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Article: 3D-printed PNAGA thermosensitive hydrogelbased microrobots: An effective cancer therapy by temperature-triggered drug release
Title | 3D-printed PNAGA thermosensitive hydrogelbased microrobots: An effective cancer therapy by temperature-triggered drug release |
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Authors | |
Keywords | 3D printing Drug release Magnetic microrobot PNAGA thermosensitive hydrogel Swelling |
Issue Date | 15-Mar-2023 |
Publisher | AccScience Publishing |
Citation | International Journal of Bioprinting, 2023, v. 9, n. 3, p. 272-283 How to Cite? |
Abstract | Hydrogels with temperature-responsive capabilities are increasingly utilized and researched owing to their prospective applications in the biomedical field. In this work, we developed thermosensitive poly-N-acryloyl glycinamide (PNAGA) hydrogels-based microrobots by using the advanced two-photon polymerization printing technology. N-acryloyl glycinamide (NAGA) concentration-dependent thermosensitive performance was presented and the underlying mechanism behind was discussed. Fast swelling behavior was achieved by PNAGA-100 at 45°C with a growth rate of 22.5%, which is the highest value among these PNAGA hydrogels. In addition, a drug release test of PNAGA-100-based thermosensitive hydrogels was conducted. Our microrobots demonstrate higher drug release amount at 45°C (close to body temperature) than at 25°C, indicating their great potential to be utilized in drug delivery in the human body. Furthermore, PNAGA-100-based thermosensitive microrobots are able to swim along the route as designed under the magnetic actuator after incubating with Fe@ZIF-8 crystals. Our biocompatible thermosensitive magnetic microrobots open up new options for biomedical applications and our work provides a robust pathway to the development of high-performance thermosensitive hydrogel-based microrobots. |
Persistent Identifier | http://hdl.handle.net/10722/345518 |
ISSN | 2023 Impact Factor: 6.8 2023 SCImago Journal Rankings: 0.724 |
DC Field | Value | Language |
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dc.contributor.author | Zhou, Yan | - |
dc.contributor.author | Ye, Min | - |
dc.contributor.author | Zhao, Hongyu | - |
dc.contributor.author | Wang, Xiaopu | - |
dc.date.accessioned | 2024-08-27T09:09:19Z | - |
dc.date.available | 2024-08-27T09:09:19Z | - |
dc.date.issued | 2023-03-15 | - |
dc.identifier.citation | International Journal of Bioprinting, 2023, v. 9, n. 3, p. 272-283 | - |
dc.identifier.issn | 2424-7723 | - |
dc.identifier.uri | http://hdl.handle.net/10722/345518 | - |
dc.description.abstract | Hydrogels with temperature-responsive capabilities are increasingly utilized and researched owing to their prospective applications in the biomedical field. In this work, we developed thermosensitive poly-N-acryloyl glycinamide (PNAGA) hydrogels-based microrobots by using the advanced two-photon polymerization printing technology. N-acryloyl glycinamide (NAGA) concentration-dependent thermosensitive performance was presented and the underlying mechanism behind was discussed. Fast swelling behavior was achieved by PNAGA-100 at 45°C with a growth rate of 22.5%, which is the highest value among these PNAGA hydrogels. In addition, a drug release test of PNAGA-100-based thermosensitive hydrogels was conducted. Our microrobots demonstrate higher drug release amount at 45°C (close to body temperature) than at 25°C, indicating their great potential to be utilized in drug delivery in the human body. Furthermore, PNAGA-100-based thermosensitive microrobots are able to swim along the route as designed under the magnetic actuator after incubating with Fe@ZIF-8 crystals. Our biocompatible thermosensitive magnetic microrobots open up new options for biomedical applications and our work provides a robust pathway to the development of high-performance thermosensitive hydrogel-based microrobots. | - |
dc.language | eng | - |
dc.publisher | AccScience Publishing | - |
dc.relation.ispartof | International Journal of Bioprinting | - |
dc.rights | This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License. | - |
dc.subject | 3D printing | - |
dc.subject | Drug release | - |
dc.subject | Magnetic microrobot | - |
dc.subject | PNAGA thermosensitive hydrogel | - |
dc.subject | Swelling | - |
dc.title | 3D-printed PNAGA thermosensitive hydrogelbased microrobots: An effective cancer therapy by temperature-triggered drug release | - |
dc.type | Article | - |
dc.description.nature | published_or_final_version | - |
dc.identifier.doi | 10.18063/ijb.709 | - |
dc.identifier.scopus | eid_2-s2.0-85150875079 | - |
dc.identifier.volume | 9 | - |
dc.identifier.issue | 3 | - |
dc.identifier.spage | 272 | - |
dc.identifier.epage | 283 | - |
dc.identifier.eissn | 2424-8002 | - |
dc.identifier.issnl | 2424-8002 | - |