier.eissn2399-3642-
dc.identifier.isiWOS:001181434100007-
dc.identifier.issnl2399-3642-

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